公开(公告)号：US09523079B2

公开(公告)日：2016-12-20

申请号：US14697955

申请日：2015-04-28

Applicant: The Board of Regents of the University of Texas System

Inventor： Young-Jae Nam ,  Kunhua Song ,  Eric N. Olson

IPC: A61K48/00 ,  C12N5/071 ,  A61P9/00 ,  C12N5/077 ,  C07K14/47 ,  A61K31/7105 ,  A61K38/17 ,  A61K45/06 ,  A61K38/00

CPC classification number: C12N5/0657 ,  A61K31/7105 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K14/4702 ,  C12N2501/40 ,  C12N2770/00043

Abstract: The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.