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公开(公告)号：US20090326247A1
公开(公告)日：2009-12-31
申请号：US12514090
申请日：2007-10-24
申请人： Takeshi Kakimoto , Yoji Aoki , Daisuke Ura , Miki Enomoto , Hisato Kamekawa , Toshio Kitashima
发明人： Takeshi Kakimoto , Yoji Aoki , Daisuke Ura , Miki Enomoto , Hisato Kamekawa , Toshio Kitashima
IPC分类号： C07D333/42
CPC分类号： C07B61/00 , C07D333/36 , Y02P20/55
摘要： The present invention provides a method of producing a 2-alkyl-3-aminothiophene derivative represented by formula (2) by reducing at least one of the 2-alkenyl-3-aminothiophene derivatives represented by formulae (1a) to (1d), or a mixture thereof, or a salt thereof, without using a protecting group for an amino group: wherein in formulae (1a) to (1d), R1 to R4 each independently represents a hydrogen atom, an alkyl group of 1 to 12 carbon atoms or the like; and R5 and R6 each independently represents a hydrogen atom, a halogen atom, an alkyl group of 1 to 12 carbon atoms or the like. According to the invention, a 2-alkyl-3-aminothiophene derivative usable as an intermediate of agricultural chemicals can be produced by a cost-efficient industrial process, without the use of a high-cost protective group for an amino group.
摘要翻译： 本发明提供通过还原由式（1a）〜（1d）表示的2-烯基-3-氨基噻吩衍生物中的至少一种或式（1a）〜（1d）所示的2-烷基-3-氨基噻吩衍生物，或 其混合物或其盐，不使用氨基的保护基团：其中在式（1a）至（1d）中，R 1至R 4各自独立地表示氢原子，1至12个碳原子的烷基或 类似; R 5和R 6各自独立地表示氢原子，卤素原子，碳原子数1〜12的烷基等。 根据本发明，可以通过成本效益高的工业过程制造可用作农药中间体的2-烷基-3-氨基噻吩衍生物，而不使用高成本的氨基保护基。
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公开(公告)号：US07560593B2
公开(公告)日：2009-07-14
申请号：US12278495
申请日：2007-02-07
IPC分类号： C07C273/18
CPC分类号： C07C273/18 , C07B43/00 , C07C275/70
摘要： Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a process for producing nitroisourea derivatives represented by the following general formula (3), which is characterized in that nitroisourea derivatives represented by the following general formula (1) and amines represented by the following general formula (2) or a salt thereof are reacted in the presence of a catalytic amount of a hydrogen carbonate,
摘要翻译： 公开了生产具有杀虫活性的硝基胍衍生物所必需的硝基异脲衍生物的改进方法。 具体公开了下述通式（3）表示的硝基异脲衍生物的制造方法，其特征在于，将下述通式（1）表示的硝基异
脲衍生物或下述通式（2）表示的胺或其盐 在催化量的碳酸氢盐存在下反应，-
公开(公告)号：US20090018363A1
公开(公告)日：2009-01-15
申请号：US12278495
申请日：2007-02-07
IPC分类号： C07C249/00
CPC分类号： C07C273/18 , C07B43/00 , C07C275/70
摘要： Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a process for producing nitroisourea derivatives represented by the following general formula (3), which is characterized in that nitroisourea derivatives represented by the following general formula (1) and amines represented by the following general formula (2) or a salt thereof are reacted in the presence of a catalytic amount of a hydrogen carbonate,
摘要翻译： 公开了生产具有杀虫活性的硝基胍衍生物所必需的硝基异脲衍生物的改进方法。 具体公开了下述通式（3）表示的硝基异脲衍生物的制造方法，其特征在于，将下述通式（1）表示的硝基异
脲衍生物或下述通式（2）表示的胺或其盐 在催化量的碳酸氢盐存在下反应，-
公开(公告)号：US20050176971A1
公开(公告)日：2005-08-11
申请号：US10517494
申请日：2003-07-22
申请人： Daisuke Ura , Hiroyuki Katsuta , Toshio Kitashima , Kenichi Sato
发明人： Daisuke Ura , Hiroyuki Katsuta , Toshio Kitashima , Kenichi Sato
IPC分类号： C07D333/36
CPC分类号： C07D333/36
摘要： A method for reducing a sulfur-containing compound by hydrogenation using a noble metal catalyst which method is exemplified by an industrial method for producing a 2-alkyl-3-aminothiophene derivative with high economical efficiency by hydrogenating a 2-alkenyl-3-aminothiophene derivative using the noble metal catalyst. 2-Alkyl-3-aminothiophene derivatives are useful compounds in the fields of medicine and agriculture, and in particular, useful in bactericides for agriculture or gardening, or intermediates of the bactericides. The hydrogenation reaction temperature is controlled at 150° C. to 300° C. and the method allows the used noble metal catalyst to be recovered and reused.
