公开(公告)号：US06753403B2

公开(公告)日：2004-06-22

申请号：US10082239

申请日：2002-02-26

申请人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

发明人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

IPC分类号： C08G6400

CPC分类号： B01F7/00583 ,  B01F7/04 ,  B01F7/042 ,  B01F7/043 ,  B01F2215/0427 ,  B01F2215/0481 ,  B01F2215/0495 ,  C08G64/205 ,  C08G64/307

摘要： A process for producing polycarbonate designed to improve the quality of polycarbonate as a polymerization product polymer and reduce the investment and operating costs is provided. Polycarbonate is produced in two horizontal cylindrical agitation reactors provided with agitation blades successively extended through the vessel and partly with agitation blades having a screw function, as horizontally ganged together in series without any agitator center shaft, where the primary agitation reactor is a uniaxial horizontal agitation reactor with the agitation blades rotating at a low speed ranging from 1 rpm to 10 rpm, while keeping a clearance between the inner wall of the vessel ad the agitation blades in a range of 1 mm to 50 mm, and the secondary agitation reactor is a biaxial horizontal agitation reactor with agitation blades provided horizontally and in parallel, without any rotating center shaft, which conducts treatment by agitation at a low speed ranging from 1 rpm to 15 rpm.

摘要翻译： 提供了一种生产聚碳酸酯的方法，其设计用于提高作为聚合产物聚合物的聚碳酸酯的质量并降低投资和操作成本。 聚碳酸酯在两个水平的圆柱形搅拌反应器中制备，该反应器具有连续延伸穿过容器的搅拌叶片，部分地具有螺旋功能的搅拌叶片，其水平组合在一起，没有任何搅拌器中心轴，其中初级搅拌反应器是单轴卧式搅拌 反应器，搅拌叶片以1rpm至10rpm的低速旋转，同时将容器内壁与搅拌叶片之间的间隙保持在1mm至50mm的范围内，二次搅拌反应器为 具有搅拌叶片的双轴卧式搅拌反应器，水平并平行设置，没有任何旋转的中心轴，其通过以1rpm至15rpm的低速搅拌进行处理。

公开(公告)号：US06350848B1

公开(公告)日：2002-02-26

申请号：US09940884

申请日：2001-08-29

申请人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

发明人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

IPC分类号： C08G6400

CPC分类号： B01F7/00583 ,  B01F7/04 ,  B01F7/042 ,  B01F7/043 ,  B01F2215/0427 ,  B01F2215/0481 ,  B01F2215/0495 ,  C08G64/205 ,  C08G64/307

摘要： A process for producing polycarbonate designed to improve the quality of polycarbonate as a polymerization product polymer and reduce the investment and operating costs is provided. Polycarbonate is produced in two horizontal cylindrical agitation reactors provided with agitation blades successively extended through the vessel and partly with agitation blades having a screw function, as horizontally ganged together in series without any agitator center shaft, where the primary agitation reactor is a uniaxial horizontal agitation reactor with the agitation blades rotating at a low speed ranging from 1 rpm to 10 rpm, while keeping a clearance between the inner wall of the vessel ad the agitation blades in a range of 1 mm to 50 mm, and the secondary agitation reactor is a biaxial horizontal agitation reactor with agitation blades provided horizontally and in parallel, without any rotating center shaft, which conducts treatment by agitation at a low speed ranging from 1 rpm to 15 rpm.

摘要翻译： 提供了一种生产聚碳酸酯的方法，其设计用于提高作为聚合产物聚合物的聚碳酸酯的质量并降低投资和操作成本。 聚碳酸酯在两个水平的圆柱形搅拌反应器中制备，该反应器具有连续延伸穿过容器的搅拌叶片，部分地具有螺旋功能的搅拌叶片，其水平组合在一起，没有任何搅拌器中心轴，其中初级搅拌反应器是单轴卧式搅拌 反应器，搅拌叶片以1rpm至10rpm的低速旋转，同时将容器内壁与搅拌叶片之间的间隙保持在1mm至50mm的范围内，二次搅拌反应器为 具有搅拌叶片的双轴卧式搅拌反应器，水平并平行设置，没有任何旋转的中心轴，其通过以1rpm至15rpm的低速搅拌进行处理。

