公开(公告)号：US20170290842A1

公开(公告)日：2017-10-12

申请号：US15626198

申请日：2017-06-19

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Anat ACHIRON ,  Roi MASHIACH ,  Michael GUREVICH

IPC: A61K31/551

CPC classification number: A61K31/551 ,  C07D513/14 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02A50/414

Abstract: Provided are novel compounds which are capable of inhibiting an activity of RNA polymerase I, and uses thereof in treating diseases or disorders modulated by RNA polymerase I, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.

公开(公告)号：US20150315646A1

公开(公告)日：2015-11-05

申请号：US14703942

申请日：2015-05-05

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Anat ACHIRON ,  Michael GUREVICH

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/166

Abstract: Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency.

Abstract translation: 提供了用于将受试者分类为更可能具有良性多发性硬化（BMS）或更可能具有典型的复发性多发性硬化症（RRMS）的方法和试剂盒。 通过将受试者细胞中涉及的RNA聚合酶I途径中的至少一个基因的表达水平与从至少一个细胞获得的所述至少一种基因的参考表达数据进行比较来进行多发性硬化症病程的分类 一个被预先诊断为患有BMS的受试者和/或来自预先诊断为具有典型RRMS的至少一个受试者的细胞，从而将受试者分类为更可能具有BMS或更可能具有典型的RRMS。 还提供诊断和治疗多发性硬化症的方法以及监测治疗效率的方法。

公开(公告)号：US20170362657A1

公开(公告)日：2017-12-21

申请号：US15626229

申请日：2017-06-19

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Anat ACHIRON ,  Michael GUREVICH

IPC: C12Q1/68

Abstract: Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency.

公开(公告)号：US20160032393A1

公开(公告)日：2016-02-04

申请号：US14882580

申请日：2015-10-14

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Anat ACHIRON ,  Michael GUREVICH

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Provided are methods and kits for predicting the prognosis of a subject diagnosed with multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with multiple sclerosis and having good or poor clinical outcome. Also provided are methods and kits for selecting a treatment regimen of a subject diagnosed with multiple sclerosis.

Abstract translation: 提供了通过确定被诊断患有多发性硬化并且具有良好或差的临床结果的受试者之间差异表达的多核苷酸的表达水平来预测诊断为多发性硬化症的受试者的预后的方法和试剂盒。 还提供了用于选择诊断为多发性硬化症的受试者的治疗方案的方法和试剂盒。