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公开(公告)号：US20210378982A1
公开(公告)日：2021-12-09
申请号：US17277099
申请日：2019-09-24
Applicant: The Cleveland Clinic Foundation
Inventor： Vijay Krishna , Christopher Hine
IPC: A61K31/047 , A23L33/00 , A23L33/125 , A23L33/18 , A23L33/115
Abstract: Provided herein are compositions, systems, kits, and methods for treating a subject with a disease or condition by administering a composition comprising fullerenes to the subject such that H2S is generated in said subject. In certain embodiments, the disease or condition is associated with inflammation and/or below normal H2S levels. In certain embodiments, the fullerenes are polyhydroxy fullerenes (PHFs).
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公开(公告)号：US20200231441A1
公开(公告)日：2020-07-23
申请号：US16483096
申请日：2018-02-02
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Vijay Krishna
IPC: C01B32/156
Abstract: A fullerene-metal nanocomposite is described that comprises a metal nanoparticle bonded to a functionalized fullerene compound. A useful method of making a fullerene-metal nanocomposite is also described. The method consists essentially of the steps of mixing a solution of metal salt or metal ion with a functionalized fullerene compound, and purifying the fullerene-metal nanocomposite from the solution. Also described are antimicrobial surfaces, comprising a substrate surface and a coating on the substrate surface comprising a fullerene-metal nanocomposite that includes a metal nanoparticle bonded to a functionalized fullerene compound.
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公开(公告)号：US20190053991A1
公开(公告)日：2019-02-21
申请号：US16075854
申请日：2017-02-06
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Vijay Krishna , Sanjay Anand , Edward Maytin , Stephen Grobmyer
Abstract: Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation.
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公开(公告)号：US20220233694A1
公开(公告)日：2022-07-28
申请号：US17612115
申请日：2020-05-29
Applicant: The Cleveland Clinic Foundation
Inventor： Vijay Krishna
Abstract: Provided herein are compositions, systems, kits, and methods for administering a gel composition into a tumor of a subject and treating with laser light (e.g., for photoacoustic destruction of the tumor and tumor debris generation), where the gel comprises functionalized fullerenes (FFs) and a biocompatible polymer. In certain embodiments, 0.1-5% (e.g., about 1-2%) by weight of the gel is the functionalized fullerenes (e.g., polyhydroxy fullerenes). In other embodiments, the FFs have a generally symmetrical spherical structure.
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Patent Agency Ranking
公开(公告)号：US20210251860A1
公开(公告)日：2021-08-19
申请号：US17182093
申请日：2021-02-22
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Vijay Krishna , Sanjay Anand , Edward Maytin , Stephen Grobmyer
Abstract: Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation.
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公开(公告)号：US11267708B2
公开(公告)日：2022-03-08
申请号：US16483096
申请日：2018-02-02
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Vijay Krishna
IPC: C01B32/156 , B82Y5/00
Abstract: A fullerene-metal nanocomposite is described that comprises a metal nanoparticle bonded to a functionalized fullerene compound. A useful method of making a fullerene-metal nanocomposite is also described. The method consists essentially of the steps of mixing a solution of metal salt or metal ion with a functionalized fullerene compound, and purifying the fullerene-metal nanocomposite from the solution. Also described are antimicrobial surfaces, comprising a substrate surface and a coating on the substrate surface comprising a fullerene-metal nanocomposite that includes a metal nanoparticle bonded to a functionalized fullerene compound.
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公开(公告)号：US20240277587A1
公开(公告)日：2024-08-22
申请号：US18635154
申请日：2024-04-15
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Vijay Krishna , Sanjay Anand , Edward Maytin , Stephen Grobmyer
CPC classification number: A61K8/19 , A61K8/11 , A61K8/44 , A61Q17/04 , A61K2800/56
Abstract: The complete disclosure of all patents, patent applications, and publications, and electronically available material cited herein are incorporated by reference. The foregoing detailed description and examples have been given for clarity of understanding only. No unnecessary limitations are to be understood therefrom. The invention is not limited to the exact details shown and described, for variations obvious to one skilled in the art will be included within the invention defined by the claims.
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公开(公告)号：US11957769B2
公开(公告)日：2024-04-16
申请号：US17182093
申请日：2021-02-22
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Vijay Krishna , Sanjay Anand , Edward Maytin , Stephen Grobmyer
CPC classification number: A61K8/19 , A61K8/11 , A61K8/44 , A61Q17/04 , A61K2800/56
Abstract: Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation.
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公开(公告)号：US10925817B2
公开(公告)日：2021-02-23
申请号：US16075854
申请日：2017-02-06
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Vijay Krishna , Sanjay Anand , Edward Maytin , Stephen Grobmyer
Abstract: Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation.
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