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    Method of preparing granules of dipeptide
    1.
    发明授权
    Method of preparing granules of dipeptide 失效
    制备二肽颗粒的方法

    公开(公告)号：US5358186A

    公开(公告)日：1994-10-25

    申请号：US112981

    申请日：1993-08-30

    申请人： Takehiko Kataoka ,  Tadashi Takemoto ,  Harutoshi Ohura ,  Makoto Nishikawa

    发明人： Takehiko Kataoka ,  Tadashi Takemoto ,  Harutoshi Ohura ,  Makoto Nishikawa

    IPC分类号： A23L1/22 ,  A23L1/00 ,  A23L1/236 ,  A23P1/02 ,  C07K5/075 ,  B02C7/00

    CPC分类号： A23L27/32 ,  A23P10/25

    摘要： In producing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a particle size of falling within a determined particle size range by compaction granulation, formation of fine powdery .alpha.-APM is prevented by breaking the compacted .alpha.-APM so that the one-pass yield of the granules is elevated and the sieving efficiency is elevated. In a method of preparing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester by compaction granulation of the ester singly or along with a vehicle of not more than the same amount of the ester, after the compaction or after having roughly broken the compacted material, the material is broken down so as to pass through a screen or perforated plate having pores with a diameter falling within the range of from 1 mm to 10 mm and then further broken and classified.

    摘要翻译： 在通过压实造粒生产粒径处于确定的粒度范围内的α-L-天冬氨酰基-L-苯丙氨酸甲酯的颗粒中，通过打破压实的α-APM来防止细粉末α-APM的形成， 颗粒的单程产率提高，筛分效率提高。 在制备α-L-天冬氨酰基-L-苯丙氨酸甲酯的颗粒的方法中，通过单独压制酯化或与不超过相同量的酯的载体一起制成颗粒，在压实之后或在大致破裂之后 将材料分解，通过具有直径在1mm至10mm范围内的孔的筛网或多孔板，然后进一步破碎分级。

    Distillation method of separating organic solvents
    2.
    发明授权
    Distillation method of separating organic solvents 失效
    分离有机溶剂的蒸馏方法

    公开(公告)号：US5275702A

    公开(公告)日：1994-01-04

    申请号：US928298

    申请日：1992-08-12

    申请人： Takehiko Kataoka ,  Haruo Kawasaki ,  Harutoshi Ohura ,  Yoshinobu Uchida ,  Akihiko Yasaki ,  Shinichi Kishimoto

    发明人： Takehiko Kataoka ,  Haruo Kawasaki ,  Harutoshi Ohura ,  Yoshinobu Uchida ,  Akihiko Yasaki ,  Shinichi Kishimoto

    IPC分类号： B01D3/14 ,  B01D3/36 ,  C07B63/00 ,  C07C7/06 ,  C07C15/06 ,  C07C51/46 ,  C07C53/08 ,  C07K5/075

    CPC分类号： C07K5/0613 ,  B01D3/36 ,  C07C51/46

    摘要： The present invention discloses a method to separate each component from a mixed solution of organic solvents obtained during the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is useful as a sweetener, namely, a mixed solution of acetic acid and toluene or a mixed solution of acetic acid, toluene and formic acid, recovering each component with a high recovery ratio with as small number of operations as possible. The method rationalizes the process and is highly valuable in practical use.When each component is separated and recovered from a mixed solution containing acetic acid and toluene as the main components, acetic acid and toluene are separated by azeotropic distillation using water as an azeotropic solvent, and when each component is separated and recovered from a mixed solution containing acetic acid, toluene and formic acid as the main components, (a) the mixed solution is distilled and formic acid is recovered from the top of the column and a mixed solution of acetic acid and toluene is recovered from the bottom of the column; and (b) the mixed solution obtained from the bottom is distilled by using water as an azeotropic solvent and toluene is recovered from the top of the column and acetic acid is recovered from the bottom of the column.

    摘要翻译： 本发明公开了一种将（α）-L-天冬氨酰基-L-苯丙氨酸甲酯制备期间获得的有机溶剂的混合溶液中的每种成分分离的方法，其可用作甜味剂即乙酸混合溶液 酸和甲苯或乙酸，甲苯和甲酸的混合溶液，以尽可能少的操作以高回收率回收每种组分。 该方法使过程合理化，在实际应用中非常有价值。 当从含有乙酸和甲苯作为主要组分的混合溶液中分离和回收各成分时，使用水作为共沸溶剂通过共沸蒸馏分离乙酸和甲苯，并且当将每种组分从含有 乙酸，甲苯和甲酸为主要成分，（a）蒸馏出混合溶液，从塔顶回收甲酸，从塔底回收乙酸和甲苯的混合溶液; 和（b）通过使用水作为共沸溶剂蒸馏从底部获得的混合溶液，并从塔顶回收甲苯，从塔底回收乙酸。