公开(公告)号：US11350625B2

公开(公告)日：2022-06-07

申请号：US16373203

申请日：2019-04-02

Applicant: The General Hospital Corporation

Inventor： William G. Austen, Jr. ,  Michael C. McCormack ,  Robert W. Redmond ,  Irene E. Kochevar

IPC: A01N1/02 ,  A61F2/06 ,  A61M1/36

Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.

公开(公告)号：US20200078159A1

公开(公告)日：2020-03-12

申请号：US16686691

申请日：2019-11-18

Applicant: The General Hospital Corporation

Inventor： William G. Austen, JR. ,  Michael McCormack ,  Robert W. Redmond ,  Irene E. Kochevar

IPC: A61F2/06 ,  A61N5/06 ,  A61L27/50 ,  A61K41/00 ,  A61L27/54 ,  A61L31/00 ,  A61L27/36 ,  A61L31/16 ,  A61L31/14

Abstract: One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.

公开(公告)号：US20140217649A1

公开(公告)日：2014-08-07

申请号：US14152439

申请日：2014-01-10

Applicant: The General Hospital Corporation

Inventor： Irene E. Kochevar ,  Robert W. Redmond ,  Anne C. O'Neill ,  Mark Randolph

IPC: A61B17/11

CPC classification number: A61B17/1128

Abstract: The present invention relates to a field of biocompatible membranes, tubes and conduits which comprising a photosensitizer which is capable of being crosslinked to form a three dimensional structure which can be implanted into a subject to assist in tissue bonding and nerve maintenance and development. Methods of making such membranes, tubes and conduits and kits comprising them are also described.

Abstract translation: 本发明涉及生物相容性膜，管和导管领域，其包含能够交联以形成三维结构的光敏剂，该三维结构可被植入受试者以辅助组织粘合和神经维持和发育。 还描述了制造这种膜，管和导管以及包括它们的试剂盒的方法。

公开(公告)号：US20210001142A1

公开(公告)日：2021-01-07

申请号：US16781415

申请日：2020-02-04

Applicant: The General Hospital Corporation

Inventor： Michael C. McCormack ,  Robert Redmond ,  William G. Austen ,  Irene E. Kochevar

IPC: A61N5/06

Abstract: One aspect of the invention provides an apparatus including: a fluid-impermeable membrane configured to contain a fluid and be placed in the cavity; a light emitter provided within the membrane; and a fluid provided within the membrane, wherein the fluid scatters light emitted by the light emitter such that the intensity of the light is substantially uniform over the inner surface of the cavity proximal to the membrane.

公开(公告)号：US12208001B2

公开(公告)日：2025-01-28

申请号：US17731805

申请日：2022-04-28

Applicant: The General Hospital Corporation

Inventor： William G. Austen, Jr. ,  Michael McCormack ,  Robert W. Redmond ,  Irene E. Kochevar

IPC: A61F2/06 ,  A61K41/00 ,  A61L27/36 ,  A61L27/50 ,  A61L27/54 ,  A61L31/00 ,  A61L31/14 ,  A61L31/16 ,  A61N5/06

Abstract: A system and a method of preventing or reducing stenosis in a subject is provided. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions, including irradiation with light, sufficient to promote cross-linking of proteins within the vein.

公开(公告)号：US12207648B2

公开(公告)日：2025-01-28

申请号：US17736700

申请日：2022-05-04

Applicant: The General Hospital Corporation

Inventor： William G. Austen, Jr. ,  Michael C. McCormack ,  Robert W. Redmond ,  Irene E. Kochevar

IPC: A61N1/02 ,  A01N1/02 ,  A61F2/06 ,  A61M1/36 ,  A61P9/00

Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.

公开(公告)号：US20220256839A1

公开(公告)日：2022-08-18

申请号：US17736700

申请日：2022-05-04

Applicant: The General Hospital Corporation

Inventor： William G. Austen, JR. ,  Michael C. McCormack ,  Robert W. Redmond ,  Irene E. Kochevar

IPC: A01N1/02 ,  A61F2/06

Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.

公开(公告)号：US10549112B2

公开(公告)日：2020-02-04

申请号：US14849266

申请日：2015-09-09

Applicant: The General Hospital Corporation

Inventor： Michael C. McCormack ,  Robert Redmond ,  William G. Austen, Jr. ,  Irene E. Kochevar

IPC: A61N5/06 ,  A61N5/00

Abstract: One aspect of the invention provides an apparatus including: a fluid-impermeable membrane configured to contain a fluid and be placed in the cavity; a light emitter provided within the membrane; and a fluid provided within the membrane, wherein the fluid scatters light emitted by the light emitter such that the intensity of the light is substantially uniform over the inner surface of the cavity proximal to the membrane.

公开(公告)号：US10478284B2

公开(公告)日：2019-11-19

申请号：US14601023

申请日：2015-01-20

Applicant: The General Hospital Corporation

Inventor： William G. Austen, Jr. ,  Michael McCormack ,  Robert W. Redmond ,  Irene E. Kochevar

IPC: A61F2/06 ,  A61L27/50 ,  A61L27/36 ,  A61L27/54 ,  A61L31/00 ,  A61L31/14 ,  A61L31/16 ,  A61N5/06 ,  A61K41/00

Abstract: Methods of tissue passivation are described herein for use in preserving normal tissue architecture, reducing post-surgical inflammation, and reducing or preventing the development of pathogenic collagen bundles and adhesions following surgical procedures. Passivated tissues prepared in accordance with these methods are useful in a variety of therapies including, e.g., cardiac bypass surgery, hemodialysis, etc.

公开(公告)号：US20160120173A1

公开(公告)日：2016-05-05

申请号：US14992733

申请日：2016-01-11

Applicant: The General Hospital Corporation

Inventor： William G. Austen, JR. ,  Michael McCormack ,  Robert W. Redmond ,  Irene E. Kochevar

IPC: A01N1/02 ,  A61F2/06

CPC classification number: A01N1/0242 ,  A61M1/3655

Abstract: One aspect of the invention provides a vessel treatment system including: a housing defining at least one opening adapted and configured to receive an anatomical vessel; and a humidifier in communication with the housing, the humidifier adapted and configured to introduce humidity into the housing to prevent desiccation of the anatomical vessel. Another aspect of the invention provides a kit including: the vessel treatment system as described herein; and a passivation agent. Another aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; and placing the resected anatomical vessel in a humidified chamber while the tissue passivation agent cures.

Abstract translation: 本发明的一个方面提供了一种血管治疗系统，包括：壳体，其限定适于并构造成容纳解剖血管的至少一个开口; 以及与所述壳体连通的加湿器，所述加湿器适于并构造成将湿度引入所述壳体以防止解剖血管的干燥。 本发明的另一方面提供一种试剂盒，其包括：如本文所述的血管治疗系统; 和钝化剂。 本发明的另一方面提供了一种静脉移植物的制备方法。 该方法包括：将组织钝化剂施加到切除的解剖血管上; 并在组织钝化剂固化时将切除的解剖血管置于加湿室中。