公开(公告)号：US20110091915A1

公开(公告)日：2011-04-21

申请号：US12995489

申请日：2009-05-29

申请人： Takashi Obara ,  Sadaaki Mizoguchi

发明人： Takashi Obara ,  Sadaaki Mizoguchi

IPC分类号： G01N33/53

CPC分类号： G01N33/6854 ,  G01N33/6893 ,  G01N2800/347

摘要： There is provided a renal disease testing method comprising a complex detection step of detecting a complex of human uromodulin and human IgA in a sample derived from urine collected from a subject. It is preferred that the renal disease testing method of the invention further comprises a determination step of assessing the whether the renal disease is IgA nephropathy based on the ratio of the amount of the complex detected in the complex detection step to the amount of urinary proteins in the sample. The renal disease testing method of the invention has good detection sensitivity and specificity, and can conveniently and safely assess the existence of a renal disease (preferably, IgA nephropathy).

摘要翻译： 提供了一种肾脏疾病测试方法，其包括在从受试者收集的尿中得到的样品中检测人尿调制蛋白和人IgA的复合物的复合物检测步骤。 优选本发明的肾脏疾病检测方法还包括以下步骤：基于复合物检测步骤检测到的复合物的量与尿蛋白质量的比例来评估肾脏疾病是否为IgA肾病的判定步骤 例子。 本发明的肾病检测方法具有良好的检测灵敏度和特异性，可以方便，安全地评估肾病（优选IgA肾病）的存在。

公开(公告)号：US08426142B2

公开(公告)日：2013-04-23

申请号：US12995489

申请日：2009-05-29

申请人： Takashi Obara ,  Sadaaki Mizoguchi

发明人： Takashi Obara ,  Sadaaki Mizoguchi

IPC分类号： G01N33/53

CPC分类号： G01N33/6854 ,  G01N33/6893 ,  G01N2800/347

摘要： There is provided a renal disease testing method comprising a complex detection step of detecting a complex of human uromodulin and human IgA in a sample derived from urine collected from a subject. It is preferred that the renal disease testing method of the invention further comprises a determination step of assessing the whether the renal disease is IgA nephropathy based on the ratio of the amount of the complex detected in the complex detection step to the amount of urinary proteins in the sample. The renal disease testing method of the invention has good detection sensitivity and specificity, and can conveniently and safely assess the existence of a renal disease (preferably, IgA nephropathy).

摘要翻译： 提供了一种肾脏疾病测试方法，其包括在从受试者收集的尿中得到的样品中检测人尿调制蛋白和人IgA的复合物的复合物检测步骤。 优选本发明的肾脏疾病检测方法还包括以下步骤：基于复合物检测步骤检测到的复合物的量与尿蛋白质量的比例来评估肾脏疾病是否为IgA肾病的判定步骤 例子。 本发明的肾病检测方法具有良好的检测灵敏度和特异性，可以方便，安全地评估肾病（优选IgA肾病）的存在。

公开(公告)号：US20110143382A1

公开(公告)日：2011-06-16

申请号：US12995507

申请日：2009-05-29

申请人： Takashi Obara ,  Sadaaki Mizoguchi ,  Osamu Hotta

发明人： Takashi Obara ,  Sadaaki Mizoguchi ,  Osamu Hotta

IPC分类号： G01N33/53

CPC分类号： G01N33/6854 ,  G01N2800/347

摘要： There is provided a renal disease testing method comprising a complex detection step of detecting a complex of an antigen derived from human renal mesangial cells and human IgA in a sample derived from urine collected from a subject. It is preferred that the renal disease testing method of the invention further comprises a determination step of assessing the whether the renal disease is IgA nephropathy based on the ratio of the amount of the complex detected in the complex detection step to the amount of urinary proteins in the sample. The renal disease testing method of the invention has good detection sensitivity and specificity, and can conveniently and safely assess the existence of a renal disease (preferably, IgA nephropathy).

摘要翻译： 提供了一种肾病检测方法，其包括检测来自受试者收集的尿液的样品中衍生自人肾小球系膜细胞和人IgA的抗原的复合物检测步骤。 优选本发明的肾脏疾病检测方法还包括以下步骤：基于复合物检测步骤检测到的复合物的量与尿蛋白质量的比例来评估肾脏疾病是否为IgA肾病的判定步骤 例子。 本发明的肾病检测方法具有良好的检测灵敏度和特异性，可以方便，安全地评估肾病（优选IgA肾病）的存在。