公开(公告)号：US20250060357A1

公开(公告)日：2025-02-20

申请号：US18937747

申请日：2024-11-05

Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Bo YE ,  Wei LUO ,  Yuan XING ,  Shan YU ,  Qiaoni CHEN

IPC: G01N33/49 ,  G01N15/01 ,  G01N15/14 ,  G06T7/00 ,  G06T7/90 ,  G06V20/69

Abstract: A target cell statistical method, apparatus and system are provided. A cell image of a blood specimen is acquired by a cell image analysis apparatus. The blood specimen is derived from a blood sample to be tested. A number of target cells and a number of reference cells in the cell image are automatically identified by the cell image analysis apparatus. A number of reference cells in the blood sample to be tested is acquired by the cell image analysis apparatus, and a number of target cells in the blood sample to be tested is calculated by the cell image analysis apparatus, based on the number of target cells and the number of reference cells in the cell image and the number of reference cells in the blood sample to be tested.

公开(公告)号：US20250044234A1

公开(公告)日：2025-02-06

申请号：US18747083

申请日：2024-06-18

Applicant: ILLUMINA, INC.

Inventor： Wenyi FENG ,  Simon PRINCE ,  Peter Clarke NEWMAN ,  Dakota WATSON ,  Stanley S. HONG ,  Marco A. KRUMBUEGEL ,  Yinghua SUN ,  Andrew James CARSON ,  Merek C. SIU

IPC: G01N21/85 ,  C12Q1/6869 ,  G01N15/01 ,  G01N15/10 ,  G01N15/1404 ,  G01N15/1434 ,  G01N21/64 ,  G02B7/00

Abstract: A system includes a plurality of modular subassemblies and a plate; wherein each modular subassembly comprises an enclosure and a plurality of optical components aligned to the enclosure, and each enclosure comprises a plurality of mounting structures; and wherein each modular subassembly is mechanically coupled to the plate by attachment of a mounting structure of the modular subassembly directly to a corresponding mounting structure located on the plate, such that by mechanically coupling each modular subassembly to the plate using the mounting structure of the modular subassembly and the corresponding mounting structure on the plate, adjacent modular subassemblies are aligned to each other upon such attachment, and wherein two of the modular subassemblies mechanically coupled to the plate are also attached to each other by mechanically coupling an alignment structure on one of the two modular subassemblies to a respective alignment structure on the other of the two modular subassemblies.

公开(公告)号：US12216033B2

公开(公告)日：2025-02-04

申请号：US18351796

申请日：2023-07-13

Applicant: NOUL CO, LTD.

Inventor： Dongyoung Lee ,  Kyunghwan Kim ,  Youngmin Shin ,  Hyunjeong Yang ,  Chanyang Lim

IPC: G01N1/31 ,  B01L3/00 ,  C07K16/30 ,  C12Q1/6844 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q1/70 ,  G01N1/30 ,  G01N15/06 ,  G01N15/14 ,  G01N21/77 ,  G01N33/483 ,  G01N33/49 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/533 ,  G01N33/574 ,  G01N33/60 ,  G06T7/00 ,  B01L7/00 ,  G01N15/01 ,  G01N15/075

Abstract: The present disclosure relates to a gel-phase patch that performs a function of assisting in staining during a staining process such as a process of coming into contact with a specimen such as blood to perform a staining function of staining the specimen, a process of fixing the specimen, or a process of forming an optimal pH at a specimen stained by a staining sample. According to an aspect of the present disclosure, a contact-type staining patch includes a staining solution that reacts with a specimen and a gel receptor provided as a gel matrix of a mesh structure in which a pore that accommodates the staining solution is formed and the mesh structure prevents the staining solution in the pore from leaking or degenerating, and having a contact surface that comes into contact with the specimen to transfer some of the staining solution to the specimen.

公开(公告)号：US20250034655A1

公开(公告)日：2025-01-30

申请号：US18782873

申请日：2024-07-24

Applicant: Michael CHRISTENSEN

Inventor： Michael CHRISTENSEN

IPC: C12Q1/6888 ,  C12N5/071 ,  G01N15/01 ,  G16H10/40

Abstract: Described herein are methods and systems for selecting and analyzing sperm cells. In particular, described herein are methods and systems for isolating bicephalic sperm cells and performing genomic analysis on the same while maintaining the viability of the sperm cell for implantation. Such systems and methods may be used in, for example, assisted reproduction and animal breeding applications.

