公开(公告)号：US20230000869A1

公开(公告)日：2023-01-05

申请号：US17340589

申请日：2021-06-07

申请人： The Brigham and Women's Hospital, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Servic

发明人： Paul B. Yu ,  Wenwei Huang ,  Philip Edward Sanderson ,  Jian-Kang Jiang ,  Khalida Shamim ,  Wei Zheng ,  Xiuli Huang ,  Gregory Tawa ,  Arthur Lee ,  Asaf Alimardanov ,  Junfeng Huang

IPC分类号： A61K31/519 ,  A61P19/08 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/6561

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

公开(公告)号：US20200179389A1

公开(公告)日：2020-06-11

申请号：US16608489

申请日：2018-04-26

申请人： The Brigham and Women's Hospital Inc. ,  The United States of America, as Represented By the Secretary, Deprt. of Health and Human Services

发明人： Paul B. Yu ,  Wenwei Huang ,  Philip Edward Sanderson ,  Jian-Kang Jiang ,  Khalida Shamim ,  Wei Zheng ,  Xiuli Huang ,  Gregory Tawa ,  Arthur Lee ,  Asaf Alimardanov ,  Junfeng Huang

IPC分类号： A61K31/519 ,  A61K45/06 ,  A61P19/08 ,  C07D487/04 ,  C07D519/00 ,  C07F9/6561 ,  A61K31/551 ,  A61K31/5377 ,  A61K31/675

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

公开(公告)号：US11654147B2

公开(公告)日：2023-05-23

申请号：US17340589

申请日：2021-06-07

申请人： The Brigham and Women's Hospital, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： Paul B. Yu ,  Wenwei Huang ,  Philip Edward Sanderson ,  Jian-Kang Jiang ,  Khalida Shamim ,  Wei Zheng ,  Xiuli Huang ,  Gregory Tawa ,  Arthur Lee ,  Asaf Alimardanov ,  Junfeng Huang

IPC分类号： A61K31/519 ,  A61P19/08 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/6561

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  A61P19/08 ,  C07D487/04 ,  C07D519/00 ,  C07F9/6561

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

公开(公告)号：US11026947B2

公开(公告)日：2021-06-08

申请号：US16608489

申请日：2018-04-26

申请人： The Brigham and Women's Hospital, Inc. ,  The United States of America, As Represented By The Secretary, Department Of Health And Human Services

发明人： Paul B. Yu ,  Wenwei Huang ,  Philip Edward Sanderson ,  Jian-Kang Jiang ,  Khalida Shamim ,  Wei Zheng ,  Xiuli Huang ,  Gregory Tawa ,  Arthur Lee ,  Asaf Alimardanov ,  Junfeng Huang

IPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61P19/08 ,  A61K31/675 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/6561

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).