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1.发明申请WRINKLE REDUCTION AGENT, LIPOLYSIS ACCELERATOR, COMPOSITION FOR EXTERNAL USE ON SKIN, AND FOOD OR BEVERAGE COMPOSITION 审中-公开消除皱缩剂，脂肪加速器，外用于皮肤的组合物，食品或饮料组合物公开(公告)号：US20090149550A1
公开(公告)日：2009-06-11
申请号：US12335326
申请日：2008-12-15
申请人： Jun SUGITA , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
发明人： Jun SUGITA , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K8/35 , A61K36/906 , A61Q19/08 , A23V2250/21 , A23V2200/318 , A23V2200/332
摘要： An antiwrinkle agent, lipolysis promoter, external composition for skin, and food and beverage composition having for an active ingredient thereof a compound represented by general formula (1): (wherein R represents a hydrogen atom or an acyl group having 2 to 20 carbon atoms) or an extract obtained from guinea ginger and/or an acylation treatment product of said extract.
摘要翻译： 抗皱皱剂，脂肪分解促进剂，皮肤外用组合物，以及食品饮料组合物，其活性成分为通式（1）表示的化合物：（式中，R表示氢原子或碳原子数2〜20的酰基） ）或从豚鼠获得的提取物和/或所述提取物的酰化处理产物。
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2.发明申请Wrinkle Reduction Agent, Lipolysis Accelerator, Composition for External Use on Skin, and Food or Beverage Composition 审中-公开抗皱剂，脂解促进剂，皮肤外用组合物，食品或饮料组合物公开(公告)号：US20070259057A1
公开(公告)日：2007-11-08
申请号：US11661401
申请日：2005-08-29
申请人： Jun Sugita , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
发明人： Jun Sugita , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
IPC分类号： A61K36/906 , A61K31/121 , A61K8/35 , A61P3/04 , A61Q19/00
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K8/35 , A61K36/906 , A61Q19/08 , A23V2250/21 , A23V2200/318 , A23V2200/332
摘要： An antiwrinkle agent, lipolysis promoter, external composition for skin, and food and beverage composition having for an active ingredient thereof a compound represented by general formula (1): (wherein R represents a hydrogen atom or an acyl group having 2 to 20 carbon atoms) or an extract obtained from guinea ginger and/or an acylation treatment product of said extract.
摘要翻译： 抗皱皱剂，脂肪分解促进剂，皮肤外用组合物，以及食品饮料组合物，其活性成分为通式（1）表示的化合物：（式中，R表示氢原子或碳原子数2〜20的酰基） ）或从豚鼠获得的提取物和/或所述提取物的酰化处理产物。
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3.发明申请ANTIWRINKLE AGENT, LIPOLYSIS PROMOTER, EXTERNAL COMPOSITION FOR SKIN AND FOOD AND BEVERAGE COMPOSITION 有权抗皱剂，脂肪促进剂，外用组合物，用于皮肤和食品和饮料组合物公开(公告)号：US20120322888A1
公开(公告)日：2012-12-20
申请号：US13595215
申请日：2012-08-27
申请人： Jun Sugita , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
发明人： Jun Sugita , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K8/35 , A61K36/906 , A61Q19/08 , A23V2250/21 , A23V2200/318 , A23V2200/332
摘要： An antiwrinkle agent, lipolysis promoter, external composition for skin, and food and beverage composition having for an active ingredient thereof a compound represented by general formula (1): (wherein R represents a hydrogen atom or an acyl group having 2 to 20 carbon atoms). or an extract obtained from guinea ginger and/or an acylation treatment product of said extract.
摘要翻译： 抗皱皱剂，脂肪分解促进剂，皮肤外用组合物，以及食品饮料组合物，其活性成分为通式（1）表示的化合物：（式中，R表示氢原子或碳原子数2〜20的酰基） ）。 或从所述提取物获得的提取物和/或所述提取物的酰化处理产物。
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公开(公告)号：US08273719B2
公开(公告)日：2012-09-25
申请号：US12465780
申请日：2009-05-14
申请人： Takeshi Ikemoto , Aya Komiya , Akinori Haratake
发明人： Takeshi Ikemoto , Aya Komiya , Akinori Haratake
摘要： An antiwrinkle agent which is highly effective in alleviating wrinkles caused by the photoaging. The present invention relates to an antiwrinkle agent comprising an eugenyl glycoside.
摘要翻译： 一种抗皱消炎剂，其有效减轻由光老化引起的皱纹。 本发明涉及包含丁烯基糖苷的抗皱胶剂。
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公开(公告)号：US20080242849A1
公开(公告)日：2008-10-02
申请号：US10586877
申请日：2005-01-21
申请人： Takeshi Ikemoto , Aya Komiya , Akinori Haratake
发明人： Takeshi Ikemoto , Aya Komiya , Akinori Haratake
摘要： An antiwrinkle agent which is highly effective in alleviating wrinkles caused by the photoaging. The present invention relates to an antiwrinkle agent comprising an eugenyl glycoside.
