公开(公告)号：US5989556A

公开(公告)日：1999-11-23

申请号：US890065

申请日：1997-07-09

申请人： Hsiu-Hsien Tsai ,  Shie-Ming Hwang

发明人： Hsiu-Hsien Tsai ,  Shie-Ming Hwang

IPC分类号： A61K36/00 ,  A61K9/20 ,  A61K9/48 ,  A61K36/28 ,  A61K36/48 ,  A61K36/539 ,  A61K36/638 ,  A61K36/81 ,  A61P31/12 ,  A61P31/18 ,  A61K35/78

CPC分类号： A61K36/00 ,  A61K36/28 ,  A61K36/48 ,  A61K36/638 ,  A61K36/81 ,  A61K9/20 ,  A61K9/48 ,  Y10S514/885 ,  Y10S514/894 ,  Y10S514/895

摘要： Compositions derived from Chinese herbal medicines, medicinal plants and extracts thereof, are provided for the treatment of animals infected with viruses, especially with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). More specifically, the compositions of the present invention are derived from various Chinese herbal medicines or medicinal plants which have a long history of human consumption. The compositions of the invention are obtained through specific techniques and have demonstrated outstanding efficacy for treating human HBV carriers and hepatitis C patients. Compositions according to the invention have also exhibited in vitro antiviral activities against murine leukemia virus (MuLV) and HIV. HIV is the virus known to cause acquired immunodeficiency syndrome (AIDS) in humans and AIDS presents special problems to the medical community which the present invention addresses. Preferred compositions contain the herbal ingredients AEGINETIAE HERBA, BLECHNI RHIZOMA, LESPEDEZAE HERBA, POLYGONI CUSPIDATI RHIZOMA, FORSYTHIAE FRUCTUS, and LIGUSTRI FRUCTUS, or contain the herbal ingredients AEGINETIAE HERBA, LONICERAE FLOS, PRUNELLAE SPICA, and LESPEDEZAE HERBA.

摘要翻译： 提供中草药成分，药用植物及其提取物，用于治疗感染病毒的动物，特别是乙型肝炎病毒（HBV），丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）。 更具体地说，本发明的组合物衍生自具有长期人类消费历史的各种中草药或药用植物。 通过具体技术获得本发明的组合物，并且已经证明了治疗人HBV携带者和丙型肝炎患者的突出功效。 根据本发明的组合物还显示针对鼠白血病病毒（MuLV）和HIV的体外抗病毒活性。 艾滋病毒是已知会导致人类获得性免疫缺陷综合征（AIDS）的病毒，艾滋病对本发明所涉及的医疗社区具有特殊问题。 优选的组合物含有草药成分AEGINETIAE HERBA，BLECHNI RHIZOMA，LESPEDEZAE HERBA，POLYGONI CUSPIDATI RHIZOMA，FORSYTHIAE FRUCTUS和LIGUSTRI FRUCTUS，或含有草药成分AEGINETIAE HERBA，LONICERAE FLOS，PRUNELLAE SPICA和LESPEDEZAE HERBA。

公开(公告)号：US06447797B2

公开(公告)日：2002-09-10

申请号：US09838351

申请日：2001-04-19

申请人： Shie-Ming Hwang ,  Yung-Sheng Huang ,  Jim-Wen Liu ,  Pradip Mukerji ,  Steven Neal Anderson ,  Jonathan A. Meulbroek

发明人： Shie-Ming Hwang ,  Yung-Sheng Huang ,  Jim-Wen Liu ,  Pradip Mukerji ,  Steven Neal Anderson ,  Jonathan A. Meulbroek

IPC分类号： A61K920

CPC分类号： A23L33/10 ,  Y10S514/888

摘要： It has been discovered that certain phosphoinositides demonstrate antibacterial activity. Particularly, these phosphoinositides have been discovered to prevent the adhesion of H. influenzae onto the nasopharyngeal cells of mammals, and, in particular, humans. Phosphoinositides useful with the present invention have the following formula: wherein R1 and R2 are selected from the group consisting of hydrogen and monounsaturated and saturated fatty acids having a carbon chain length of C6 to C20 and R1 and R2 can be the same or different; and R3 to R7 are selected from the group consisting of hydrogen or a phosphate moiety with at least two of R3 to R7 being a phosphate moiety; and hydrates and pharmaceutically acceptable salts thereof.

