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公开(公告)号：US09221800B2
公开(公告)日：2015-12-29
申请号：US14249846
申请日：2014-04-10
Inventor： Elhadji Dioum , Jay Schneider , Doug Frantz , Hector Aguilar , Melanie Cobb
IPC: C07D413/04 , C07D261/18 , A61K31/415
CPC classification number: C07D413/04 , A61K31/415 , A61K31/42 , A61K31/422 , C07D261/18
Abstract: The present invention relates to compounds and methods for inducing synthesis and secretion of insulin from pancreatic beta cells. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of diabetes.
Abstract translation: 本发明涉及从胰β细胞诱导胰岛素的合成和分泌的化合物和方法。 所述方法可以在体外，离体发生，例如在来自成年哺乳动物组织的分离物中或在体内进行。 本文所述的化合物和方法可用于治疗糖尿病。
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公开(公告)号：US08686012B2
公开(公告)日：2014-04-01
申请号：US13674710
申请日：2012-11-12
Inventor： Eric N. Olson , Douglas Frantz , Jenny Hsieh , Steven L. McKnight , Jay Schneider
IPC: A61K31/4155 , A61K31/422
CPC classification number: C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
Abstract: The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
Abstract translation: 本发明涉及可诱导干细胞分化的化合物的筛选。 此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。
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公开(公告)号：US20140364467A1
公开(公告)日：2014-12-11
申请号：US14310619
申请日：2014-06-20
Inventor： Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
IPC: C07D413/04 , C12N5/079 , C07D261/18
CPC classification number: C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
Abstract: The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
Abstract translation: 本发明涉及在正常神经干细胞和脑癌干细胞中诱导神经元分化的化合物和方法。 该方法可以在体外进行，例如在来自成年哺乳动物脑的分离物中，或在体内。 本文所述的化合物和方法可用于治疗神经变性和精神疾病，神经系统的修复和再生以及治疗神经恶性肿瘤。
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公开(公告)号：US08722716B2
公开(公告)日：2014-05-13
申请号：US13683907
申请日：2012-11-21
Inventor： Elhadij Dioum , Jay Schneider , Doug Frantz , Hector Aguilar , Melanie Cobb
IPC: C07D413/04 , C07D261/18
CPC classification number: C07D413/04 , A61K31/415 , A61K31/42 , A61K31/422 , C07D261/18
Abstract: The present invention relates to compounds and methods for inducing synthesis and secretion of insulin from pancreatic beta cells. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of diabetes.
Abstract translation: 本发明涉及从胰β细胞诱导胰岛素的合成和分泌的化合物和方法。 所述方法可以在体外，离体发生，例如在来自成年哺乳动物组织的分离物中或在体内进行。 本文所述的化合物和方法可用于治疗糖尿病。
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