摘要翻译： 一种抗皱消炎剂，其有效减轻由光老化引起的皱纹。 本发明涉及包含丁烯基糖苷的抗皱胶剂。
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6.发明授权Antiwrinkle agent, lipolysis promoter, external composition for skin and food and beverage composition 有权抗皱剂，脂解促进剂，皮肤外用组合物和食品饮料组成公开(公告)号：US08445005B2
公开(公告)日：2013-05-21
申请号：US13595215
申请日：2012-08-27
申请人： Jun Sugita , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
发明人： Jun Sugita , Takeshi Ikemoto , Yumiko Akazawa , Yurie Kobayashi , Mitsumasa Mitani , Akinori Haratake , Aya Komiya
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K8/35 , A61K36/906 , A61Q19/08 , A23V2250/21 , A23V2200/318 , A23V2200/332
摘要： An antiwrinkle agent, lipolysis promoter, external composition for skin, and food and beverage composition having for an active ingredient thereof a compound represented by general formula (1): (wherein R represents a hydrogen atom or an acyl group having 2 to 20 carbon atoms) or an extract obtained from guinea ginger and/or an acylation treatment product of said extract.
摘要翻译： 抗皱皱剂，脂肪分解促进剂，皮肤外用组合物，以及食品饮料组合物，其活性成分为通式（1）表示的化合物：（式中，R表示氢原子或碳原子数2〜20的酰基） ）或从豚鼠获得的提取物和/或所述提取物的酰化处理产物。
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公开(公告)号：US08084064B2
公开(公告)日：2011-12-27
申请号：US12500054
申请日：2009-07-09
IPC分类号： A61K36/537
摘要： The present invention provides an antiwrinkle agent and skin cosmetic composition having excellent alleviating effects on wrinkles appearing due to aging, and especially at exposed locations of skin, and a high degree of safety.The present invention relates to an antiwrinkle agent and skin cosmetic composition comprising a sclareol derivative represented by the following structural formula (1).
摘要翻译： 本发明提供对由于老化引起的皱纹，特别是在皮肤的暴露位置以及高度安全性的皱纹的缓解作用，具有优异的抗皱纹剂和皮肤化妆品组合物。 本发明涉及包含由以下结构式（1）表示的香紫苏醇衍生物的抗皱纹剂和皮肤化妆品组合物。
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公开(公告)号：US07037489B2
公开(公告)日：2006-05-02
申请号：US10169040
申请日：2000-12-15
申请人： Hideyo Uchiwa , Sachiyo Hirotsu , Akinori Haratake , Takeshi Ikemoto , Junichi Matsui , Shunsuke Yamazaki , Masaki Yoshida , Motoi Hayase
发明人： Hideyo Uchiwa , Sachiyo Hirotsu , Akinori Haratake , Takeshi Ikemoto , Junichi Matsui , Shunsuke Yamazaki , Masaki Yoshida , Motoi Hayase
CPC分类号： C07C69/60 , A61K8/39 , A61K8/671 , A61K31/22 , A61K31/225 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/08 , A61Q19/10
摘要： Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein R1 represents C1-4 alkylene; R2 and R3 represent each liner or branched C1-8 alkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.
摘要翻译： 皮肤外用剂组合物和药物，其特征在于含有由以下通式（1）表示的富马酸二酯衍生物，其中R 1表示C 1-4烷基; R 2和R 3代表每个内衬或支链C 1-8烷基; n为2〜5的整数， 其提供表皮屏障功能增强剂和皮肤外用剂组合物，其具有高安全性，快速缓解表皮渗透屏障功能障碍并具有保持皮肤处于美观健康状态的效果; 与HB-EFG表达诱导剂加速表皮转换，调节过度表皮增生的双调蛋白表达抑制剂和视黄酸或其衍生物一起使用的药剂可以防止由视黄酸或其衍生物引起的皮肤裂伤; 以及能够改善皮肤新陈代谢抑制和与老化相关的变薄的皮肤老化缓解剂。
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公开(公告)号：US07611737B2
公开(公告)日：2009-11-03
申请号：US11579094
申请日：2005-04-28
IPC分类号： A61K36/537
摘要： The present invention provides an antiwrinkle agent and skin cosmetic composition having excellent alleviating effects on wrinkles appearing due to aging, and especially at exposed locations of skin, and a high degree of safety.The present invention relates to an antiwrinkle agent and skin cosmetic composition comprising a sclareol derivative represented by the following structural formula (1).
摘要翻译： 本发明提供对由于老化引起的皱纹，特别是在皮肤的暴露位置以及高度安全性的皱纹的缓解作用，具有优异的抗皱纹剂和皮肤化妆品组合物。 本发明涉及包含由以下结构式（1）表示的香紫苏醇衍生物的抗皱纹剂和皮肤化妆品组合物。
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公开(公告)号：US07763263B2
公开(公告)日：2010-07-27
申请号：US11400651
申请日：2006-04-07
申请人： Hideyo Uchiwa , Sachiyo Hirotsu , Akinori Haratake , Takeshi Ikemoto , Junichi Matsui , Shunsuke Yamazaki , Masaki Yoshida , Motoi Hayase
发明人： Hideyo Uchiwa , Sachiyo Hirotsu , Akinori Haratake , Takeshi Ikemoto , Junichi Matsui , Shunsuke Yamazaki , Masaki Yoshida , Motoi Hayase
摘要： The present invention provides a method for enhancing epidermal permeability barrier function of the aged skin, which includes the step of externally administering to the aged skin an amount of a fumaric acid diester derivative expressed by the following general formula (1) as an active ingredient wherein R1 represents a C1-4 alkylene group; R2 and R3 each represents a linear or branched C1-8 alkyl group; and n is an integer of 2 to 5.
摘要翻译： 本发明提供了一种增强老化皮肤的表皮渗透阻断功能的方法，其包括向老化皮肤外部施用一定量的由以下通式（1）表示的富马酸二酯衍生物作为活性成分的步骤，其中 R1表示C1-4亚烷基; R2和R3各自表示直链或支链C 1-8烷基; n为2〜5的整数。
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