摘要翻译： 使用贵金属催化剂通过氢化还原含硫化合物的方法，该方法的例子是通过氢化2-链烯基-3-氨基噻吩衍生物，经济地制备2-烷基-3-氨基噻吩衍生物的工业方法 使用贵金属催化剂。 2-烷基-3-氨基噻吩衍生物是医药和农业领域中有用的化合物，特别是用于农业或园艺的杀菌剂或杀菌剂的中间体。 将氢化反应温度控制在150℃至300℃，并且该方法允许回收和重复使用所用的贵金属催化剂。
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公开(公告)号：US07196207B2
公开(公告)日：2007-03-27
申请号：US10517494
申请日：2003-07-22
申请人： Daisuke Ura , Hiroyuki Katsuta , Toshio Kitashima , Kenichi Sato
发明人： Daisuke Ura , Hiroyuki Katsuta , Toshio Kitashima , Kenichi Sato
IPC分类号： C07D333/36
CPC分类号： C07D333/36
摘要： A method for reducing a sulfur-containing compound by hydrogenation using a noble metal catalyst which method is exemplified by an industrial method for producing a 2-alkyl-3-aminothiophene derivative with high economical efficiency by hydrogenating a 2-alkenyl-3-aminothiophene derivative using the noble metal catalyst. 2-Alkyl-3-aminothiophene derivatives are useful compounds in the fields of medicine and agriculture, and in particular, useful in bactericides for agriculture or gardening, or intermediates of the bactericides. The hydrogenation reaction temperature is controlled at 150° C. to 300° C. and the method allows the used noble metal catalyst to be recovered and reused.
摘要翻译： 使用贵金属催化剂通过氢化还原含硫化合物的方法，该方法的例子是通过氢化2-链烯基-3-氨基噻吩衍生物，经济地制备2-烷基-3-氨基噻吩衍生物的工业方法 使用贵金属催化剂。 2-烷基-3-氨基噻吩衍生物是医药和农业领域中有用的化合物，特别是用于农业或园艺的杀菌剂或杀菌剂的中间体。 将氢化反应温度控制在150℃至300℃，并且该方法允许回收和重复使用所用的贵金属催化剂。
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公开(公告)号：US5312977A
公开(公告)日：1994-05-17
申请号：US19116
申请日：1993-02-17
申请人： Makoto Yanaka , Tooru Miyahara , Daisuke Ura , Nobuhiro Fukuhara
发明人： Makoto Yanaka , Tooru Miyahara , Daisuke Ura , Nobuhiro Fukuhara
IPC分类号： C07C227/42 , C12P13/22 , C07C229/28
CPC分类号： C07C227/42 , C12P13/222
摘要： L-Phenylalanine is isolated in pure form from an aqueous solution thereof containing cinnamic acid by subjecting the aqueous solution to toluene extraction to extract cinnamic acid therefrom; separating the toluene phase; and then concentrating the aqueous phase, until crystals of L-phenylalanine form therein, while concurrently separating the crystalline L-phenylalanine from the liquid aqueous phase.
摘要翻译： 通过使水溶液进行甲苯萃取从其中提取肉桂酸，从含有肉桂酸的水溶液中分离出纯净的L-苯丙氨酸， 分离甲苯相; 然后浓缩水相，直到形成L-苯丙氨酸晶体，同时从液体水相中同时分离结晶L-苯丙氨酸。
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公开(公告)号：US5382517A
公开(公告)日：1995-01-17
申请号：US20446
申请日：1993-02-22
CPC分类号： C12P13/06
摘要： The invention relates to a process for preparing L-serine from glycine and formaldehyde in the presence of cells of a microorganism or a cell-treated product having a serine hydroxymethyl transferase activity by an enzymatic method.
摘要翻译： 本发明涉及通过酶法在微生物细胞或具有丝氨酸羟甲基转移酶活性的细胞处理产物存在下从甘氨酸和甲醛制备L-丝氨酸的方法。
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公开(公告)号：US6118007A
公开(公告)日：2000-09-12
申请号：US46588
申请日：1998-03-24
申请人： Koichi Ebihara , Tatsuo Kaiho , Michihiko Miyamoto , Daisuke Ura
发明人： Koichi Ebihara , Tatsuo Kaiho , Michihiko Miyamoto , Daisuke Ura
IPC分类号： C07D277/28 , C07D277/32 , C07D407/06 , C07D417/06 , C07D263/30 , C07D333/22
CPC分类号： C07D277/32 , C07D407/06 , C07D417/06
摘要： A process, as a substitute for hydrolysis, for preparing a nitroguanidine derivative represented by the following formula (2): ##STR1## wherein A represents a substituted or unsubstituted aromatic or non-aromatic hydrocarbon ring, a substituted or unsubstituted aromatic or non-aromatic heterocycle, a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl or alkynyl group; and R.sub.2 represents a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl, alkenyl or alkynyl group, which comprises reacting a compound represented by the following formula (1): ##STR2## wherein R.sub.1 represents a substituted or unsubstituted, linear or cyclic C.sub.1-10 alkyl group and A and R.sub.2 have the same meanings as defined above, with ammonia, a primary amine or a secondary amine, or a salt thereof.
摘要翻译： 用于制备由下式（2）表示的硝基胍衍生物的方法作为水解的替代方法：其中A表示取代或未取代的芳族或非芳族烃环，取代或未取代的芳族或非芳族杂环， 氢原子或取代或未取代的烷基，烯基或炔基; R 2表示氢原子，取代或未取代的C 1-6烷基，烯基或炔基，其包括使下式（1）表示的化合物：其中R 1表示取代或未取代的直链或环状C 1-10烷基 基团和A和R 2具有与上述相同的含义，与氨，伯胺或仲胺或其盐。
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