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1.
公开(公告)号:US20120156193A1
公开(公告)日:2012-06-21
申请号:US13389228
申请日:2010-08-05
申请人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号: A61K39/395 , A61P25/28 , G01N33/566 , C07K16/18
CPC分类号: C07K16/18 , C07K2317/56 , C07K2317/565 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the anti-bodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译: 本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。 证明抗体可用作阿尔茨海默氏病的诊断/治疗单克隆抗体。
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2.
公开(公告)号:US20120082667A1
公开(公告)日:2012-04-05
申请号:US13264671
申请日:2010-04-16
申请人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
发明人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
IPC分类号: A61K39/395 , A61P25/00 , A61P25/28 , C07K16/18 , G01N33/566
CPC分类号: C07K16/18 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译: 本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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3.
公开(公告)号:US08858949B2
公开(公告)日:2014-10-14
申请号:US13389229
申请日:2010-08-05
申请人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号: A61K39/395 , G01N33/566 , G01N33/68 , C07K16/18
CPC分类号: G01N33/6896 , C07K16/18 , C07K2317/33 , G01N2800/2821
摘要: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译: 本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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4.
公开(公告)号:US08613924B2
公开(公告)日:2013-12-24
申请号:US13389228
申请日:2010-08-05
申请人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号: A61K39/395 , G01N33/53 , C07K16/18 , C12P21/08
CPC分类号: C07K16/18 , C07K2317/56 , C07K2317/565 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the anti-bodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译: 本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。 证明抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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5.
公开(公告)号:US09090679B2
公开(公告)日:2015-07-28
申请号:US13264671
申请日:2010-04-16
申请人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
发明人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
CPC分类号: C07K16/18 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译: 本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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6.
公开(公告)号:US20120177664A1
公开(公告)日:2012-07-12
申请号:US13389229
申请日:2010-08-05
申请人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人: Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号: A61K39/395 , A61P25/00 , A61P25/28 , C07K16/18 , G01N33/566
CPC分类号: G01N33/6896 , C07K16/18 , C07K2317/33 , G01N2800/2821
摘要: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译: 本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。 证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。
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