摘要翻译： 已经发现某些磷酸肌醇表现出抗菌活性。 特别地，这些磷酸肌醇已被发现以防止流感嗜血杆菌粘附到哺乳动物，特别是人的鼻咽细胞上。 适用于本发明的磷酸肌醇具有下式：其中R 1和R 2选自氢和单链不饱和和碳原子数为C6〜C20的饱和脂肪酸，R1和R2可以相同或不同; 并且R 3至R 7选自氢或磷酸酯部分，其中至少两个R 3至R 7为磷酸酯部分; 及其水合物及其药学上可接受的盐。

公开(公告)号：US06214350B1

公开(公告)日：2001-04-10

申请号：US09376701

申请日：1999-08-17

申请人： Shie-Ming Hwang

发明人： Shie-Ming Hwang

IPC分类号： A61K3578

CPC分类号： A61K36/00 ,  A61K9/20 ,  A61K9/48 ,  A61K36/28 ,  A61K36/48 ,  A61K36/638 ,  A61K36/81 ,  Y10S514/885 ,  Y10S514/894 ,  Y10S514/895 ,  A61K2300/00

摘要： This invention relates to compositions derived from Chinese herbal medicines, medicinal plants and extracts thereof, and to their use for the treatment of animals infected with viruses, especially with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). More specifically, the compositions of the present invention arc derived from various Chinese herbal medicines or medicinal plants which have a long history of human consumption. The compositions of the invention are obtained through specific techniques and have demonstrated outstanding efficacy for treating human HBV carriers and hepatitis C patients. Compositions according to the invention have also exhibited in vitro antiviral activities against murine leukemia virus (MuLV) and HIV. HIV is the virus known to cause acquired immunodeficiency syndrome (AIDS) in humans and AIDS presents special problems to the medical community which the present invention addresses.

摘要翻译： 本发明涉及中草药衍生物，药用植物及其提取物，以及用于治疗感染病毒，特别是乙型肝炎病毒（HBV），丙型肝炎病毒（HCV）和人类免疫缺陷病毒 （HIV）。 更具体地说，本发明的组合物来自具有悠久的人类消费历史的各种中草药或药用植物。 通过具体技术获得本发明的组合物，并且已经证明了治疗人HBV携带者和丙型肝炎患者的突出功效。 根据本发明的组合物还显示针对鼠白血病病毒（MuLV）和HIV的体外抗病毒活性。 艾滋病毒是已知会导致人类获得性免疫缺陷综合征（AIDS）的病毒，艾滋病对本发明所涉及的医疗社区具有特殊问题。

公开(公告)号：US06258375B1

公开(公告)日：2001-07-10

申请号：US09035602

申请日：1998-03-05

申请人： Shie-Ming Hwang ,  Yung-Sheng Huang ,  Jim-Wen Liu ,  Pradip Mukerji ,  Steven Neal Anderson ,  Jonathan A. Meulbroek

发明人： Shie-Ming Hwang ,  Yung-Sheng Huang ,  Jim-Wen Liu ,  Pradip Mukerji ,  Steven Neal Anderson ,  Jonathan A. Meulbroek

IPC分类号： A61K900

CPC分类号： A23L33/10 ,  Y10S514/888

摘要： It has been discovered that certain phosphoinositides demonstrate antibacterial activity. Particularly, these phosphoinositides have been discovered to prevent the adhesion of H. influenzae onto the nasopharyngeal cells of mammals, and, in particular, humans. Phosphoinositides useful with the present invention have the following formula: wherein R1 and R2 are selected from the group consisting of hydrogen and monounsaturated and saturated fatty acids having a carbon chain length of C6 to C20 and R1 and R2 can be the same or different; and R3 to R7 are selected from the group consisting of hydrogen or a phosphate moiety with at least two of R3 to R7 being a phosphate moiety; and hydrates and pharmaceutically acceptable salts thereof.

