-
公开(公告)号：US20180263967A1
公开(公告)日：2018-09-20
申请号：US15754934
申请日：2016-08-24
发明人： Akira KAIEDA , Naoki ISHII , Hiroshi NARA , Masato YOSHIKAWA , Masaki DAINI
IPC分类号： A61K31/454 , A61K31/4545 , A61K31/5377 , A61P29/00
CPC分类号： A61K31/454 , A61K31/4545 , A61K31/5377 , A61P29/00 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of inflammatory disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
-
公开(公告)号：US20180118708A1
公开(公告)日：2018-05-03
申请号：US15572231
申请日：2016-05-06
发明人： Toshitake KOBAYASHI , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
CPC分类号： C07D317/72 , A61K31/357 , A61P1/16 , A61P9/10 , A61P25/02 , A61P29/00 , A61P37/00
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of autoimmune disease and/or inflammatory disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like.The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
-
公开(公告)号：US20210024512A1
公开(公告)日：2021-01-28
申请号：US17043162
申请日：2019-03-28
发明人： Yoshinori YOSHIDA , Kenji MIKI , Akira KAIEDA , Shigeru KONDO , Hiroshi NARA , Yoshinori IKEURA
IPC分类号： C07D409/14 , C07D403/04
摘要： The present invention provides a heterocyclic compound having an activity to promote the maturation of a cardiomyocyte.
A compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof has an activity to promote the maturation of a cardiomyocyte, and is useful as a cardiomyocyte maturation promoter.-
公开(公告)号：US20190008836A1
公开(公告)日：2019-01-10
申请号：US15745290
申请日：2016-07-15
发明人： Akira KAIEDA , Masaki DAINI , Hiroshi NARA , Masato YOSHIKAWA , Naoki ISHII , Masashi TOYOFUKU , Kousuke HIDAKA
IPC分类号： A61K31/437 , A61P25/28 , A61K31/4245 , A61K31/4035 , A61K31/4439
CPC分类号： A61K31/437 , A61K31/4035 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/444 , A61P25/28 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
-
公开(公告)号：US20160326102A1
公开(公告)日：2016-11-10
申请号：US15148210
申请日：2016-05-06
发明人： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC分类号： C07C317/12 , C07D309/28 , C07D317/72
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like.The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
摘要翻译： （其中，在说明书中更详细地说明每个符号）。
-
公开(公告)号：US20170066737A1
公开(公告)日：2017-03-09
申请号：US15356906
申请日：2016-11-21
发明人： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC分类号： C07D317/72 , C07C317/46 , C07D309/28 , C07C317/44
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: wherein, each symbol is explained in greater detail in the specification.
摘要翻译： 其中，在说明书中更详细地说明每个符号。
-
公开(公告)号：US20170015655A1
公开(公告)日：2017-01-19
申请号：US15210965
申请日：2016-07-15
发明人： Akira KAIEDA , Masashi TOYOFUKU , Masaki DAINI , Hiroshi NARA , Masato YOSHIKAWA , Naoki ISHII , Kousuke HIDAKA
IPC分类号： C07D413/14 , C07D417/14 , C07D491/08 , C07D491/107 , C07D413/04 , C07D471/04
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D491/08 , C07D491/107 , C07D498/08
摘要： The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 其中每个符号如说明书中所定义，或其盐。
-
公开(公告)号：US20160326133A1
公开(公告)日：2016-11-10
申请号：US15175292
申请日：2016-06-07
发明人： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC分类号： C07D317/72
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
-
公开(公告)号：US20160251352A1
公开(公告)日：2016-09-01
申请号：US15148276
申请日：2016-05-06
发明人： Hiroshi NARA , Masaki DAINI , Akira KAIEDA , Taku KAMEI , Toshihiro IMAEDA , Fumiaki KIKUCHI
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.04 秒)
