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    Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds
    2.
    发明授权
    Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds 失效
    用于从含有甾醇和磷化合物的复杂混合物中分离多不饱和脂肪酸及其酯的方法

    公开(公告)号：US6063946A

    公开(公告)日：2000-05-16

    申请号：US592797

    申请日：1996-01-26

    申请人： Robert Alan Miller ,  Terrence Bruce Mazer ,  Scott Donald Barnicki ,  Charles Edwan Sumner, Jr.

    发明人： Robert Alan Miller ,  Terrence Bruce Mazer ,  Scott Donald Barnicki ,  Charles Edwan Sumner, Jr.

    IPC分类号： A23L5/20 ,  C11C1/02 ,  C11C1/10 ,  C11C3/00 ,  C11C3/02 ,  C11C1/00

    CPC分类号： C11C3/02 ,  C11C1/025 ,  C11C1/10 ,  C11C3/003

    摘要： This invention relates to a process for the isolation of fatty acids and fatty acid esters from complex naturally occurring mixtures which contain sterols, triglycerides and phospholipids. A preferred embodiment of the invention comprises extracting lipids from egg yolk solids with methanol; separating lipids including sterols from insoluble egg yolk components; submitting the methanolic solution of lipids to (a) alkaline hydrolysis and subsequent neutralization to convert lipids to free fatty acids together with sterols; (b) separating the said sterols and acids from an aqueous phase formed in the hydrolysis reaction; (c) heating said free fatty acids and sterols to convert the sterols to fatty acid sterol esters; (d) subjecting the mixture to distillation to separate the sterol esters from the free fatty acids; and (e) subjecting the said acids to esterification in the presence of glycerol to produce triglycerides of said fatty acids wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus. An enteral nutritional formula containing the triglycerides produced in the above process is also disclosed.

    摘要翻译： 本发明涉及从含有甾醇，甘油三酯和磷脂的复杂天然存在的混合物中分离脂肪酸和脂肪酸酯的方法。 本发明的优选实施方案包括用甲醇从蛋黄固体中提取脂质; 分离包括固醇的脂质不溶于蛋黄成分; 将脂质的甲醇溶液（a）碱性水解并随后中和，将脂质与甾醇一起转化为游离脂肪酸; （b）将所述甾醇和酸与水解反应中形成的水​​相分离; （c）加热所述游离脂肪酸和甾醇以将甾醇转化为脂肪酸甾醇酯; （d）使混合物进行蒸馏以将固醇酯与游离脂肪酸分离; 和（e）在甘油存在下使所述酸进行酯化以产生所述脂肪酸的甘油三酯，其中所得甘油三酸酯含有降低量的甾醇和磷。 还公开了含有在上述方法中生产的甘油三酯的肠内营养配方。

    Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds
    3.
    发明授权
    Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds 失效
    多不饱和脂肪酸和不含甾醇和磷化合物的脂肪酸酯

    公开(公告)号：US5883273A

    公开(公告)日：1999-03-16

    申请号：US592831

    申请日：1996-01-26

    申请人： Robert Alan Miller ,  Terrence Bruce Mazer ,  Charles Allan McCombs

    发明人： Robert Alan Miller ,  Terrence Bruce Mazer ,  Charles Allan McCombs

    IPC分类号： C11B3/12 ,  C11B7/00 ,  C11C3/04 ,  C11C3/10 ,  C11C1/00

    CPC分类号： C11B3/12 ,  C11B7/0008 ,  C11C3/04 ,  C11C3/10

    摘要： Fatty acid esters such as those containing arachidonic acid (AA) and docosahexaenoic acid (DHA) derived from lipid mixtures are prepared with reduced levels of sterols and phosphorus. A preferred embodiment of the invention comprises extracting lipids from egg with methanol; separating lipids including sterols from insoluble egg components; submitting the methanolic solution of lipids to transesterification and subsequent neutralization to convert the lipids to methyl esters of said free fatty acids together with sterols; separating the said sterols and esters from an aqueous phase including phosphorus compounds formed in the transesterification; subjecting the said fatty acid esters and sterols to distillation to separate sterols from the fatty acid esters; and subjecting the said esters to transesterification in the presence of glycerol to produce triglycerides of said esters thereof including that of AA and DHA wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus.

    摘要翻译： 脂肪酸酯如含有花生四烯酸（AA）和来源于脂质混合物的二十二碳六烯酸（DHA）的脂肪酸酯被制备成具有降低水平的固醇和磷。 本发明的优选实施方案包括用甲醇从鸡蛋中提取脂质; 分离包括固醇的脂质不溶于蛋组分; 将脂质的甲醇溶液酯交换并随后中和，将脂质与甾醇一起转化成所述游离脂肪酸的甲酯; 将所述甾醇和酯与包含在酯交换中形成的磷化合物的水相分离; 对所述脂肪酸酯和甾醇进行蒸馏以将甾醇与脂肪酸酯分离; 并在所述甘油存在下使所述酯进行酯交换反应以产生所述酯的甘油三酸酯，其包括AA和DHA的甘油三酯，其中所得甘油三酸酯含有减少量的甾醇和磷。