摘要翻译： 已经发现某些磷酸肌醇表现出抗菌活性。 特别地，这些磷酸肌醇已被发现以防止流感嗜血杆菌粘附到哺乳动物，特别是人的鼻咽细胞上。 适用于本发明的磷酸肌醇具有下式：其中R 1和R 2选自氢和单链不饱和和碳原子数为C6〜C20的饱和脂肪酸，R1和R2可以相同或不同; 并且R 3至R 7选自氢或磷酸酯部分，其中至少两个R 3至R 7为磷酸酯部分; 及其水合物及其药学上可接受的盐。

公开(公告)号：US5776462A

公开(公告)日：1998-07-07

申请号：US761321

申请日：1996-12-10

申请人： Hsiu-Hsien Tsai ,  Shie-Ming Hwang

发明人： Hsiu-Hsien Tsai ,  Shie-Ming Hwang

IPC分类号： A61K9/20 ,  A61K9/68 ,  A61K36/53 ,  A61K36/532 ,  A61K47/00 ,  A61P11/04 ,  A61P31/04 ,  A61K35/78

CPC分类号： A61K36/53 ,  A61K36/532 ,  Y10S514/888

摘要： The attachment of H. influenzae to human cells such as oropharyngeal cells, is inhibited by aqueous extracts of the plants known as Pogostemon cablin and Agastache rugosa. The composition obtained from the aqueous extraction of the plants Pogostemon cablin, Agastache rugosa or mixtures thereof is also effective in preventing or treating Otitis media and sore throat. The plant extract may be contained in a liquid enteral product such as an infant formula or may be incorporated into lozenges, candies, chewing gums and the like. The plant extract may also be administered as a throat spray or nasally using drops or a spray. A process for the production of a medicinal product is also disclosed.

摘要翻译： 流感嗜血杆菌对人细胞如口咽细胞的附着被称为Pogostemon cablin和Agastache rugosa的植物的水提取物抑制。 从植物Pogostemon cablin，藿香或其混合物的水提取物获得的组合物也可有效预防或治疗中耳炎和喉咙痛。 植物提取物可以包含在液体肠内产品如婴儿配方奶粉中，或者可以掺入锭剂，糖果，口香糖等中。 植物提取物也可以使用滴剂或喷雾剂作为咽喉喷雾剂或鼻腔给药。 还公开了用于生产药用产品的方法。

公开(公告)号：US5160742A

公开(公告)日：1992-11-03

申请号：US816412

申请日：1991-12-31

申请人： Terrence B. Mazer ,  Glenn A. Meyer ,  Shie-Ming Hwang ,  Edrick L. Candler, Jr. ,  Lonnie R. Drayer ,  Andre Daab-Krzykowski

发明人： Terrence B. Mazer ,  Glenn A. Meyer ,  Shie-Ming Hwang ,  Edrick L. Candler, Jr. ,  Lonnie R. Drayer ,  Andre Daab-Krzykowski

IPC分类号： A61K9/22 ,  A61K9/50 ,  A61K9/58 ,  A61K9/64

CPC分类号： A61K9/5073 ,  A61K9/5052

摘要： A system for delivering an active substance has sustained release of the active substance in the intestinal tract. This delivery system is especially useful for an active substance such as a .beta.-lactam antibiotic which preferably has minimal exposure to the acidic environment of the stomach. Particles comprise an active ingredient disposed in a core which has at least one coating of a prolamine and one coating of an enteric compound thereon. The particles may be very small and suspended in a liquid medium.

摘要翻译： 用于递送活性物质的系统使活性物质在肠道中持续释放。 该递送系统对于活性物质如β-内酰胺抗生素特别有用，β-内酰胺抗生素优选最少暴露于胃的酸性环境。 颗粒包含配置在核心中的活性成分，其中至少有一层谷醇溶胶和一种肠溶化合物涂层。 颗粒可能非常小并悬浮在液体介质中。

公开(公告)号：US06248372B1

公开(公告)日：2001-06-19

申请号：US09428076

申请日：1999-10-27

申请人： Pradip Mukerji ,  Shie-Ming Hwang ,  Yung-Sheng Huang ,  Jim-Wen Liu ,  Steven Neal Anderson ,  Jonathan A. Meulbroek

发明人： Pradip Mukerji ,  Shie-Ming Hwang ,  Yung-Sheng Huang ,  Jim-Wen Liu ,  Steven Neal Anderson ,  Jonathan A. Meulbroek

IPC分类号： A61K3578

CPC分类号： A61K36/899

摘要： The present invention is directed to a rice flour extract (RFE) which can be used in the prophylaxis and treatment of bacterial infections, particularly bacterial infections caused by Haemophilus influenzae and to a method of preparing and using such an antibacterial rice flour extract. The anti-Haemophilus influenzae rice flour extract of the present invention can be prepared from commercial food grade rice flours or non-commercial food grade rice flours.

