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1.发明授权公开(公告)号：US07985877B2
公开(公告)日：2011-07-26
申请号：US12301543
申请日：2007-05-31
IPC分类号： C07C59/135 , C07C41/18 , C07C41/22 , C07C43/12 , C07C51/09 , C07C51/367
CPC分类号： C07C41/18 , C07C41/22 , C07C51/09 , C07C51/367 , C07C67/31 , C07C43/12 , C07C69/708
摘要： The present invention provides a process for producing 1,1,1,3,3,3-hexafluoro-2-methoxypropane, wherein a novel compound, 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof is decarboxylated, or wherein an olefin compound represented by chemical formula (4): CF2═C(CF3)(OCH3) is reacted with a fluorinating agent; and a process for producing 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof by reacting a hydroxycarboxylic ester with a methylating agent and then hydrolyzing the reaction product, or hydrolyzing the hydroxycarboxylic ester and then reacting the resulting product with a methylating agent.In accordance with the invention, 1,1,1,3,3,3-hexafluoro-2-methoxypropane, which is useful as a raw material for, for example, the anesthetic Sevoflurane, can be produced efficiently and at low cost.
摘要翻译： 本发明提供一种生产1,1,1,3,3,3-六氟-2-甲氧基丙烷的方法，其中新化合物2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 或其中由化学式（4）表示的烯烃化合物：CF 2 = C（CF 3）（OCH 3）与氟化剂反应; 以及通过使羟基羧酸酯与甲基化剂反应然后水解反应产物或水解羟基羧酸酯，然后使所述羟基羧酸酯水解，从而使2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 得到的产物与甲基化剂。 根据本发明，作为例如麻醉剂七氟醚的原料可以使用的1,1,1,3,3,3-六氟-2-甲氧基丙烷可以有效且低成本地制造。
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2.发明申请NOVEL CARBOXYLIC ACID COMPOUND, USE THEREOF, AND PROCESS FOR PRODUCING THE SAME 有权新型羧酸化合物，其用途及其生产方法公开(公告)号：US20090156861A1
公开(公告)日：2009-06-18
申请号：US12301543
申请日：2007-05-31
IPC分类号： C07C59/135 , C07C43/12
CPC分类号： C07C41/18 , C07C41/22 , C07C51/09 , C07C51/367 , C07C67/31 , C07C43/12 , C07C69/708
摘要： The present invention provides a process for producing 1,1,1,3,3,3-hexafluoro-2-methoxypropane, wherein a novel compound, 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof is decarboxylated, or wherein an olefin compound represented by chemical formula (4): CF2═C(CF3)(OCH3) is reacted with a fluorinating agent; and a process for producing 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof by reacting a hydroxycarboxylic ester with a methylating agent and then hydrolyzing the reaction product, or hydrolyzing the hydroxycarboxylic ester and then reacting the resulting product with a methylating agent.In accordance with the invention, 1,1,1,3,3,3-hexafluoro-2-methoxypropane, which is useful as a raw material for, for example, the anesthetic Sevoflurane, can be produced efficiently and at low cost.
摘要翻译： 本发明提供一种生产1,1,1,3,3,3-六氟-2-甲氧基丙烷的方法，其中新化合物2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 或其中由化学式（4）表示的烯烃化合物：CF 2 -C（CF 3）（OCH 3）与氟化剂反应; 以及通过使羟基羧酸酯与甲基化剂反应然后水解反应产物或水解羟基羧酸酯，然后使所述羟基羧酸酯水解，从而使2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 得到的产物与甲基化剂。 根据本发明，作为例如麻醉剂七氟醚的原料可以使用的1,1,1,3,3,3-六氟-2-甲氧基丙烷可以有效且低成本地制造。
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公开(公告)号：US07598425B2
公开(公告)日：2009-10-06
申请号：US11578523
申请日：2005-04-08
IPC分类号： C07C29/48
CPC分类号： C07C29/48 , C07C29/00 , C07C45/30 , C07C31/42 , C07C49/167
摘要： The present invention relates to a method for producing a compound represented by formula (2): [CF3(CF2)n][CF3(CF2)m]C(OH)2 (2) wherein n and m independently represent 0 to 10, the method comprising reacting with a halogen or a halogen-containing oxidizing agent a salt of a compound represented by formula (1): [CF3(CF2)n][CF3(CF2)m]C(OH)COOH (1) wherein n and m independently represent 0 to 10.
