公开(公告)号：US11333730B2

公开(公告)日：2022-05-17

申请号：US16171255

申请日：2018-10-25

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Manish Saggar

IPC分类号： G01R33/48 ,  G06T7/00 ,  G06T7/50 ,  A61B5/00 ,  G06K9/62 ,  A61B5/16 ,  G01R33/56 ,  A61B5/055 ,  A61B5/369

摘要： Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.

公开(公告)号：US20220365157A1

公开(公告)日：2022-11-17

申请号：US17663654

申请日：2022-05-16

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Manish Saggar

IPC分类号： G01R33/48 ,  G06T7/00 ,  G06T7/50 ,  A61B5/00 ,  G06K9/62 ,  A61B5/16 ,  G01R33/56 ,  A61B5/055

摘要： Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.

公开(公告)号：US11693071B2

公开(公告)日：2023-07-04

申请号：US17663654

申请日：2022-05-16

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Manish Saggar

IPC分类号： G06K9/00 ,  G01R33/48 ,  G06T7/00 ,  G06T7/50 ,  A61B5/00 ,  A61B5/16 ,  G01R33/56 ,  A61B5/055 ,  G06F18/20 ,  G06F18/2323 ,  A61B5/369

CPC分类号： G01R33/4806 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/16 ,  A61B5/165 ,  G01R33/5608 ,  G06F18/2323 ,  G06F18/295 ,  G06T7/0012 ,  G06T7/50 ,  A61B5/369 ,  A61B5/4064 ,  A61B5/7264 ,  A61B5/743 ,  A61B2576/026 ,  G06T2207/10088 ,  G06T2207/30016

摘要： Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.

公开(公告)号：US20230112375A1

公开(公告)日：2023-04-13

申请号：US18045772

申请日：2022-10-11

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Manish Saggar ,  Samir Chowdhury ,  Caleb Geniesse

IPC分类号： G16H30/20

摘要： Embodiments herein describe systems and methods for scalable mapping of brain dynamics and uses thereof are provided. Many embodiments are capable of mapping brain dynamics in a computationally efficient way. In many embodiments, shape graphs can be produced which can operate as interactive network representations of dynamic brain activity data. Methods for automatically interpreting the structure of the shape graphs are described herein. In various embodiments, the mapped brain dynamics can be used to indicate which type of treatment protocol is likely to be most effective for the particular individual. In many embodiments, the treatment includes transcranial magnetic stimulation, pharmaceutical treatment, and/or any other mental condition treatment as appropriate to the requirements of specific applications of embodiments of the invention.

公开(公告)号：US20190120919A1

公开(公告)日：2019-04-25

申请号：US16171255

申请日：2018-10-25

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Manish Saggar

IPC分类号： G01R33/48 ,  G06T7/00 ,  G06T7/50 ,  A61B5/00 ,  G06K9/62 ,  A61B5/055 ,  A61B5/16 ,  G01R33/56

摘要： Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.