公开(公告)号：US20180057888A1

公开(公告)日：2018-03-01

申请号：US15557608

申请日：2016-03-08

Applicant: The Board of Regents of the University of Texas System

Inventor： David A. BOOTHMAN ,  Edward A. MOTEA ,  Praveen PATIDAR ,  Julio MORALES

IPC: C12Q1/68 ,  C12N15/113 ,  A61N5/10

CPC classification number: C12Q1/6886 ,  A61N5/10 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y204/0203 ,  G01N33/574 ,  G01N2333/4703 ,  G01N2800/52 ,  G01N2800/56

Abstract: The present disclosure is directed to methods of detecting KUB5/HERA expression levels, copy number and mutation status, particularly in cancer cells. The methods permit physicians to tailor therapies to subject having certain genotypes/phenotypes, and to exclude therapies unlikely to be effective.