公开(公告)号：US20080318225A1

公开(公告)日：2008-12-25

申请号：US11840112

申请日：2007-08-16

申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/535

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。

公开(公告)号：US09315867B2

公开(公告)日：2016-04-19

申请号：US12939801

申请日：2010-11-04

申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。

公开(公告)号：US07851144B2

公开(公告)日：2010-12-14

申请号：US11840112

申请日：2007-08-16

申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

IPC分类号： C12Q1/00 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。

公开(公告)号：US20110104694A1

公开(公告)日：2011-05-05

申请号：US12939801

申请日：2010-11-04

申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。