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公开(公告)号：US08664213B2
公开(公告)日：2014-03-04
申请号：US13596211
申请日：2012-08-28
IPC分类号： A01N43/00 , A61K31/00 , A01N43/38 , A61K31/40 , C07D209/96 , C07D487/00 , C07D491/00 , C07D495/00 , C07D205/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group consisting of: are useful as HIV attachment inhibitors.
摘要翻译： 式I化合物，包括其药学上可接受的盐：其中A选自：可用作HIV附着抑制剂。
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2.发明申请SPIRO BICYCLIC DIAMINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS 有权作为艾滋病毒附着抑制剂的SPIRO BICYCLIC DIAMINE DERIVATIVES公开(公告)号：US20130231324A1
公开(公告)日：2013-09-05
申请号：US13596211
申请日：2012-08-28
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group consisting of: are useful as HIV attachment inhibitors.
摘要翻译： 式I化合物，包括其药学上可接受的盐：其中A选自：可用作HIV附着抑制剂。
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3.发明申请THIOAMIDE, AMIDOXIME AND AMIDRAZONE DERIVATIVES AS HIV ATTACHMENT INHIBITORS 有权作为艾滋病毒治疗抑制剂的噻托咪胺，阿米卡星和阿米卡星衍生物公开(公告)号：US20130102615A1
公开(公告)日：2013-04-25
申请号：US13444104
申请日：2012-04-11
IPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D403/06
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D209/12 , C07D209/18 , C07D403/06 , A61K2300/00
摘要： A compound of Formula I, including pharmaceutically acceptable salts thereof: wherein A is selected from the group of:
摘要翻译： 式I的化合物，包括其药学上可接受的盐：其中A选自：
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4.发明申请PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS 审中-公开替代酰基氨基哌啶衍生物与蛋白酶抑制剂的药物制剂公开(公告)号：US20120238583A1
公开(公告)日：2012-09-20
申请号：US13473683
申请日：2012-05-17
申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC分类号： A61K31/496 , A61P31/18
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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![Diketo substituted pyrrolo[2,3-c] pyridines](/abs-image/US/2011/06/14/US07960406B2/abs.jpg.150x150.jpg)
公开(公告)号：US07960406B2
公开(公告)日：2011-06-14
申请号：US12490714
申请日：2009-06-24
申请人： Tao Wang , Yasutsugu Ueda , Lawrence G. Hamann , Zhongxing Zhang , Zhiwei Yin , Alicia Regueiro-Ren , David J. Carini , Jacob Swidorski , Zheng Liu , Barry L. Johnson , Nicholas A. Meanwell , John F. Kadow
发明人： Tao Wang , Yasutsugu Ueda , Lawrence G. Hamann , Zhongxing Zhang , Zhiwei Yin , Alicia Regueiro-Ren , David J. Carini , Jacob Swidorski , Zheng Liu , Barry L. Johnson , Nicholas A. Meanwell , John F. Kadow
IPC分类号： A61K31/44
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives of Formula I: that possess unique antiviral activity are provided. These compounds are useful for the treatment of HIV and AIDS.
摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，提供具有独特抗病毒活性的二酮稠合偶氮哌啶和式I的偶氮哌嗪衍生物。 这些化合物可用于治疗艾滋病毒和艾滋病。
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6.发明申请公开(公告)号：US20110118279A1
公开(公告)日：2011-05-19
申请号：US13007194
申请日：2011-01-14
申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC分类号： A61K31/496 , A61P31/18
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
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公开(公告)号：US20090253741A1
公开(公告)日：2009-10-08
申请号：US12484407
申请日：2009-06-15
申请人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
发明人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
IPC分类号： A61K31/4709 , C07D401/12 , A61P31/18
CPC分类号： A61K31/445 , A61K31/4545 , A61K45/06 , C07D211/70 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14 , A61K2300/00
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译： 本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的烯烃哌啶衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。
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8.发明授权Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives 有权取代的氮杂脱氧乙酸哌嗪衍生物的组成和抗病毒活性公开(公告)号：US07354924B2
公开(公告)日：2008-04-08
申请号：US10969675
申请日：2004-10-20
申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC分类号： A61K31/496 , C07D487/02 , A61K31/497 , A61K31/501 , A61K31/506
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
摘要： This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. Compound I is wherein: Q is selected from the group consisting of: m is 1 or 2; —W— is A is selected from the group consisting of C1-6alkoxy, aryl and heteroaryl; in which said aryl is phenyl or napthyl; said heteroaryl is selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, triazinyl, furanyl, thienyl, pyrrolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, quinolinyl, isoquinolinyl, benzofuranyl, benzothienyl, benzoimidazolyl and benzothiazolyl; and said aryl or heteroaryl is optionally substituted with one or two of the same or different members selected from the group consisting of amino, nitro, cyano, hydroxy, C1-6alkoxy, —C(O)NH2; and C1-6alkyl, —NHC(O)CH3, halogen and trifluoromethyl.
摘要翻译： 本发明提供具有药物和生物影响性质的化合物I，其药物组合物和使用方法。 特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。 化合物I是其中：Q选自：m是1或2; -W-是A选自C 1-6烷氧基，芳基和杂芳基; 其中所述芳基是苯基或萘基; 吡啶基，吡嗪基，咪唑基，噻唑基，异噻唑基，恶唑基，异恶唑基，喹啉基，异喹啉基，苯并呋喃基，苯并噻吩基，苯并咪唑基和苯并噻唑基; 并且所述芳基或杂芳基任选被一个或两个相同或不同的选自氨基，硝基，氰基，羟基，C 1-6烷氧基，-C（O） NH 2; 和C 1-6烷基，-NHC（O）CH 3，卤素和三氟甲基。
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公开(公告)号：US20070249579A1
公开(公告)日：2007-10-25
申请号：US11733283
申请日：2007-04-10
申请人： Tao Wang , John F. Kadow , Zhongxing Zhang , Zhiwei Yin , Nicholas A. Meanwell , Alicia Regueiro-Ren , Jacob Swidorski , Ying Han , David J. Carini
发明人： Tao Wang , John F. Kadow , Zhongxing Zhang , Zhiwei Yin , Nicholas A. Meanwell , Alicia Regueiro-Ren , Jacob Swidorski , Ying Han , David J. Carini
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , C07D471/02
CPC分类号： C07D471/04 , C07D403/12 , C07D417/14
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with diketo piperazine and piperadine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译： 本公开提供了具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的二酮哌嗪和哌嗪衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。
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公开(公告)号：US08912195B2
公开(公告)日：2014-12-16
申请号：US13990815
申请日：2011-12-01
申请人： Tao Wang , Zhongxing Zhang , Zhiwei Yin , John F. Kadow , Nicholas A. Meanwell
发明人： Tao Wang , Zhongxing Zhang , Zhiwei Yin , John F. Kadow , Nicholas A. Meanwell
IPC分类号： A61K31/496 , C07D471/04 , C07D403/04
CPC分类号： C07D471/04
摘要： Compounds of Formula (I), including pharmaceutically acceptable salts thereof, wherein A is selected from the group (II), are useful as HIV attachment inhibitors.
摘要翻译： 式（I）化合物，包括其药学上可接受的盐，其中A选自（II）组，可用作HIV附着抑制剂。
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