公开(公告)号：US06329495B2

公开(公告)日：2001-12-11

申请号：US09790514

申请日：2001-02-23

申请人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

发明人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

IPC分类号： C08G6400

CPC分类号： B01F7/00583 ,  B01F7/04 ,  B01F7/042 ,  B01F7/043 ,  B01F2215/0427 ,  B01F2215/0481 ,  B01F2215/0495 ,  C08G64/205 ,  C08G64/307

摘要： A process for producing polycarbonate designed to improve the quality of polycarbonate as a polymerization product polymer and reduce the investment and operating costs is provided. Polycarbonate is produced in two horizontal cylindrical agitation reactors provided with agitation blades successively extended through the vessel and partly with agitation blades having a screw function, as horizontally ganged together in series without any agitator center shaft, where the primary agitation reactor is a uniaxial horizontal agitation reactor with the agitation blades rotating at a low speed ranging from 1 rpm to 10 rpm, while keeping a clearance between the inner wall of the vessel ad the agitation blades in a range of 1 mm to 50 mm, and the secondary agitation reactor is a biaxial horizontal agitation reactor with agitation blades provided horizontally and in parallel, without any rotating center shaft, which conducts treatment by agitation at a low speed ranging from 1 rpm to 15 rpm.

摘要翻译： 提供了一种生产聚碳酸酯的方法，其设计用于提高作为聚合产物聚合物的聚碳酸酯的质量并降低投资和操作成本。 聚碳酸酯在两个水平的圆柱形搅拌反应器中制备，该反应器具有连续延伸通过容器的搅拌叶片，部分地具有螺旋功能的搅拌叶片，其水平组合在一起，没有任何搅拌器中心轴，其中初级搅拌反应器是单轴卧式搅拌 反应器，搅拌叶片以1rpm至10rpm的低速旋转，同时将容器内壁与搅拌叶片之间的间隙保持在1mm至50mm的范围内，二次搅拌反应器为 具有搅拌叶片的双轴卧式搅拌反应器，水平并平行设置，没有任何旋转的中心轴，其通过以1rpm至15rpm的低速搅拌进行处理。

公开(公告)号：US06265525B1

公开(公告)日：2001-07-24

申请号：US09486913

申请日：2000-10-12

申请人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

发明人： Takatoshi Kinoshita ,  Kazunori Harada ,  Seiji Motohiro

IPC分类号： C08G6400

CPC分类号： B01F7/00583 ,  B01F7/04 ,  B01F7/042 ,  B01F7/043 ,  B01F2215/0427 ,  B01F2215/0481 ,  B01F2215/0495 ,  C08G64/205 ,  C08G64/307

摘要： A process for producing polycarbonate designed to improve the quality of polycarbonate as a polymerization product polymer and reduce the investment and operating costs is provided. Polycarbonate is produced in two horizontal cylindrical agitation reactors provided with agitation blades successively extended through the vessel and partly with agitation blades having a screw function, as horizontally ganged together in series without any agitator center shaft, where the primary agitation reactor is a uniaxial horizontal agitation reactor with the agitation blades rotating at a low speed ranging from 1 rpm to 10 rpm, while keeping a clearance between the inner wall of the vessel ad the agitation blades in a range of 1 mm to 50 mm, and the secondary agitation reactor is a biaxial horizontal agitation reactor with agitation blades provided horizontally and in parallel, without any rotating center shaft, which conducts treatment by agitation at a low speed ranging from 1 rpm to 15 rpm.

