公开(公告)号：US20240241113A1

公开(公告)日：2024-07-18

申请号：US18289576

申请日：2022-05-06

申请人： Oulun Yliopisto

发明人： Lari Lehtiö ,  Sven Sowa ,  Albert Galera-Prat

IPC分类号： G01N33/542 ,  C07K14/47 ,  C12Q1/48

CPC分类号： G01N33/542 ,  C07K14/4702 ,  C12Q1/48 ,  C07K2319/60 ,  C12Y204/0203 ,  G01N2333/235 ,  G01N2333/91142 ,  G01N2440/38

摘要： The present invention is directed to a method, kit, system and fusion protein for detecting binding to an ADP-ribosyl group or a polymer thereof, wherein said group or polymer is coupled to a peptide or protein, the method comprising the steps of: i) providing a first entity comprising a first label or tag, said entity comprising an amino acid sequence comprising a cysteine residue whereto at least one ADP-ribosyl group or an analog thereof is coupled via an S-glycosidic bond; ii) contacting in an assay said first entity with a second entity, said second entity being or suspected of being capable of binding to an ADP-ribosyl group or polymer thereof coupled to a peptide or protein; and iii) measuring a signal derived from said first label or localized by said tag, wherein the signal detected is different or is localized differently when said second entity binds to said at least one ADP-ribosyl group of the first entity from the signal detected when the binding interaction between said second entity and said ADP-ribosyl group has not occurred. The kit of the present invention provides means to perform the method of the invention.

公开(公告)号：US11793860B2

公开(公告)日：2023-10-24

申请号：US16991780

申请日：2020-08-12

申请人： The Regents of the University of California ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Leonard H. Rome ,  Valerie Ann Kickhoefer ,  Steven M. Dubinett ,  Sherven Sharma ,  Upendra K. Kar

IPC分类号： A61K38/19 ,  C07K14/52 ,  A61K47/69 ,  A61K38/00 ,  A61K38/45 ,  C12N9/10 ,  A61K35/12 ,  A61K48/00 ,  C07H21/00 ,  C07K7/06 ,  C07K14/47 ,  C12N5/0783 ,  C12N9/96 ,  C12N15/86 ,  G01N33/535

CPC分类号： A61K38/195 ,  A61K38/00 ,  A61K38/45 ,  A61K47/6921 ,  C07K14/521 ,  C12N9/1077 ,  C12Y204/0203 ,  A61K35/12 ,  A61K48/00 ,  C07H21/00 ,  C07K7/06 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/01 ,  C12N5/0636 ,  C12N9/96 ,  C12N15/86 ,  G01N33/535

摘要： The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.

公开(公告)号：US20180110777A1

公开(公告)日：2018-04-26

申请号：US15557393

申请日：2016-03-18

申请人： The Johns Hopkins University

发明人： Carol W. Greider ,  Stella S. Lee

IPC分类号： A61K31/502 ,  C12Q1/6851 ,  C12Q1/686 ,  C12N9/10 ,  C12N9/12 ,  A61P7/00 ,  A61P7/06 ,  A61P11/00 ,  A61P35/00 ,  A61P17/00

CPC分类号： A61K31/502 ,  A61K31/4184 ,  A61K31/55 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K45/06 ,  A61P7/00 ,  A61P7/06 ,  A61P11/00 ,  A61P17/00 ,  A61P35/00 ,  C12N9/1077 ,  C12N9/12 ,  C12N15/1137 ,  C12N15/86 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3231 ,  C12N2310/531 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Y204/0203 ,  C12Y207/11022 ,  A61K2300/00

摘要： Provided herein are methods for increasing telomere length comprising contacting a cell with an agent that activates the ataxia telangiectasia mutated (ATM) kinase pathway or a cyclin dependent kinase pathway, thereby elongating telomeres in the cell. Also provided is a method for treating disorders such as cancer and telomere syndromes.

公开(公告)号：US20180000822A1

公开(公告)日：2018-01-04

申请号：US15650459

申请日：2017-07-14

申请人： The University of Sheffield

发明人： Thomas Helleday

IPC分类号： A61K31/517 ,  A61K38/00 ,  A61K31/472 ,  C07D487/06 ,  C12N15/113 ,  A61K31/5517

CPC分类号： A61K31/517 ,  A61K31/472 ,  A61K31/5517 ,  A61K38/005 ,  C07D487/06 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/30 ,  C12Y204/0203

摘要： The present invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.

公开(公告)号：US08747841B2

公开(公告)日：2014-06-10

申请号：US13262607

申请日：2010-03-31

申请人： Gudrun Ahnert-Hilger ,  Gisela Groβe ,  Fred Hofmann ,  Ingo Just ,  Markus Höltje ,  Stefanie Hülsenbeck

发明人： Gudrun Ahnert-Hilger ,  Gisela Groβe ,  Fred Hofmann ,  Ingo Just ,  Markus Höltje ,  Stefanie Hülsenbeck

IPC分类号： A61K38/00 ,  A61K39/08 ,  A01N63/00 ,  C12N9/10

CPC分类号： A61K38/00 ,  C12N9/1077 ,  C12Y204/0203 ,  Y02A50/469

摘要： The present invention relates to polypeptides transiently activating Ras homolog gene family member A (RhoA) GTPase, polynucleotides encoding said polypeptides and pharmaceutical compositions comprising said polypeptides or said polynucleotides. The present invention further relates to the use of said polypeptides, said polynucleotides or said pharmaceutical compositions for long-term treatment of damage of the peripheral or central nervous system.