摘要翻译： 本发明涉及一种制备式（2）表示的化合物的方法：<？in-line-formula description =“In-line formula”end =“lead”？> [CF3（CF2）n] [CF3（ CF 2）m] C（OH）2（2）<？在线公式描述=“在线公式”end =“tail”？>其中n和m独立地表示0至10，该方法包括与 卤素或含卤素的氧化剂，由式（1）表示的化合物的盐：<？in-line-formula description =“In-line formula”end =“lead”？> [CF3（CF2）n] [ CF 3（CF 2）m] C（OH）COOH（1）<？在线公式描述=“内联式”末端=“尾”→其中n和m独立地表示0至10。
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公开(公告)号：US20080262273A1
公开(公告)日：2008-10-23
申请号：US11578523
申请日：2005-04-08
IPC分类号： C07C31/38
CPC分类号： C07C29/48 , C07C29/00 , C07C45/30 , C07C31/42 , C07C49/167
摘要： The present invention relates to a method for producing a compound represented by formula (2): [CF3(CF2)n][CF3(CF2)m]C(OH)2 (2) wherein n and m independently represent 0 to 10, the method comprising reacting with a halogen or a halogen-containing oxidizing agent a salt of a compound represented by formula (1): [CF3(CF2)n][CF3(CF2)m]C(OH)COOH (1) wherein n and m independently represent 0 to 10.
摘要翻译： 本发明涉及一种制备式（2）表示的化合物的方法：<？in-line-formula description =“In-line formula”end =“lead”？> [CF 3 （CF 2）n [CF 3]（CF 2 2）m] C（OH）2（2）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中n和m独立地表示0至10，该方法包括 与卤素或含卤素的氧化剂与式（1）表示的化合物的盐反应：<？in-line-formula description =“In-line formula”end =“lead”？> [CF （CF 2）2（CF 2）n（CF 2）n（CF 2） C（OH）COOH（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中n和m独立地表示0至10。
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5.发明授权Alpha-fluoromethoxycarboxylic ester, process for producing the alpha-fluoromethoxycarboxylic ester, and process for producing sevoflurane 有权α-氟甲氧基羧酸酯，α-氟甲氧基羧酸酯的制造方法，七氟醚的制造方法公开(公告)号：US08022245B2
公开(公告)日：2011-09-20
申请号：US12305467
申请日：2007-06-27
CPC分类号： C07C41/18 , C07C67/31 , C07C69/708 , C07C43/123
摘要： The present invention provides a novel α-fluoromethoxycarboxylic ester represented by Formula (1): (CF3)2C(OCH2F)COOR wherein R is a hydrocarbon group that may have a substituent; a process for producing 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether, the process including hydrolyzing and decarboxylating the α-fluoromethoxycarboxylic ester; and a process for producing an α-fluoromethoxycarboxylic ester represented by Formula (1): (CF3)2C (OCH2F)COOR, the process including reacting an α-hydroxycarboxylic ester represented by Formula (2): (CF3)2C(OH)COOR with a halofluoromethane in the presence of an alkaline compound. According to the present invention, 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether (sevoflurane), which is known as an anesthetic compound, can be efficiently produced at low cost.
