公开(公告)号：US20230271908A1

公开(公告)日：2023-08-31

申请号：US18027897

申请日：2021-09-23

申请人： Tetra Bio-Pharma Inc.

发明人： Harpreet Kaur ,  Xuejun Liu ,  Prabin Nepal ,  Subakar Paramanantham ,  Monika Garg ,  Zemin Li ,  Andy Tjeng ,  Moises Rodriguez ,  Laura Jong ,  Azam Mirzahossein ,  Ofer Yifrach-Stav ,  Erin Bassett ,  Randy Ringuette ,  Charles Campbell ,  Melanie Kelly

IPC分类号： C07C41/26

CPC分类号： C07C41/26 ,  C07B2200/07 ,  C07C2602/42

摘要： Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.

公开(公告)号：US12129227B2

公开(公告)日：2024-10-29

申请号：US18027897

申请日：2021-09-23

申请人： Tetra Bio-Pharma Inc.

发明人： Harpreet Kaur ,  Xuejun Liu ,  Prabin Nepal ,  Subakar Paramanantham ,  Monika Garg ,  Zemin Li ,  Andy Tjeng ,  Moises Rodriguez ,  Laura Jong ,  Azam Mirzahossein ,  Ofer Yifrach-Stav ,  Erin Bassett ,  Randy Ringuette ,  Charles Campbell ,  Melanie Kelly

IPC分类号： C07C41/26 ,  C07C29/48 ,  C07C67/08 ,  C07C67/29 ,  C07C67/293 ,  C07C269/06

CPC分类号： C07C41/26 ,  C07C29/48 ,  C07C67/08 ,  C07C67/29 ,  C07C67/293 ,  C07C269/06 ,  C07B2200/07 ,  C07C2602/42 ,  C07C41/26 ,  C07C43/23 ,  C07C269/06 ,  C07C271/22 ,  C07C29/48 ,  C07C33/14 ,  C07C67/08 ,  C07C69/24 ,  C07C67/29 ,  C07C69/24 ,  C07C67/293 ,  C07C69/24

摘要： Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.