摘要翻译： 提供了一种生产聚碳酸酯的方法，其设计用于提高作为聚合产物聚合物的聚碳酸酯的质量并降低投资和操作成本。 聚碳酸酯在两个水平的圆柱形搅拌反应器中制备，该反应器具有连续延伸穿过容器的搅拌叶片，部分地具有螺旋功能的搅拌叶片，其水平组合在一起，没有任何搅拌器中心轴，其中初级搅拌反应器是单轴卧式搅拌 反应器，搅拌叶片以1rpm至10rpm的低速旋转，同时将容器内壁与搅拌叶片之间的间隙保持在1mm至50mm的范围内，二次搅拌反应器为 具有搅拌叶片的双轴卧式搅拌反应器，水平并平行设置，没有任何旋转的中心轴，其通过以1rpm至15rpm的低速搅拌进行处理。

公开(公告)号：US08609389B2

公开(公告)日：2013-12-17

申请号：US13257066

申请日：2010-03-19

申请人： Kazunori Harada ,  Hiroyuki Kobayashi ,  Taro Suga ,  Hiroyuki Yamaguchi ,  Akira Tsunoda ,  Shigeaki Kato

发明人： Kazunori Harada ,  Hiroyuki Kobayashi ,  Taro Suga ,  Hiroyuki Yamaguchi ,  Akira Tsunoda ,  Shigeaki Kato

IPC分类号： C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12N9/58

摘要： The present invention provides an improved type protease which comprises an amino acid sequence that is at least 75% identical to SEQ ID NO:3, said improved type protease has at least one mutation selected from the group consisting of: (A) replacement of glutamine corresponding to glutamine at position 265 in SEQ ID NO: 3 with an acidic amino acid; and (B) replacement of glutamine at position 266 in SEQ ID NO: 3 with an acidic amino acid, and wherein said improved type protease has milk-clotting activity.

摘要翻译： 本发明提供一种改良型蛋白酶，其包含与SEQ ID NO：3至少75％相同的氨基酸序列，所述改良型蛋白酶具有至少一种选自以下的突变：（A）谷氨酰胺的替换 对应于具有酸性氨基酸的SEQ ID NO：3中265位的谷氨酰胺; 和（B）用酸性氨基酸置换SEQ ID NO：3中266位的谷氨酰胺，其中所述改良型蛋白酶具有乳凝活性。

公开(公告)号：US5747493A

公开(公告)日：1998-05-05

申请号：US557167

申请日：1995-12-21

申请人： Takayuki Namiki ,  Toshihiro Morimoto ,  Kenichi Kishii ,  Nobuyuki Kawakatsu ,  Makoto Kimura ,  Kyoko Yamasaki ,  Mariko Onoda ,  Yuji Yoshiko ,  Kazunori Harada ,  Masayuki Yanagi ,  Takeshi Yamamoto ,  Masato Inazu ,  Masaki Mitani

发明人： Takayuki Namiki ,  Toshihiro Morimoto ,  Kenichi Kishii ,  Nobuyuki Kawakatsu ,  Makoto Kimura ,  Kyoko Yamasaki ,  Mariko Onoda ,  Yuji Yoshiko ,  Kazunori Harada ,  Masayuki Yanagi ,  Takeshi Yamamoto ,  Masato Inazu ,  Masaki Mitani

IPC分类号： A61K31/495 ,  C07D213/74 ,  C07D295/13

CPC分类号： A61K31/495 ,  C07D213/74 ,  C07D295/13

摘要： A method for inhibiting dopamine re-uptake and treating Parkinson's disease is disclosed comprising administering a compound represented by formula (1) or a physiologically acceptable salt thereof as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 represent each hydrogen or halogen, R.sup.3 represents hydrogen, alkyl or acyl, R.sup.4 represents hydrogen, alkyl, acyl, alkylsulfonyl or optionally esterified carboxyl, Ar represents optionally substituted phenyl or nitrogenous monocyclic heteroaromatic group, m represents a number of 1 to 5, and n represents a number of 0 to 5.

