专利检索 ap:("The Board of Regents of the University of Oklahoma") AND inv:"Patrick H. Mckernan" 第 1 页

1.

发明申请
Antimalarial Enzyme Conjugates, Kits Containing Same, and Methods of Producing and Using Same 有权

公开(公告)号：US20210177948A1

公开(公告)日：2021-06-17

申请号：US16331634

申请日：2018-08-09

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, Jr. , Patrick H. Mckernan

IPC分类号： A61K38/51 , A61K45/06 , A61K47/60 , C12N9/88

摘要： A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected with Plasmodium pathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating Plasmodium-infected blood by exposing the infected blood with the enzyme conjugate.