专利检索 ap:("The Board of Regents of the University of Oklahoma") AND inv:"Roger G. Harrison, Jr." 第 1 页

1.

发明授权
Compositions and methods for cancer treatment using targeted carbon nanotubes 有权
标题翻译：使用靶向碳纳米管的癌症治疗的组合物和方法

公开(公告)号：US09504745B2

公开(公告)日：2016-11-29

申请号：US14100892

申请日：2013-12-09

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, Jr. , Daniel E. Resasco , Luis Filipe Ferreira Neves

IPC分类号： A61K41/00 , A61N1/40 , A61K38/17 , A61K45/06 , A61K47/48 , B82Y5/00 , A61N2/02 , A61N5/06

CPC分类号： A61K41/0052 , A61K38/1709 , A61K45/06 , A61K47/48215 , A61K47/48246 , A61K47/48869 , A61K47/48884 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6929 , A61N1/406 , A61N2/02 , A61N5/062 , A61N2005/0659 , B82Y5/00 , A61K2300/00

摘要： Compositions for detecting and/or destroying cancer tumors and/or cancer cells via photodynamic therapy are disclosed, as well as methods of use thereof. The compositions comprise a linking protein or peptide attached to or otherwise physically associated with a carbon nanotube to form a targeted protein-carbon nanotube complex.

摘要翻译： 公开了通过光动力疗法检测和/或破坏癌肿瘤和/或癌细胞的组合物，以及其使用方法。组合物包含与碳纳米管连接或以其他方式物理相联系的连接蛋白或肽，以形成靶向的蛋白质 - 碳纳米管复合物。

2.

发明授权
Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same 有权

公开(公告)号：US11446365B2

公开(公告)日：2022-09-20

申请号：US16331634

申请日：2018-08-09

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, Jr. , Patrick H. McKernan

IPC分类号： A61K38/51 , A61K47/60 , A61K45/06 , C12N9/88 , A61K31/223

摘要： A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected with Plasmodium pathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating Plasmodium-infected blood by exposing the infected blood with the enzyme conjugate.

3.

发明申请
Antimalarial Enzyme Conjugates, Kits Containing Same, and Methods of Producing and Using Same 有权

公开(公告)号：US20210177948A1

公开(公告)日：2021-06-17

申请号：US16331634

申请日：2018-08-09

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, Jr. , Patrick H. Mckernan

IPC分类号： A61K38/51 , A61K45/06 , A61K47/60 , C12N9/88

摘要： A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected with Plasmodium pathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating Plasmodium-infected blood by exposing the infected blood with the enzyme conjugate.

4.

发明授权
Enzyme conjugate and prodrug cancer therapy 有权

公开(公告)号：US09987241B2

公开(公告)日：2018-06-05

申请号：US14865650

申请日：2015-09-25

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, Jr. , John J. Krais

IPC分类号： A61K39/385 , A61K31/198 , A61K38/51 , A61K31/436 , A61K31/664 , A61K45/06 , A61K31/675 , C12N9/88 , A61K47/66

CPC分类号： A61K31/198 , A61K31/436 , A61K31/664 , A61K31/675 , A61K38/51 , A61K45/06 , A61K47/67 , C12N9/88 , C12Y404/01001 , A61K2300/00

摘要： A method and composition for treating a cancerous tumor in a subject by targeting the tumor's vasculature using an enzyme conjugate comprising a ligand which binds to endothelial cells in the tumor vasculature and converts a prodrug administered to the subject into an anticancer drug in the tumor vasculature.