摘要翻译： PCT No.PCT / JP94 / 00728 Sec。 371 1995年12月21日第 102（e）日期1995年12月21日PCT 1994年4月28日PCT PCT。 出版物WO95 / 00149 1995年1月5日公开了一种抑制多巴胺再摄取和治疗帕金森病的方法，包括给予式（1）表示的化合物或其生理学上可接受的盐作为活性成分：其中R1和R2 代表每个氢或卤素，R 3表示氢，烷基或酰基，R 4表示氢，烷基，酰基，烷基磺酰基或任意酯化的羧基，Ar表示任选取代的苯基或含氮单环杂芳基，m表示1至5的数，n表示 代表0到5的数字。

公开(公告)号：US20120040436A1

公开(公告)日：2012-02-16

申请号：US13257066

申请日：2010-03-19

申请人： Kazunori Harada ,  Hiroyuki Kobayashi ,  Taro Suga ,  Hiroyuki Yamaguchi ,  Akira Tsunoda ,  Shigeaki Kato

发明人： Kazunori Harada ,  Hiroyuki Kobayashi ,  Taro Suga ,  Hiroyuki Yamaguchi ,  Akira Tsunoda ,  Shigeaki Kato

IPC分类号： C12N9/50 ,  C12N15/81 ,  C12N1/19 ,  C12N15/57

CPC分类号： C12N9/58

摘要： The present invention provides an improved type protease which comprises an amino acid sequence that is at least 75% identical to SEQ ID NO:3, said improved type protease has at least one mutation selected from the group consisting of: (A) replacement of glutamine corresponding to glutamine at position 265 in SEQ ID NO: 3 with an acidic amino acid; and (B) replacement of glutamine at position 266 in SEQ ID NO: 3 with an acidic amino acid, and wherein said improved type protease has milk-clotting activity.

摘要翻译： 本发明提供一种改良型蛋白酶，其包含与SEQ ID NO：3至少75％相同的氨基酸序列，所述改良型蛋白酶具有至少一种选自以下的突变：（A）谷氨酰胺的替换 对应于具有酸性氨基酸的SEQ ID NO：3中265位的谷氨酰胺; 和（B）用酸性氨基酸置换SEQ ID NO：3中266位的谷氨酰胺，其中所述改良型蛋白酶具有乳凝活性。

公开(公告)号：US5391552A

公开(公告)日：1995-02-21

申请号：US988911

申请日：1993-05-10

申请人： Masato Inazu ,  Yoshiyuki Miyata ,  Toshihiro Morimoto ,  Takeshi Yamamoto ,  Yuji Yoshiko ,  Kazunori Harada ,  Yoshiharu Momota ,  Masayuki Yanagi ,  Ryoko Yokota ,  Tetsuo Katoh ,  Takayuki Namiki ,  Makoto Kimura ,  Nobuyuki Kawakatsu

发明人： Masato Inazu ,  Yoshiyuki Miyata ,  Toshihiro Morimoto ,  Takeshi Yamamoto ,  Yuji Yoshiko ,  Kazunori Harada ,  Yoshiharu Momota ,  Masayuki Yanagi ,  Ryoko Yokota ,  Tetsuo Katoh ,  Takayuki Namiki ,  Makoto Kimura ,  Nobuyuki Kawakatsu

IPC分类号： C07D295/088 ,  C07D295/092 ,  C07D295/13 ,  A61K31/495

CPC分类号： C07D295/088 ,  C07D295/13

摘要： A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R.sup.3 represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR.sup.4 - wherein R.sup.4 represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.

摘要翻译： PCT No.PCT / JP91 / 01227 Sec。 371日期：1993年5月10日 102（e）日期1993年5月10日PCT 1991年9月13日PCT PCT。 出版物WO92 / 05165 1992年4月2日，由通式（1）表示的二苯基哌嗪衍生物及其盐，以及含有与活性成分相同的循环器官的药物：其中，R1和R2可以相同 或各自表示氢，卤素，烷基，烷氧基，硝基，氨基，羟基，任意酯化的羧基或三氟甲基; R3表示氢，烷基，芳烷基，酰基，硝基或任意酯化的羧甲基; 卤素，烷基，烷氧基，芳氧基，芳烷氧基，硝基，氨基，氰基，酰基，羟基，任意酯化的羧基，取代的磺酰基，芳基或三氟甲基的苯基或萘基。 Z表示硫或-NR4-，其中R4表示氢，烷基，芳烷基，酰基，芳基，取代的磺酰基或任选酯化的羧基; m表示1〜5的数; n表示0〜5的数。