公开(公告)号：US4581355A

公开(公告)日：1986-04-08

申请号：US680727

申请日：1984-12-12

申请人： Tetsuya Tahara ,  Tsuguo Ikebe ,  Yutaka Maruyama ,  Osamu Yaoka ,  Yohji Miura

发明人： Tetsuya Tahara ,  Tsuguo Ikebe ,  Yutaka Maruyama ,  Osamu Yaoka ,  Yohji Miura

IPC分类号： A61K31/40 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/55 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/28 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D403/12

摘要： 3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl; each of R.sup.2 and R.sup.3 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, benzyloxy, C.sub.2-6 alkanoyloxy or hydroxy; R.sup.4 is hydrogen or C.sub.1-4 alkyl; R.sup.5 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy; R.sup.6 is hydrogen or C.sub.1-4 alkyl; X is oxygen, sulfur or direct bond; each of k and m is an integer of 1 to 3; and n is 1 or 2, are useful as drug for the prevention and treatment of various circulatory diseases.

摘要翻译： 具有下式的3-吲哚甲酰胺化合物：包括其药学上可接受的酸加成盐和/或其水合物形式，其中R 1是氢或C 1-4烷基; R 2和R 3各自为氢，卤素，C 1-4烷基，C 1-4烷氧基，苄氧基，C 2-6烷酰氧基或羟基; R4是氢或C1-4烷基; R5是氢，卤素，C1-4烷基，C1-4烷氧基或羟基; R6是氢或C1-4烷基; X是氧，硫或直接键; k和m各自为1〜3的整数， 和n为1或2，可用作预防和治疗各种循环系统疾病的药物。