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    Antifungal 4-substituted 5,6-dihydro-4H-pyrrolo [1,2-a][1,4]benzodiazepines
    1.
    发明授权
    Antifungal 4-substituted 5,6-dihydro-4H-pyrrolo [1,2-a][1,4]benzodiazepines 有权
    抗真菌4-取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂卓

    公开(公告)号：US07820650B2

    公开(公告)日：2010-10-26

    申请号：US11680700

    申请日：2007-03-01

    申请人： Terence Gilkerson ,  Roger John Nash ,  Jozef Frans Elisabetha Van Gestel ,  Lieven Meerpoel

    发明人： Terence Gilkerson ,  Roger John Nash ,  Jozef Frans Elisabetha Van Gestel ,  Lieven Meerpoel

    IPC分类号： A61P31/10 ,  A61K31/55 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/55 ,  A61K31/551

    摘要： The present invention concerns compounds for use as a medicine having the formula the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 represents hydrogen, C1-6alkyl, C1-4alkylthio, C1-4alkyloxy, or halo; R2 represents hydrogen or C1-6alkyl; R3 represents phenyl substituted with halo, cyano, C1-4alkyloxy, C1-4alkylthio, C1-6alkyl, haloC1-6alkyl; 2-thienyl; or 3-thienyl, R4 represents hydrogen; or R2 and R4 form an extra bond, which are active against dermatophytes, and their preparation; it further relates to compositions comprising them, as well as their use as a medicine.

    摘要翻译： 本发明涉及用作具有N-氧化物形式的药物的化合物，其盐，季胺和立体化学异构形式，其中R 1表示氢，C 1-6烷基，C 1-4烷硫基，C 1-4烷氧基或卤素 ; R 2表示氢或C 1-6烷基; R 3表示被卤素，氰基，C 1-4烷氧基，C 1-4烷硫基，C 1-6烷基，卤代C 1-6烷基取代的苯基; 2-噻吩基; 或3-噻吩基，R 4表示氢; 或R2和R4形成额外的键，其对皮肤癣菌有活性，并且它们的制备; 它还涉及包含它们的组合物以及它们作为药物的用途。

    Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines
    2.
    发明授权
    Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines 有权
    抗真菌剂4-取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂卓

    公开(公告)号：US07202240B2

    公开(公告)日：2007-04-10

    申请号：US10399596

    申请日：2001-10-17

    申请人： Terence Gilkerson ,  Roger John Nash ,  Jozel Frans Elisabetha Van Gestel ,  Lieven Meerpoel

    发明人： Terence Gilkerson ,  Roger John Nash ,  Jozel Frans Elisabetha Van Gestel ,  Lieven Meerpoel

    IPC分类号： A61K31/55 ,  A61P31/10 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/55 ,  A61K31/551

    摘要： The present invention concerns compounds for use as a medicine having the formula (I), the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 represents hydrogen, C1-6 alkyl, C1-4alkylthio, C1-4alkyloxy, or halo; R2 represents hydrogen or C1-6alkyl; R3 represents phenyl substituted with halo, cyano, C1-4alkyloxy, C1-4alkylthio, C1-6alkyl, haloC1-6alkyl; 2-thienyl; or 3-thienyl, R4 represents hydrogen; or R2 and R4 form an extra bond, which are active against dermatophytes, and their preparation; it further relates to compositions comprising them, as well as their use as a medicine.

    摘要翻译： 本发明涉及用作具有式（I）的药物，N-氧化物形式，其盐，季胺及其立体化学异构形式的化合物，其中R 1表示氢， C 1-4烷基，C 1-4烷基硫基，C 1-4烷基氧基或卤素; R 2表示氢或C 1-6烷基; R 3表示被卤素，氰基，C 1-4烷氧基，C 1-4烷基硫基，C 1-6烷基取代的苯基 烷基，卤代C 1-6烷基; 2-噻吩基; 或3-噻吩基，R 4表示氢; 或R 2和R 4形成对皮肤癣菌有活性的额外的结合，及其制备; 它还涉及包含它们的组合物以及它们作为药物的用途。