摘要翻译： 本发明提供由式（1）表示的新型α-氟甲氧基羧酸酯：（CF 3）2 C（OCH 2 F）COOR其中R为可具有取代基的烃基; 一种生产1,1,1,3,3,3-六氟异丙基氟甲基醚的方法，该方法包括水解和脱羧α-氟甲氧基羧酸酯; （CF3）2C（OCH2F）COOR表示的α-羟甲基羧酸酯的制造方法，包括使式（2）表示的α-羟基羧酸酯：（CF 3）2 C（OH）COOR 在一种碱性化合物存在下用卤代氟甲烷。 根据本发明，可以以低成本有效地制造作为麻醉剂化合物的1,1,1,3,3,3-六氟异丙基氟甲基醚（七氟醚）。
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6.发明申请NOVEL ALPHA-FLUOROMETHOXYCARBOXYLIC ESTER, PROCESS FOR PRODUCING THE ALPHA-FLUOROMETHOXYCARBOXYLIC ESTER, AND PROCESS FOR PRODUCING SEVOFLURANE 有权新型ALPHA-氟甲氧基羧酸酯，生产ALPHA-氟甲氧基羧酸酯的方法和生产七氟醚的方法公开(公告)号：US20100010255A1
公开(公告)日：2010-01-14
申请号：US12305467
申请日：2007-06-27
IPC分类号： C07C69/67 , C07C59/135 , C07C41/01 , C07C67/307
CPC分类号： C07C41/18 , C07C67/31 , C07C69/708 , C07C43/123
摘要： The present invention provides a novel α-fluoromethoxycarboxylic ester represented by Formula (1): (CF3)2C(OCH2F)COOR wherein R is a hydrocarbon group that may have a substituent; a process for producing 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether, the process including hydrolyzing and decarboxylating the α-fluoromethoxycarboxylic ester; and a process for producing an α-fluoromethoxycarboxylic ester represented by Formula (1): (CF3)2C (OCH2F)COOR, the process including reacting an α-hydroxycarboxylic ester represented by Formula (2): (CF3)2C(OH)COOR with a halofluoromethane in the presence of an alkaline compound. According to the present invention, 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether (sevoflurane), which is known as an anesthetic compound, can be efficiently produced at low cost.
摘要翻译： 本发明提供由式（1）表示的新型α-氟甲氧基羧酸酯：（CF 3）2 C（OCH 2 F）COOR，其中R为可具有取代基的烃基; 制备1,1,1,3,3,3-六氟异丙基氟甲醚的方法，该方法包括水解和脱羧α-氟甲氧基羧酸酯; 和由式（1）表示的α-氟甲氧基羧酸酯的方法：（CF 3）2 C（OCH 2 F）COOR，该方法包括使由式（2）表示的α-羟基羧酸酯：（CF 3）2 C（OH）COOR 在一种碱性化合物存在下用卤代氟甲烷。 根据本发明，可以以低成本有效地制造作为麻醉剂化合物的1,1,1,3,3,3-六氟异丙基氟甲基醚（七氟醚）。
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公开(公告)号：US07005545B2
公开(公告)日：2006-02-28
申请号：US10515338
申请日：2003-05-23
IPC分类号： C07C309/00
CPC分类号： C07C303/22 , C07C309/82
摘要： The present invention provides a process for producing a fluorinated fluorosulfonylalkyl vinyl ether represented by general formula (2): CF2═CFO(CF2CF(CF3)O)nCF2CF2SO2F (2) wherein n is an integer from 0 to 10, comprising fluorinating a perfluorovinylether sulfonate with SF4 and HF, the perfluorovinylether sulfonate being represented by general formula (1): CF2═CFO(CF2CF(CF3)O)nCF2CF2SO3M (1) wherein M is Ma or Mb1/2, provided that Ma is an alkali metal and Mb is an alkaline earth metal; and n is as defined above. According to the process of the invention, the fluorinated fluorosulfonylalkyl vinyl ether can be produced in high yield in an industrially advantageous manner.
摘要翻译： 本发明提供一种由通式表示的氟化氟磺酰基烷基乙烯基醚的制备方法
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公开(公告)号：US20050177001A1
公开(公告)日：2005-08-11
申请号：US10515338
申请日：2003-05-23
IPC分类号： C07C303/22 , C07C309/82 , C07C39/82
CPC分类号： C07C303/22 , C07C309/82
摘要： The present invention provides a process for producing a fluorinated fluorosulfonylalkyl vinyl ether represented by general formula (2): CF2=CFO(CF2CF(CF3)O)nCF2CF2SO2F (2) wherein n is an integer from 0 to 10, comprising fluorinating a perfluorovinylether sulfonate with SF4 and HF, the perfluorovinylether sulfonate being represented by general formula (1): CF2=CFO(CF2CF(CF3)O)nCF2CF2SO3M (1) wherein M is Ma or Mb1/2, provided that Ma is an alkali metal and Mb is an alkaline earth metal; and n is as defined above. According to the process of the invention, the fluorinated fluorosulfonylalkyl vinyl ether can be produced in high yield in an industrially advantageous manner.
