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公开(公告)号:US5247102A
公开(公告)日:1993-09-21
申请号:US778927
申请日:1991-12-05
申请人: Tamas Kallay , Gyorgy Lanyi , Laszlo Ledniczky , Lajos Imrei , Gyorgy Hoffmann , Maria Sziladi , Eva Somfai , Tibor Montay
发明人: Tamas Kallay , Gyorgy Lanyi , Laszlo Ledniczky , Lajos Imrei , Gyorgy Hoffmann , Maria Sziladi , Eva Somfai , Tibor Montay
IPC分类号: A61K31/35 , A61K31/352 , A61P3/02 , A61P43/00 , C07D311/36
CPC分类号: C07D311/36
摘要: The invention relates to a process for the preparation of pure isoflavone derivatives of the general formula (I), ##STR1## wherein R stands for hydrogen or isopropyl,R.sup.2 and R.sup.3 stand for hydrogen or C.sub.1-2 alkoxy by reacting a rezorcinol-derivative of the general formula (III) ##STR2## wherein R.sup.2 and R.sup.3 are as given above with ethyl-orthoformiate of the formula (IV)(C.sub.2 H.sub.5 O).sub.3l CH (IV)in the presence of a base and optionally by alkylating the product.
摘要翻译: PCT No.PCT / HU90 / 00023 Sec。 371 1991年12月5日第 102(e)1991年12月5日,PCT提交1990年4月6日PCT公布。 WO91 / 15483 PCT出版物 日本公开日1991年10月17日。本发明涉及制备通式(I)的纯异黄酮衍生物的方法,其中R代表氢或异丙基,R2和R3代表氢或C1 (III)的间苯二酚衍生物,其中R 2和R 3如上所述与式(IV)(C 2 H 5 O)3 CH(IV)的原甲酸酯在式 碱的存在和任选地通过烷基化产物。
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公开(公告)号:US5235109A
公开(公告)日:1993-08-10
申请号:US793422
申请日:1991-12-11
申请人: Gyorgy Lanyi , Tamas Kallay , Laszlo Ledniczky , Lajos Imrei , Eva Somfai , Tibor Montay , Robert Gepesz , Valeria Denes nee Lustig , Laszlo rvai
发明人: Gyorgy Lanyi , Tamas Kallay , Laszlo Ledniczky , Lajos Imrei , Eva Somfai , Tibor Montay , Robert Gepesz , Valeria Denes nee Lustig , Laszlo rvai
IPC分类号: C07C45/46 , C07C20060101 , C07C45/45 , C07C45/68 , C07C49/825 , C07C49/83 , C07C49/84
摘要: The invention relates to an improved, large scale process for the preparation of compounds of formula (I) ##STR1## wherein R is halogen atom or hydroxyl,R.sup.2 is hydrogen atom or hydroxyl,R.sup.3 and R.sup.4 are hydrogen or alkoxy having 1-6 carbon atoms.
摘要翻译: PCT No.PCT / HU90 / 00026 Sec。 371日期1991年12月11日 102(e)日期1991年12月11日PCT 1990年4月18日PCT PCT。 WO91 / 16293 PCT出版物 1991年10月31日的日期。本发明涉及制备式(I)化合物的改进的大规模方法,其中R是卤素原子或羟基,R 2是氢原子或羟基,R 3和 R4是氢或具有1-6个碳原子的烷氧基。
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公开(公告)号:US5449828A
公开(公告)日:1995-09-12
申请号:US353816
申请日:1994-12-09
申请人: Zsuzsanna Nad , Tamas Kallay , Maria Sziladi , Tibor Montay
发明人: Zsuzsanna Nad , Tamas Kallay , Maria Sziladi , Tibor Montay
IPC分类号: C07C211/63 , C07C209/06 , C07C209/08 , C07C209/68 , C07C211/27 , C07C211/29 , C07C209/02
CPC分类号: C07C209/08 , C07C211/27 , C07C211/29
摘要: The present invention relates to a process for the preparation of L-isomer of propargyl-ammonium-chloride derivatives of the formula (I) ##STR1## by decomposing D-tartarte of L-isomer of the amine of the general ##STR2## wherein y is hydrogen or fluoro and by reacting the obtained L-issomer amine of the formula (II) in the presence of a base with a halide of the formula (V), X--CH.sub.2 --C.ident.CCH wherein X is halogen and by reacting the so obtained L-isomer of the Formula (III) ##STR3## with hydrogen-chloride in an organic solvent, wherein x is a halogen atom,y is a hydrogen or fluorine atom.
摘要翻译: 本发明涉及通过将通用化合物(I)的胺的L-异构体的D-异构体分解而制备式(I)的炔丙基氯化铵衍生物的L-异构体的方法 (II)其中y是氢或氟,并且通过使式(II)所得的L-取代的胺在碱的存在下与式(V)的卤化物反应,X-CH 2 -C = CCH,其中X 是通过使所得到的式(III)的III型异构体在有机溶剂中与氯化氢反应,其中x是卤素原子,y是氢或氟原子。
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公开(公告)号:US4086246A
公开(公告)日:1978-04-25
申请号:US682033
申请日:1976-04-30
申请人: Geza Toth , Istvan Toth , Tibor Montay
发明人: Geza Toth , Istvan Toth , Tibor Montay
IPC分类号: C07C275/30 , C07C67/00 , C07C239/00 , C07C271/08 , C07C273/02 , C07C273/18 , C07C275/40 , C07D235/32 , C07D277/28 , C07D307/86 , C07D317/24 , C07D307/87
CPC分类号: C07D235/32 , C07C273/1809 , C07D307/86 , C07D317/24
摘要: A process for the preparation of a compound of the formula: ##STR1## wherein R.sup.1 is alkyl, alkyl substituted by halogen, alkyl substituted by alkoxy, aryl, aryl substituted by halogen, aryl substituted by alkyl, aryl substituted by alkoxy, aralkyl, aralkyl substituted by alkoxy, cycloalkyl, cycloalkyl substituted by halogen, cycloalkyl substituted by alkyl or cycloalkyl substituted by alkoxy, andR.sup.2 is an aromatic group, an aromatic group substituted by alkyl, an aromatic group substituted by halogen, an aromatic group substituted by alkoxy, a heteroaromatic group, a heteroaromatic group substituted by alkyl, a heteroaromatic group substituted by halogen, or a heteroaromatic group substituted by alkoxy, by the reaction of phosgene with a phenol of the formula:R.sup.2 -OHand further by the reaction of a primary amine of the formula:R'--NH.sub.2,reacting all three of the abovementioned reactants solution in a common water-immiscible organic solvent in the same reaction vessel at the same time in the presence of an acid binding agent to yield the compound of formula ##STR2##
摘要翻译: 一种制备下式化合物的方法:其中R1是烷基,被卤素取代的烷基,被烷氧基取代的烷基,芳基,被卤素取代的芳基,被烷基取代的芳基,被烷氧基取代的芳基,芳烷基,芳烷基 被烷氧基取代的环烷基,被烷基取代的环烷基或被烷氧基取代的环烷基,R2是芳基,被烷基取代的芳基,被卤素取代的芳基,被烷氧基取代的芳基, 杂芳基,被烷基取代的杂芳基,被卤素取代的杂芳基或被烷氧基取代的杂芳基,通过光气与下式的苯酚反应:
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