摘要翻译： 本发明涉及瞬时激活Ras同源基因家族成员A（RhoA）GTPase，编码所述多肽的多核苷酸和包含所述多肽或所述多核苷酸的药物组合物的多肽。 本发明还涉及所述多肽，所述多核苷酸或所述药物组合物用于长期治疗外周或中枢神经系统损伤的用途。

公开(公告)号：US20130180006A1

公开(公告)日：2013-07-11

申请号：US13445288

申请日：2012-04-12

申请人： Andrew Mark Cigan ,  Shai J. Lawit

发明人： Andrew Mark Cigan ,  Shai J. Lawit

IPC分类号： C12N15/82 ,  A01H5/10 ,  C12N5/10

CPC分类号： C12N15/8231 ,  C12N9/1077 ,  C12N9/22 ,  C12N15/8261 ,  C12N15/8263 ,  C12Y204/0203 ,  C12Y301/27

摘要： Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences encompasses a strong pollen preferred promoter which drives strong, specific expression of gene products in pollen. Also provided is a method for expressing a heterologous nucleotide sequence in a plant using a promoter sequence disclosed herein.

摘要翻译： 提供了用于调节植物中异源核苷酸序列表达的组合物和方法。 组合物包括核苷酸序列包括强花粉优选启动子，其驱动花粉中基因产物的强烈，特异性表达。 还提供了使用本文公开的启动子序列在植物中表达异源核苷酸序列的方法。

公开(公告)号：US07531530B2

公开(公告)日：2009-05-12

申请号：US10565308

申请日：2004-07-23

申请人： Thomas Helleday ,  Nicola Curtin

发明人： Thomas Helleday ,  Nicola Curtin

IPC分类号： A61P35/00

CPC分类号： C07D487/06 ,  A61K31/5517 ,  A61K38/005 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y204/0203

摘要： The invention relates to trycyclic lactam indole derivatives and triacyclic lactam benzimodole derivatives and their use in inhibiting the activity of PARP enzyme. The invention also relates to the use of these compounds in the preparation of medicaments.

摘要翻译： 本发明涉及三环内酰胺衍生物和三环内酰胺苯并三唑衍生物及其在抑制PARP酶活性中的应用。 本发明还涉及这些化合物在制备药物中的用途。

公开(公告)号：US20040265286A1

公开(公告)日：2004-12-30

申请号：US10840275

申请日：2004-05-07

申请人： UNIVERSITE LAVAL

发明人： Serge Desnoyers

IPC分类号： C07H021/04 ,  A61K048/00 ,  A61K031/47 ,  A61K031/165

CPC分类号： A61K31/165 ,  A61K31/47 ,  C12N9/1077 ,  C12N9/2402 ,  C12Y204/0203 ,  C12Y302/01143 ,  A61K2300/00

摘要： The present invention relates to a method, nucleic acid and amino acid sequences to sensitizing human or animal cells to be killed by chemical entities or irradiation. Particularly, the present invention describes nucleic acid and amino acid sequences pertaining to the group of PME factors, that are target to sensitizing the cells before treatment with killing elemenst.

摘要翻译： 本发明涉及使化学实体或辐照杀死的人或动物细胞敏化的方法，核酸和氨基酸序列。 特别地，本发明描述了与PME因子组有关的核酸和氨基酸序列，其目标是在用杀死elemenst进行治疗前使细胞敏化。

公开(公告)号：US06599727B1

公开(公告)日：2003-07-29

申请号：US09596248

申请日：2000-06-16

申请人： Erik Christenson ,  Anthony J. Demaggio ,  Phyllis S. Goldman ,  David L. McElligott

发明人： Erik Christenson ,  Anthony J. Demaggio ,  Phyllis S. Goldman ,  David L. McElligott

IPC分类号： C12N912

CPC分类号： C12N9/1077 ,  A61K38/00 ,  C12Y204/0203

摘要： The invention provides a novel human poly(ADP-ribose) polymerase (hPARP2) polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing the hPARP2 polypeptides, antibodies that are immunoreactive with the hPARP2 polypeptides. In addition, there are provided methods for identifying specific binding partners of hPARP2, and more particularly methods for identifying binding partners that modulate biological activity of hPARP2. Methods of modulating biological activity of hPARP2 in vitro and in vivo are also provided.

公开(公告)号：US20180201899A1

公开(公告)日：2018-07-19

申请号：US15744216

申请日：2016-07-15

申请人： Northwestern University

发明人： Guillermo A. Ameer ,  Bin Jiang ,  Michele Jen ,  Jason A. Wertheim

IPC分类号： C12N5/071 ,  A61K35/44 ,  A61K38/50 ,  C12N9/80 ,  G01N33/50

CPC分类号： C12N5/069 ,  A01N1/0226 ,  A61K35/44 ,  A61K38/50 ,  C12N5/0696 ,  C12N9/1077 ,  C12N9/80 ,  C12N15/00 ,  C12N2501/72 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2740/16043 ,  C12Y204/0203 ,  G01N33/5014 ,  G01N33/502

摘要： Compositions comprising endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSC)that over-express Sirtuin 1 (SIRT1) are disclosed. Further disclosed are methods of preparation of the compositions, and methods for treating a subject comprising administering transplatanbe cells, tissue, or organ comprising the iPSC-derived ECs overexpressing SIRT1, as well as methods of testing an agent for therapeutic efficacy and toxicity using the compositions.