公开(公告)号：US20170320812A1

公开(公告)日：2017-11-09

申请号：US15523864

申请日：2015-11-14

申请人： Taminco BVBA

发明人： Kristof Moonen ,  Kim Dumoleijn ,  Laura Prati ,  Alberto Villa

IPC分类号： C07C209/26 ,  A01N37/42 ,  C07B43/04 ,  C07C249/04

CPC分类号： C07C209/26 ,  A01N37/42 ,  C07B43/04 ,  C07C211/29 ,  C07C249/04

摘要： Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Pt, Rh, Ir, and Ru, and in absence of any catalytic amount of any second metal from the list consisting of Ag, Ni, Co, Sn, Bi, Cu, Au, and combinations thereof. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of active agrochemical compounds and microbicides of the methoximinophenylglyoxylic ester series.

公开(公告)号：US10173961B2

公开(公告)日：2019-01-08

申请号：US15523864

申请日：2015-11-04

申请人： Taminco BVBA

发明人： Kristof Moonen ,  Kim Dumoleijn ,  Laura Prati ,  Alberto Villa

IPC分类号： A01N37/42 ,  C07B43/04 ,  C07C209/26 ,  C07C211/29 ,  C07C249/04

摘要： Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Pt, Rh, Ir, and Ru, and in absence of any catalytic amount of any second metal from the list consisting of Ag, Ni, Co, Sn, Bi, Cu, Au, and combinations thereof. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of active agrochemical compounds and microbicides of the methoximinophenylglyoxylic ester series.