公开(公告)号：US5160742A

公开(公告)日：1992-11-03

申请号：US816412

申请日：1991-12-31

申请人： Terrence B. Mazer ,  Glenn A. Meyer ,  Shie-Ming Hwang ,  Edrick L. Candler, Jr. ,  Lonnie R. Drayer ,  Andre Daab-Krzykowski

发明人： Terrence B. Mazer ,  Glenn A. Meyer ,  Shie-Ming Hwang ,  Edrick L. Candler, Jr. ,  Lonnie R. Drayer ,  Andre Daab-Krzykowski

IPC分类号： A61K9/22 ,  A61K9/50 ,  A61K9/58 ,  A61K9/64

CPC分类号： A61K9/5073 ,  A61K9/5052

摘要： A system for delivering an active substance has sustained release of the active substance in the intestinal tract. This delivery system is especially useful for an active substance such as a .beta.-lactam antibiotic which preferably has minimal exposure to the acidic environment of the stomach. Particles comprise an active ingredient disposed in a core which has at least one coating of a prolamine and one coating of an enteric compound thereon. The particles may be very small and suspended in a liquid medium.

摘要翻译： 用于递送活性物质的系统使活性物质在肠道中持续释放。 该递送系统对于活性物质如β-内酰胺抗生素特别有用，β-内酰胺抗生素优选最少暴露于胃的酸性环境。 颗粒包含配置在核心中的活性成分，其中至少有一层谷醇溶胶和一种肠溶化合物涂层。 颗粒可能非常小并悬浮在液体介质中。