公开(公告)号：US08785651B2

公开(公告)日：2014-07-22

申请号：US13142536

申请日：2009-03-24

申请人： Takashi Miki ,  Yasuharu Shimasaki ,  Srinivasan Babu ,  Zhigang Cheng ,  Mark E. Reynolds ,  Qingping Tian

发明人： Takashi Miki ,  Yasuharu Shimasaki ,  Srinivasan Babu ,  Zhigang Cheng ,  Mark E. Reynolds ,  Qingping Tian

IPC分类号： C07F5/04 ,  C07F5/02

CPC分类号： C07F5/025

摘要： The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.

摘要翻译： 硼酸酯化合物的制造方法技术领域本发明涉及硼酸酯化合物的制造方法，其特征在于，在含氮有机碱，镍催化剂，膦化合物和溶剂的存在下，使芳基卤化合物与二硼酸酯化合物反应。 根据本发明的制造方法，即使使用镍催化剂作为催化剂，也能以足够高的收率获得所需的硼酸酯化合物。 此外，即使使用价格低廉，反应性低的芳基氯或芳基溴作为芳基卤化合物，可以以足够高的收率得到所需的硼酸酯化合物。

公开(公告)号：US20120123122A1

公开(公告)日：2012-05-17

申请号：US13142536

申请日：2009-03-24

申请人： Takashi Miki ,  Yasuharu Shimasaki ,  Srinivasan Babu ,  Zhigang Cheng ,  Mark E. Reynolds ,  Qingping Tian

发明人： Takashi Miki ,  Yasuharu Shimasaki ,  Srinivasan Babu ,  Zhigang Cheng ,  Mark E. Reynolds ,  Qingping Tian

IPC分类号： C07F5/04

CPC分类号： C07F5/025

摘要： The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.

摘要翻译： 硼酸酯化合物的制造方法技术领域本发明涉及硼酸酯化合物的制造方法，其特征在于，在含氮有机碱，镍催化剂，膦化合物和溶剂的存在下，使芳基卤化合物与二硼酸酯化合物反应。 根据本发明的制造方法，即使使用镍催化剂作为催化剂，也能以足够高的收率获得所需的硼酸酯化合物。 此外，即使使用价格低廉，反应性低的芳基氯或芳基溴作为芳基卤化合物，可以以足够高的收率得到所需的硼酸酯化合物。