公开(公告)号：US06200624B1

公开(公告)日：2001-03-13

申请号：US08592832

申请日：1996-01-26

申请人： Terrence Bruce Mazer ,  Robert Alan Miller ,  Charles Allan McCombs ,  Scott Donald Barnicki ,  James Cecil Phillips ,  Charles Edwan Sumner, Jr.

发明人： Terrence Bruce Mazer ,  Robert Alan Miller ,  Charles Allan McCombs ,  Scott Donald Barnicki ,  James Cecil Phillips ,  Charles Edwan Sumner, Jr.

IPC分类号： A23L200

CPC分类号： A23L33/17 ,  A23L33/12 ,  A23L33/40 ,  Y10S426/80 ,  Y10S426/801

摘要： This invention is directed to the use of triglycerides containing fatty ester moieties that include arachidonic acid (AA) and docosahexaenoic acid (DHA) in enteral nutritionals or nutritional supplements. These triglycerides are derived from lipid mixtures which have high levels of sterols and phosphorous. A preferred embodiment of the invention comprises an infant or enteral nutritional, or nutritional supplement, that comprises a lipid source derived from egg yolk. The lipid source derived from egg yolk is prepared by transesterification or hydrolysis, subjecting the mixture to distillation, and esterification with glycerin to result in a triglyceride containing the desired fatty acids of AA and DHA and little or no sterols and phosphorus.

摘要翻译： 本发明涉及含有花生四烯酸（AA）和二十二碳六烯酸（DHA）的脂肪酸酯部分的甘油三酯在肠内营养或营养补充剂中的用途。 这些甘油三酯衍生自具有高水平的甾醇和磷的脂质混合物。 本发明的优选实施方案包括婴儿或肠内营养或营养补充剂，其包含源自蛋黄的脂质源。 来自蛋黄的脂质源通过酯交换或水解制备，使混合物蒸馏，并用甘油进行酯化，得到含有所需的AA和DHA脂肪酸的甘油三酯，很少或没有固醇和磷。

公开(公告)号：US5883273A

公开(公告)日：1999-03-16

申请号：US592831

申请日：1996-01-26

申请人： Robert Alan Miller ,  Terrence Bruce Mazer ,  Charles Allan McCombs

发明人： Robert Alan Miller ,  Terrence Bruce Mazer ,  Charles Allan McCombs

IPC分类号： C11B3/12 ,  C11B7/00 ,  C11C3/04 ,  C11C3/10 ,  C11C1/00

CPC分类号： C11B3/12 ,  C11B7/0008 ,  C11C3/04 ,  C11C3/10

摘要： Fatty acid esters such as those containing arachidonic acid (AA) and docosahexaenoic acid (DHA) derived from lipid mixtures are prepared with reduced levels of sterols and phosphorus. A preferred embodiment of the invention comprises extracting lipids from egg with methanol; separating lipids including sterols from insoluble egg components; submitting the methanolic solution of lipids to transesterification and subsequent neutralization to convert the lipids to methyl esters of said free fatty acids together with sterols; separating the said sterols and esters from an aqueous phase including phosphorus compounds formed in the transesterification; subjecting the said fatty acid esters and sterols to distillation to separate sterols from the fatty acid esters; and subjecting the said esters to transesterification in the presence of glycerol to produce triglycerides of said esters thereof including that of AA and DHA wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus.

摘要翻译： 脂肪酸酯如含有花生四烯酸（AA）和来源于脂质混合物的二十二碳六烯酸（DHA）的脂肪酸酯被制备成具有降低水平的固醇和磷。 本发明的优选实施方案包括用甲醇从鸡蛋中提取脂质; 分离包括固醇的脂质不溶于蛋组分; 将脂质的甲醇溶液酯交换并随后中和，将脂质与甾醇一起转化成所述游离脂肪酸的甲酯; 将所述甾醇和酯与包含在酯交换中形成的磷化合物的水相分离; 对所述脂肪酸酯和甾醇进行蒸馏以将甾醇与脂肪酸酯分离; 并在所述甘油存在下使所述酯进行酯交换反应以产生所述酯的甘油三酸酯，其包括AA和DHA的甘油三酯，其中所得甘油三酸酯含有减少量的甾醇和磷。

公开(公告)号：US6103943A

公开(公告)日：2000-08-15

申请号：US9345

申请日：1998-01-20

申请人： Charles Allan McCombs

发明人： Charles Allan McCombs

IPC分类号： C07B61/00 ,  C07C29/10 ,  C07C33/025

CPC分类号： C07C29/106

摘要： Disclosed is a process for the synthesis of 3-buten-1-ol by contacting 3,4-epoxy-1-butene and formic acid with a homogeneous catalyst solution comprising a palladium(0) compound, a tertiary phosphine and a trialkylamine dissolved in tetrahydrofuran.

摘要翻译： 公开了通过使3,4-环氧-1-丁烯和甲酸与均匀的催化剂溶液接触来合成3-丁烯-1-醇的方法，所述均相催化剂溶液包含钯（0）化合物，叔膦和三烷基胺溶于 四氢呋喃。