公开(公告)号：US11041864B2

公开(公告)日：2021-06-22

申请号：US13979133

申请日：2012-01-10

申请人： Takeshi Matsuya ,  Yoshikazu Okamura ,  Ralf Thomae ,  Eberhard Spanuth ,  Boris Ivandic ,  Kamon Shirakawa ,  Shigeatsu Endo

发明人： Takeshi Matsuya ,  Yoshikazu Okamura ,  Ralf Thomae ,  Eberhard Spanuth ,  Boris Ivandic ,  Kamon Shirakawa ,  Shigeatsu Endo

IPC分类号： G01N33/53 ,  G01N33/68

摘要： Disclosed is a prediction method for the prognosis of sepsis comprising measuring an sCD14-ST level in a sample. sCD14-ST, to be measured in the present invention, is a marker superior to procalcitonin, known as a marker to predict the prognosis in sepsis patients.

公开(公告)号：US20130288276A1

公开(公告)日：2013-10-31

申请号：US13979133

申请日：2012-01-10

申请人： Takeshi Matsuya ,  Yoshikazu Okamura ,  Ralf Thomae ,  Eberhard Spanuth ,  Boris Ivandic ,  Kamon Shirakawa ,  Shigeatsu Endo

发明人： Takeshi Matsuya ,  Yoshikazu Okamura ,  Ralf Thomae ,  Eberhard Spanuth ,  Boris Ivandic ,  Kamon Shirakawa ,  Shigeatsu Endo

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/70596 ,  G01N2800/26 ,  G01N2800/52

摘要： Disclosed is a prediction method for the prognosis of sepsis comprising measuring an sCD14-ST level in a sample. sCD14-ST, to be measured in the present invention, is a marker superior to procalcitonin, known as a marker to predict the prognosis in sepsis patients.

摘要翻译： 公开了一种用于预测败血症的预测方法，其包括测量样品中的sCD14-ST水平。 在本发明中测量的sCD14-ST是优于降钙素原的标记，被称为预测败血症患者预后的标志物。

公开(公告)号：US20110129936A1

公开(公告)日：2011-06-02

申请号：US13020346

申请日：2011-02-03

申请人： Eberhard Spanuth ,  Boris Ivandic

发明人： Eberhard Spanuth ,  Boris Ivandic

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/86 ,  G01N2333/4712 ,  G01N2333/58 ,  G01N2333/75 ,  G01N2800/226

摘要： The present invention relates to a method of diagnosing acute pulmonary embolism (PE) in a subject including a) determining the amount of fibrin-fibrinogen degradation products, in particular D-dimer in a sample of the subject; b) determining the amount of a natriuretic peptide in a sample of the subject; c) determining the amount of a cardiac troponin in a sample of the subject; and d) comparing the amounts determined in steps a) to c) to reference amounts, thereby establishing the diagnosis. Included is also a method of deciding on a therapy of a subject diagnosed with PE and a method of monitoring the therapy.

摘要翻译： 本发明涉及一种诊断受试者的急性肺栓塞（PE）的方法，包括：a）确定受试者样品中纤维蛋白原纤维蛋白原降解产物，特别是D-二聚体的量; b）确定受试者样品中利尿钠肽的量; c）确定受试者样品中心肌肌钙蛋白的量; 和d）将步骤a）至c）中确定的量与参考量进行比较，从而建立诊断。 包括也是确定被诊断为PE的受试者的治疗方法和监测治疗的方法。

公开(公告)号：US20130236916A1

公开(公告)日：2013-09-12

申请号：US13869464

申请日：2013-04-24

申请人： Eberhard Spanuth ,  Boris Ivandic

发明人： Eberhard Spanuth ,  Boris Ivandic

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/86 ,  G01N2333/4712 ,  G01N2333/58 ,  G01N2333/75 ,  G01N2800/226

摘要： The present invention relates to a method of diagnosing acute pulmonary embolism (PE) in a subject including a) determining the amount of fibrin-fibrinogen degradation products, in particular D-dimer in a sample of the subject; b) determining the amount of a natriuretic peptide in a sample of the subject; c) determining the amount of a cardiac troponin in a sample of the subject; and d) comparing the amounts determined in steps a) to c) to reference amounts, thereby establishing the diagnosis. Included is also a method of deciding on a therapy of a subject diagnosed with PE and a method of monitoring the therapy.

摘要翻译： 本发明涉及一种诊断受试者的急性肺栓塞（PE）的方法，包括：a）确定受试者样品中纤维蛋白原纤维蛋白原降解产物，特别是D-二聚体的量; b）确定受试者样品中利尿钠肽的量; c）确定受试者样品中心肌肌钙蛋白的量; 和d）将步骤a）至c）中确定的量与参考量进行比较，从而建立诊断。 包括也是确定被诊断为PE的受试者的治疗方法和监测治疗的方法。

公开(公告)号：US08444932B2

公开(公告)日：2013-05-21

申请号：US13020346

申请日：2011-02-03

申请人： Eberhard Spanuth ,  Boris Ivandic

发明人： Eberhard Spanuth ,  Boris Ivandic

IPC分类号： G01N33/68 ,  G01N33/48

CPC分类号： G01N33/6893 ,  G01N33/86 ,  G01N2333/4712 ,  G01N2333/58 ,  G01N2333/75 ,  G01N2800/226

摘要： The present invention relates to a method of diagnosing acute pulmonary embolism (PE) in a subject including a) determining the amount of fibrin-fibrinogen degradation products, in particular D-dimer in a sample of the subject; b) determining the amount of a natriuretic peptide in a sample of the subject; c) determining the amount of a cardiac troponin in a sample of the subject; and d) comparing the amounts determined in steps a) to c) to reference amounts, thereby establishing the diagnosis. Included is also a method of deciding on a therapy of a subject diagnosed with PE and a method of monitoring the therapy.

摘要翻译： 本发明涉及一种诊断受试者的急性肺栓塞（PE）的方法，包括：a）确定受试者样品中纤维蛋白原纤维蛋白原降解产物，特别是D-二聚体的量; b）确定受试者样品中利尿钠肽的量; c）确定受试者样品中心肌肌钙蛋白的量; 和d）将步骤a）至c）中确定的量与参考量进行比较，从而建立诊断。 包括也是确定被诊断为PE的受试者的治疗方法和监测治疗的方法。