摘要翻译： 本发明提供一种制备由通式（2）表示的氟化氟磺酰基烷基乙烯基醚的方法：<？in-line-formula description =“In-line formula”end =“lead”？> CF 2 SUB> = CFO（CF 2 CF（CF 3 O）O）2 CF 2 CF 2 其中n为0至10的整数，包括：（1）（式中，n为0〜10的整数， 氟化全氟乙烯基醚磺酸盐与SF 4和HF氟化，全氟乙烯基醚磺酸盐由通式（1）表示：<？in-line-formula description =“In-line Formulas”end =“lead”？ CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 2 CF 3 （1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中M是 Ma或Mb <1/2>，条件是Ma是碱金属，Mb是碱土金属; 和n如上所定义。 根据本发明的方法，氟化氟磺酰基烷基乙烯基醚可以以工业上有利的方式以高产率制备。
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公开(公告)号：US08013182B2
公开(公告)日：2011-09-06
申请号：US12734606
申请日：2008-11-06
CPC分类号： C07C69/708 , C07C41/18 , C07C67/307 , C07C43/123
摘要： The present invention provides a process for producing a novel compound, i.e., α-chloromethoxycarboxylic acid ester represented by General Formula (1): (CF3)2C(OCH2Cl)COOR, wherein R is a hydrocarbon group which may be substituted with at least one atom selected from the group consisting of halogen, oxygen, nitrogen, and sulfur atoms, comprising reacting an α-methoxycarboxylic acid ester represented by General Formula (2): (CF3)2C(OCH3)COOR, wherein R is as defined above, with molecular chlorine; and a process for producing 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether represented by a chemical formula (CF3)2CH(OCH2F), comprising fluorinating and decarboxylating the α-chloromethoxycarboxylic acid ester.According to the present invention, 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether (sevoflurane), which is known as a compound having an anesthetic property, can be produced efficiently and at a low cost.
摘要翻译： 本发明提供一种新型化合物的制备方法，即由通式（1）表示的α-氯甲氧基羧酸酯：（CF 3）2 C（OCH 2 Cl）COOR，其中R为可被至少一个 包括将由通式（2）表示的α-甲氧基羧酸酯：（CF 3）2 C（OCH 3）COOR（其中R如上所定义）与由卤素，氧，氮和硫原子组成的组中的原子与 分子氯; 以及由化学式（CF 3）2 CH（OCH 2 F）表示的1,1,1,3,3,3-六氟异丙基氟甲基醚的制备方法，其包括使α-氯甲氧基羧酸酯氟化和脱羧。 根据本发明，可以有效且低成本地制备作为具有麻醉性的化合物的1,1,1,3,3,3-六氟异丙基氟甲基醚（七氟烷）。
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10.发明申请公开(公告)号：US20100234634A1
公开(公告)日：2010-09-16
申请号：US12734606
申请日：2008-11-06
CPC分类号： C07C69/708 , C07C41/18 , C07C67/307 , C07C43/123
摘要： The present invention provides a process for producing a novel compound, i.e., α-chloromethoxycarboxylic acid ester represented by General Formula (1): (CF3)2C(OCH2Cl)COOR, wherein R is a hydrocarbon group which may be substituted with at least one atom selected from the group consisting of halogen, oxygen, nitrogen, and sulfur atoms, comprising reacting an α-methoxycarboxylic acid ester represented by General Formula (2): (CF3)2C(OCH3)COOR, wherein R is as defined above, with molecular chlorine; and a process for producing 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether represented by a chemical formula (CF3)2CH(OCH2F), comprising fluorinating and decarboxylating the α-chloromethoxycarboxylic acid ester.According to the present invention, 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether (sevoflurane), which is known as a compound having an anesthetic property, can be produced efficiently and at a low cost.
摘要翻译： 本发明提供一种新型化合物的制备方法，即由通式（1）表示的α-氯甲氧基羧酸酯：（CF 3）2 C（OCH 2 Cl）COOR，其中R为可被至少一个 包括将由通式（2）表示的α-甲氧基羧酸酯：（CF 3）2 C（OCH 3）COOR（其中R如上所定义）与由卤素，氧，氮和硫原子组成的组中的原子与 分子氯; 以及由化学式（CF 3）2 CH（OCH 2 F）表示的1,1,1,3,3,3-六氟异丙基氟甲基醚的制备方法，其包括使α-氯甲氧基羧酸酯氟化和脱羧。 根据本发明，可以有效且低成本地制备作为具有麻醉性的化合物的1,1,1,3,3,3-六氟异丙基氟甲基醚（七氟烷）。
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