公开(公告)号：US20180354909A1

公开(公告)日：2018-12-13

申请号：US16060913

申请日：2016-12-09

Applicant: The Board of Regents of the University of Texas System

Inventor： Jef DE BRABANDER ,  Luis F. PARADA ,  S. Kyun LIM ,  Qiren LIANG ,  Hua-yu WANG ,  Yufeng SHI

IPC: C07D235/18 ,  C07D235/16 ,  C07D405/04 ,  C07D401/04 ,  C07D487/04 ,  C07D471/04 ,  A61P35/00

CPC classification number: C07D235/18 ,  A61P35/00 ,  C07D235/16 ,  C07D401/04 ,  C07D405/04 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are compounds of the formula:(I) wherein: R1, R2, R3, R4, R5, X, A1, A2, A3, and A4 are as defined herein. In some aspects, these compounds may be used to treat cancer and other hyperproliferative disease. In some aspects, compositions, methods of treatment, and methods of synthesis are also provided herein.