公开(公告)号：US20250012798A1

公开(公告)日：2025-01-09

申请号：US18707478

申请日：2022-11-14

Applicant: The General Hospital Corporation

Inventor： Susan Raju PAUL ,  Mark POZNANSKY ,  Ruxandra F. SIRBULESCU ,  James D. BERRY

IPC: G01N33/569 ,  A61K31/4152 ,  A61K31/428 ,  A61K45/06 ,  G01N15/01

Abstract: The invention features a method including characterizing a white blood cell sample from a patient using cytometry (e.g., CyTOF); wherein a deficiency in regulatory or suppressive immune cells and increased activated immune cells in the sample, relative to a healthy sample, indicates that the patient has amyotrophic lateral sclerosis (ALS).