公开(公告)号：US20230234943A1

公开(公告)日：2023-07-27

申请号：US18002557

申请日：2021-06-25

Applicant: Tempest Therapeutics, Inc.

Inventor： Thomas Walter DUBENSKY, JR. ,  Ryan C. CLARK ,  Justin ERNST ,  Garrick K. PACKARD ,  Brett BUSCH ,  Joe Fred NAGAMIZO ,  Biswajit KALITA ,  Athisayamani Jeyaraj DURAISWAMY

IPC: C07D405/04 ,  C07D471/04 ,  C07D235/18 ,  C07D277/66 ,  C07D487/04 ,  C07D495/04 ,  C07D473/00 ,  C07D513/04 ,  C07D473/32 ,  C07D403/12 ,  C07D403/04 ,  C07D401/12 ,  C07D401/04 ,  C07D487/10 ,  C07F7/08 ,  C07D487/08 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07D405/04 ,  C07D471/04 ,  C07D235/18 ,  C07D277/66 ,  C07D487/04 ,  C07D495/04 ,  C07D473/00 ,  C07D513/04 ,  C07D473/32 ,  C07D403/12 ,  C07D403/04 ,  C07D401/12 ,  C07D401/04 ,  C07D487/10 ,  C07F7/0812 ,  C07D487/08 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098

Abstract: Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds for inhibiting three prime repair exonuclease 1 (“TREX1”).