公开(公告)号：US07312239B2

公开(公告)日：2007-12-25

申请号：US10643404

申请日：2003-08-18

申请人： Takayuki Tanaka ,  Tatsuhiko Mori

发明人： Takayuki Tanaka ,  Tatsuhiko Mori

IPC分类号： A61K31/4152 ,  A61K31/381 ,  A61K31/341

CPC分类号： A61K31/4152

摘要： An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided a method for prevention and/or therapy of arterial wall injury which comprises a step of administering the pyrazolone derivative represented by the following formula (I) or the physiologically acceptable salt thereof, or the hydrate or solvate thereof in a preventively or therapeutically effective amount to mammals including humans: wherein R1 represents a hydrogen atom, an aryl group, an alkyl group, or an alkoxycarbonylalkyl group; R2 represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group or a hydroxyalkyl group; or R1 and R2 are combined with each other to represent an alkylene group; and R3 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, a benzyl group, a naphthyl group, a phenyl group, or a phenyl group substituted with 1 to 3 substituents selected from the group consisting of an alkyl group, an alkoxy group, a hydroxyalkyl group, an alkoxycarbonyl group, an alkylmercapto group, an alkylamino group, a dialkylamino group, a halogen atom, a trifluoromethyl group, a carboxyl group, a cyano group, a hydroxyl group, a nitro group, an amino group and an acetamide group.

摘要翻译： 本发明的目的是提供一种可用于预防和/或治疗动脉壁损伤的药物和方法。 根据本发明，提供了一种预防和/或治疗动脉壁损伤的方法，包括给予由下式（I）表示的吡唑啉酮衍生物或其生理学上可接受的盐，或其水合物或溶剂化物 其具有预防或治疗有效量的哺乳动物包括人：其中R 1表示氢原子，芳基，烷基或烷氧基羰基烷基; R 2表示氢原子，芳氧基，芳基巯基，烷基或羟烷基; 或R 1和R 2彼此结合以表示亚烷基; R 3表示氢原子，烷基，环烷基，羟基烷基，苄基，萘基，苯基或被1〜3个取代基取代的苯基 由烷基，烷氧基，羟基烷基，烷氧基羰基，烷基巯基，烷基氨基，二烷基氨基，卤素原子，三氟甲基，羧基，氰基， 羟基，硝基，氨基和乙酰胺基。

公开(公告)号：US20110124181A1

公开(公告)日：2011-05-26

申请号：US12948268

申请日：2010-11-17

申请人： Tamaki Suzuki ,  Tatsuhiko Mori

发明人： Tamaki Suzuki ,  Tatsuhiko Mori

IPC分类号： H01L21/78

CPC分类号： B28D5/0011 ,  B28D5/0076 ,  B28D5/022

摘要： A cutting method for cutting a workpiece by using a cutting blade. The cutting method includes the steps of attaching an adhesive sheet to one surface of the workpiece, holding the workpiece through the adhesive sheet on holding means, and feeding the cutting blade into the workpiece until reaching the adhesive sheet as supplying a cutting fluid having a temperature of 10° C. or less, thereby cutting the workpiece.

摘要翻译： 一种用于通过使用切割刀片切割工件的切割方法。 切割方法包括以下步骤：将粘合片粘附到工件的一个表面上，将工件通过粘合片保持在保持装置上，并将切割刀片进给到工件中，直到到达粘合片，因为提供具有温度 为10℃以下，切断工件。