公开(公告)号：US20240261440A1

公开(公告)日：2024-08-08

申请号：US18419370

申请日：2024-01-22

Applicant: The Board of Regents of The University of Texas System

Inventor： Tuo WEI ,  Yehui SUN ,  Qiang CHENG ,  Daniel SIEGWART

IPC: A61K48/00 ,  A61K31/7088 ,  A61K38/46 ,  A61K47/24 ,  A61K47/54 ,  C07K14/705 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N15/90

CPC classification number: A61K48/0066 ,  A61K31/7088 ,  A61K38/465 ,  A61K47/24 ,  A61K47/543 ,  C07K14/705 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

Abstract: Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.