公开(公告)号：US20140364467A1

公开(公告)日：2014-12-11

申请号：US14310619

申请日：2014-06-20

Applicant: The Board of Regents of the University of Texas System

Inventor： Jay Schneider ,  Jenny Hsieh ,  Douglas Frantz ,  Steven L. McKnight ,  Joseph M. Ready

IPC: C07D413/04 ,  C12N5/079 ,  C07D261/18

CPC classification number: C07D413/04 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  C07C311/49 ,  C07D231/12 ,  C07D261/08 ,  C07D261/18 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C12N5/0618 ,  C12N5/0657 ,  C12N2501/999

Abstract: The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

Abstract translation: 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。