摘要翻译： 本发明涉及可用于预防和治疗细菌感染，特别是流感嗜血杆菌引起的细菌感染的米粉提取物（RFE）以及制备和使用这种抗菌米粉提取物的方法。 本发明的抗流感嗜血杆菌米粉提取物可以由市售食品级面粉或非商业食品级面粉制成。

公开(公告)号：US5837257A

公开(公告)日：1998-11-17

申请号：US863803

申请日：1997-05-27

申请人： Hsiu-Hsien Tsai ,  Shie-Ming Hwang ,  Pai-Chu Kung

发明人： Hsiu-Hsien Tsai ,  Shie-Ming Hwang ,  Pai-Chu Kung

IPC分类号： A61K36/00 ,  A61K9/20 ,  A61K9/48 ,  A61K36/28 ,  A61K36/48 ,  A61K36/539 ,  A61K36/638 ,  A61K36/81 ,  A61P31/12 ,  A61P31/18 ,  A61K35/78

CPC分类号： A61K36/00 ,  A61K36/28 ,  A61K36/48 ,  A61K36/638 ,  A61K36/81 ,  A61K9/20 ,  A61K9/48 ,  Y10S514/885 ,  Y10S514/894 ,  Y10S514/895

摘要： This invention relates to compositions derived from Chinese herbal medicines, medicinal plants and extracts thereof, and to their use for the treatment of animals infected with viruses, especially with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). More specifically, the compositions of the present invention are derived from various Chinese herbal medicines or medicinal plants which have a long history of human consumption. The compositions of the invention are obtained through specific techniques and have demonstrated outstanding efficacy for treating human HBV carriers and hepatitic C patients. Compositions according to the invention have also exhibited in vitro antiviral activities against murine leukemia virus (MuLV) and HIV. HIV is the virus known to cause acquired immunodeficiency syndrome (AIDS) in humans and AIDS presents special problems to the medical community which the present invention addresses.

摘要翻译： 本发明涉及中草药衍生物，药用植物及其提取物，以及用于治疗感染病毒，特别是乙型肝炎病毒（HBV），丙型肝炎病毒（HCV）和人类免疫缺陷病毒 （HIV）。 更具体地说，本发明的组合物衍生自具有长期人类消费历史的各种中草药或药用植物。 通过特定技术获得本发明的组合物，并且已经证明了治疗人类HBV携带者和肝癌C患者的突出功效。 根据本发明的组合物还显示针对鼠白血病病毒（MuLV）和HIV的体外抗病毒活性。 艾滋病毒是已知会导致人类获得性免疫缺陷综合征（AIDS）的病毒，艾滋病对本发明所涉及的医疗社区具有特殊问题。

公开(公告)号：US5416077A

公开(公告)日：1995-05-16

申请号：US246587

申请日：1994-05-20

申请人： Shie-Ming Hwang ,  Timothy W. Schenz ,  James N. Chmura

发明人： Shie-Ming Hwang ,  Timothy W. Schenz ,  James N. Chmura

IPC分类号： A23L29/20 ,  A23L2/52 ,  A23L2/70 ,  A23L29/256 ,  A61K47/36 ,  A61P3/02 ,  C08B37/00 ,  A23L1/0532

CPC分类号： A23L29/256

摘要： There is disclosed liquid nutritionals with improved physical stability. The nutritionals are pourable yet able to hold minerals in suspension without sedimentation or sag. The invention comprises the use of iota-carrageenan of a concentration of between 50-1500 parts per million. The nutritional may also comprise kappa carrageenan at a concentration of less than 25% of the total concentration of iota- and kappa-carrageenan. There is further disclosed a method for preparing the liquid nutritional through the use of ultra-high temperature heat treatment.

摘要翻译： 公开了具有改善的物理稳定性的液体营养物质。 营养是可倾倒的，但能够将悬浮物中的矿物质保持在没有沉淀或下垂的状态。 本发明包括使用浓度在50-1500ppm之间的ι-角叉菜聚糖。 营养物还可以包含浓度小于伊塔卡和卡拉卡拉胶总浓度的25％的卡拉卡拉酮。 还公开了通过使用超高温热处理来制备液体营养的方法。