公开(公告)号：US20160108041A1

公开(公告)日：2016-04-21

申请号：US14977011

申请日：2015-12-21

Applicant: The Asan Foundation

Inventor： Gilnam Lee ,  Hye Sun Jeon ,  Ki Joon Jeon ,  Chul Yun Rhim ,  Jin Sung Kim ,  Jeongbeob Seo ,  Suk Young Cho ,  Choung Soo Kim ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jung Jin Hwang ,  Bongcheol Kim

IPC: C07D471/04 ,  C07D413/04 ,  C07D221/04

CPC classification number: C07D471/04 ,  C07D221/04 ,  C07D271/10 ,  C07D271/113 ,  C07D413/04

Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

Abstract translation: 本发明提供由式I和式II表示的新型取代的杂环化合物或其药学上可接受的盐，溶剂合物，多晶型物，酯，互变异构体或前药，以及包含这些化合物的组合物。 所提供的化合物可用作MEK的抑制剂，并且可用于治疗炎性疾病，癌症和其它过度增生性疾病。 本发明还提供了一种治疗哺乳动物，特别是人类的炎性疾病，癌症和其它过度增生性疾病的方法。

公开(公告)号：US09617261B2

公开(公告)日：2017-04-11

申请号：US14977011

申请日：2015-12-21

Applicant: The Asan Foundation

Inventor： Gilnam Lee ,  Hye Sun Jeon ,  Ki Joon Jeon ,  Chul Yun Rhim ,  Jin Sung Kim ,  Jeongbeob Seo ,  Suk Young Cho ,  Choung Soo Kim ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jung Jin Hwang ,  Bongcheol Kim

IPC: C07D221/04 ,  C07D471/04 ,  C07D271/10 ,  C07D271/113 ,  C07D413/04

CPC classification number: C07D471/04 ,  C07D221/04 ,  C07D271/10 ,  C07D271/113 ,  C07D413/04

Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.