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14 条记录 (耗时 0.018 秒)

    Method for raising the hypoxic threshold
    3.
    发明授权
    Method for raising the hypoxic threshold 有权
    提高缺氧阈值的方法

    公开(公告)号：US06218366B1

    公开(公告)日：2001-04-17

    申请号：US09406266

    申请日：1999-09-24

    申请人： John St. Cyr ,  Clarence A. Johnson ,  Dean J. MacCarter ,  Stephen G. Sawada

    发明人： John St. Cyr ,  Clarence A. Johnson ,  Dean J. MacCarter ,  Stephen G. Sawada

    IPC分类号： A61K3170

    CPC分类号： A61K33/06 ,  A61K31/7004 ,  A61K45/06 ,  A61K31/195 ,  A61K2300/00

    摘要： The administration of ribose raises the hypoxic threshold of mammals experiencing a hypoxic condition. The presence of an effective amount of ribose in the tissue of a mammal increases the tolerance to hypoxia and decreases the symptoms of hypoxia in mammals experiencing chronic hypoxia due to cardiovascular disease or peripheral vascular disease. Such mammals are additionally benefited by administration of ribose and a vasodilator or an isotropic agent. Mammals experiencing transient hypoxia from high altitude, anesthesia or exercise are also benefited.

    摘要翻译： 核糖的施用提高了经历缺氧条件的哺乳动物的缺氧阈值。 在哺乳动物组织中存在有效量的核糖增加对缺氧的耐受性，并降低由于心血管疾病或外周血管疾病而经历慢性缺氧的哺乳动物的缺氧症状。 通过给予核糖和血管扩张剂或各向同性剂，这些哺乳动物另外受益。 从高空，麻醉或运动中经历短暂缺氧的哺乳动物也受益匪浅。

    Storage of blood
    4.
    发明申请
    Storage of blood 有权
    储存血液

    公开(公告)号：US20070111191A1

    公开(公告)日：2007-05-17

    申请号：US11650241

    申请日：2007-01-05

    申请人： John St. Cyr ,  Daniel Ericson ,  Clarence Johnson

    发明人： John St. Cyr ,  Daniel Ericson ,  Clarence Johnson

    IPC分类号： A01N1/02 ,  A61K31/70

    CPC分类号： A01N1/02 ,  A01N1/0226

    摘要： A ribose-related compound is added to whole blood or packed red cells which have suboptimal function as measured by decreased levels of 2,3-DPG in order to rejuvenate the red blood cells to normal function as seen by raised levels of 2,3-DPG. Two representative ribose-related compounds are D-ribose and inosine.

    摘要翻译： 通过降低2,3-DPG的水平来测定具有次优功能的全血或包装的红细胞中的核糖相关化合物，以便将红细胞恢复正常，如升高的2,3- DPG。 两种代表性的与核糖相关的化合物是D-核糖和肌苷。

    Compositions for increasing energy in vivo
    5.
    发明授权
    Compositions for increasing energy in vivo 有权
    用于增加体内能量的组合物

    公开(公告)号：US06534480B2

    公开(公告)日：2003-03-18

    申请号：US09740255

    申请日：2000-12-18

    申请人： John St. Cyr ,  Clarence A. Johnson

    发明人： John St. Cyr ,  Clarence A. Johnson

    IPC分类号： A61K3170

    CPC分类号： A61K31/7004 ,  A23L33/10 ,  A23V2002/00 ,  A23V2250/626 ,  A23V2250/161 ,  A23V2250/306 ,  A23V2250/0606 ,  A23V2250/0612

    摘要： Precursors of adenosine triphosphate are administered orally to increase intracellular ATP concentration as dietary supplements or for treatment of reduced energy availability resulting from strenuous physical activity, illness or trauma. Pentose sugars are administered individually, mixed into dry food or in solution. The preferred pentose is D-ribose, singly or combined with creatine, pyruvate, L-carnitine and/or vasodilating agents. Additionally, magnesium, electrolytes, fatty acids and hexose sugars can be used. The compositions and methods of this invention are especially beneficial to mammals having reduced energy availability or high energy demand.

    摘要翻译： 口服三磷酸腺苷的前体以增加细胞内ATP浓度作为膳食补充剂或用于治疗由剧烈的身体活动，疾病或创伤引起的能量可用性降低。 戊糖分别单独施用，混入干燥食物或溶液中。 优选的戊糖是D-核糖，单独或与肌酸，丙酮酸，L-肉毒碱和/或血管舒张剂组合。 另外，可以使用镁，电解质，脂肪酸和己糖。 本发明的组合物和方法对具有降低的能量可用性或高能量需求的哺乳动物特别有益。

    Use of ribose in recovery from anaesthesia
    7.
    发明申请
    Use of ribose in recovery from anaesthesia 审中-公开
    使用核糖从麻醉恢复

    公开(公告)号：US20070105787A1

    公开(公告)日：2007-05-10

    申请号：US11036522

    申请日：2005-01-14

    申请人： John St. Cyr ,  Daniel Perkowski

    发明人： John St. Cyr ,  Daniel Perkowski

    IPC分类号： A61K31/70 ,  A01N43/04

    CPC分类号： A61K31/70

    摘要： D-Ribose is administered before and after general anaesthesia to reduce the time to recover from the effects of general anaesthesia. Preferably, pyrogen-free D-Ribose is administered intravenously during general anaesthesia and the interval post-anaesthesia before oral administration can be resumed. D-Glucose may be co-administered to reduce the effect of hypoglycemia that may be seen with D-Ribose administration.

    摘要翻译： 全身麻醉前后给予D-核糖，以减少从全身麻醉效果中恢复的时间。 优选地，在全身麻醉期间静脉内施用无热原的D-核糖，并且可以恢复在口服给药之前的间歇麻醉后间期。 D-葡萄糖可以共同施用以降低D-核糖给药可以看出的低血糖的作用。

    Method for determining viability of a myocardial segment
    10.
    发明授权
    Method for determining viability of a myocardial segment 失效
    确定心肌段生存能力的方法

    公开(公告)号：US06339716B1

    公开(公告)日：2002-01-15

    申请号：US09405462

    申请日：1999-09-24

    申请人： Stephen G. Sawada ,  John St. Cyr ,  Clarence A. Johnson

    发明人： Stephen G. Sawada ,  John St. Cyr ,  Clarence A. Johnson

    IPC分类号： A61B505

    CPC分类号： A61K49/0004 ,  A61K49/226 ,  A61K51/02 ,  A61K51/04

    摘要： A method of determining the viability of a hibernating or stunned myocardial segment comprises the administration of ribose, a vasodilator and an inotropic agent. The preferred agent is dobutamine, which has both a vasodilation and an inotropic effect. The segments may be identified by myocardial imaging by any known means, such as echocardiography, Thallium-201 tracing or positron emission tomography. Ribose is preferably given one minute to three hours prior to administration of the vasodilator and inotropic agents.

    摘要翻译： 确定冬眠或昏迷的心肌节段的活力的方法包括施用核糖，血管扩张剂和变力剂。 优选的药物是多巴酚丁胺，其具有血管舒张和变力作用。 可以通过任何已知的手段，例如超声心动图，铊-201跟踪或正电子发射断层扫描，通过心肌成像来鉴定节段。 优选在施用血管扩张剂和变力剂之前1分钟至3小时给予核糖。