公开(公告)号：US20160108041A1

公开(公告)日：2016-04-21

申请号：US14977011

申请日：2015-12-21

Applicant: The Asan Foundation

Inventor： Gilnam Lee ,  Hye Sun Jeon ,  Ki Joon Jeon ,  Chul Yun Rhim ,  Jin Sung Kim ,  Jeongbeob Seo ,  Suk Young Cho ,  Choung Soo Kim ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jung Jin Hwang ,  Bongcheol Kim

IPC: C07D471/04 ,  C07D413/04 ,  C07D221/04

CPC classification number: C07D471/04 ,  C07D221/04 ,  C07D271/10 ,  C07D271/113 ,  C07D413/04

Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

Abstract translation: 本发明提供由式I和式II表示的新型取代的杂环化合物或其药学上可接受的盐，溶剂合物，多晶型物，酯，互变异构体或前药，以及包含这些化合物的组合物。 所提供的化合物可用作MEK的抑制剂，并且可用于治疗炎性疾病，癌症和其它过度增生性疾病。 本发明还提供了一种治疗哺乳动物，特别是人类的炎性疾病，癌症和其它过度增生性疾病的方法。

公开(公告)号：US20140113915A1

公开(公告)日：2014-04-24

申请号：US14137158

申请日：2013-12-20

Applicant: The Asan Foundation

Inventor： Gilnam Lee ,  Chul Soo Lim ,  Han Won Cho ,  Jeongbeob Seo ,  Albert C. Gyorkos ,  Suk Young Cho ,  Eun Kyung Choi ,  Choung Soo Kim ,  Jung Jin Hwang

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/519

Abstract: The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3′ OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders.

Abstract translation: 本发明提供由式I表示的新型取代吡啶并嘧啶以及其药学上可接受的盐，溶剂合物，多晶型物，酯，互变异构体或前药，以及包含这些化合物的组合物。 所提供的化合物可用作磷酸肌醇3'OH激酶家族（PI3K）的抑制剂，用于治疗炎性疾病，癌症，心血管疾病，变态反应，哮喘和自身免疫性疾病。

公开(公告)号：US09617261B2

公开(公告)日：2017-04-11

申请号：US14977011

申请日：2015-12-21

Applicant: The Asan Foundation

Inventor： Gilnam Lee ,  Hye Sun Jeon ,  Ki Joon Jeon ,  Chul Yun Rhim ,  Jin Sung Kim ,  Jeongbeob Seo ,  Suk Young Cho ,  Choung Soo Kim ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jung Jin Hwang ,  Bongcheol Kim

IPC: C07D221/04 ,  C07D471/04 ,  C07D271/10 ,  C07D271/113 ,  C07D413/04

CPC classification number: C07D471/04 ,  C07D221/04 ,  C07D271/10 ,  C07D271/113 ,  C07D413/04

Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.