公开(公告)号：US20250020574A1

公开(公告)日：2025-01-16

申请号：US18887450

申请日：2024-09-17

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Kalyan Handique ,  Austin Payne ,  Vishal Sharma ,  Kyle Gleason ,  Priyadarshini Gogoi ,  Karthik Ganesan ,  Brian Boniface ,  Will Chow

IPC: G01N15/14 ,  B01L3/00 ,  B01L3/02 ,  C12M1/00 ,  G01N1/20 ,  G01N1/28 ,  G01N1/40 ,  G01N15/01 ,  G01N15/10 ,  G01N15/1433 ,  G01N15/149 ,  G01N35/00 ,  G01N35/10 ,  G06V10/141 ,  G06V10/145 ,  G06V10/147 ,  G06V20/69

Abstract: A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.

公开(公告)号：US12196662B2

公开(公告)日：2025-01-14

申请号：US17606101

申请日：2020-04-24

Applicant: HORIBA ABX SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE MONTPELLIER

Inventor： Pierre Taraconat ,  Damien Isebe ,  Simon Mendez ,  Franck Nicoud

IPC: G01N15/12 ,  G01N15/01

Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

公开(公告)号：US20250012695A1

公开(公告)日：2025-01-09

申请号：US18761564

申请日：2024-07-02

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Qing Xia

IPC: G01N15/01 ,  G01N15/1434

Abstract: A wide-field microscopy system and method for imaging a sample include directing infrared light onto the sample to selectively heat the sample. Probe light is also directed onto the sample. An objective collects the probe light after it interacts with the sample. The collected probe light is detected at a detector. A relative distance between the objective and sample is adjusted to introduce an optical defocus enhancement to enhance detection of a change in detected probe light that is indicative of infrared absorption by the sample.

公开(公告)号：US20250003859A1

公开(公告)日：2025-01-02

申请号：US18756372

申请日：2024-06-27

Applicant: Life Technologies Corporation

Inventor： Samuel Henry Adler Rudy ,  Daniel Nelson Fox ,  Nicholas John Rohrbacker

IPC: G01N15/1429 ,  G01N15/01 ,  G01N15/10 ,  G01N15/149

Abstract: Disclosed herein are apparatuses, systems, as well as related methods, computing devices, and computer-readable media related to real time cell sorter cell sorting using embeddings. For example, in some embodiments a method may comprise receiving first cell sorter data. The first cell sorter data may include cell sorter data including microscopy data, hyperspectral imaging data, high-dimensional vector data, or one or more combinations thereof. In some embodiments, the cell sorter data may include quantitative fluorescence data expressed as one or more of antibodies bound per cell, antibody binding capacity (ABC), molecules of equivalent soluble fluorochrome (MESF), one or more other quantitative indicators of fluorescence, or one or more combinations thereof. In some embodiments, the quantitative fluorescence data includes one or more fluorescence signals from: one or more fluorescent proteins, one or more fluorescent dyes, one or more fluorescently conjugate antibodies, or one or more combinations thereof.

公开(公告)号：US12181463B2

公开(公告)日：2024-12-31

申请号：US17360503

申请日：2021-06-28

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Amir Zait ,  Arnon Houri Yafin ,  Dan Gluck ,  Sharon Pecker ,  Yochay Shlomo Eshel ,  Sarah Levy Schreier ,  Joseph Joel Pollak

IPC: G01N33/50 ,  G01N15/06 ,  G01N33/49 ,  G01N33/569 ,  G01N33/72 ,  G01N15/01

Abstract: Apparatus and methods are described including measuring hematocrit within a blood sample, by performing a first measurement on a first portion of the blood sample. Mean corpuscular volume in the blood sample is measured, by performing a second measurement on a second portion of the blood sample, the second portion being diluted with respect to the first portion. A red blood cell count per unit volume within the blood sample is determined by dividing the hematocrit measured within the first portion by the mean corpuscular volume measured within the second portion. Other applications are also described.

公开(公告)号：US20240418627A1

公开(公告)日：2024-12-19

申请号：US18708291

申请日：2021-11-09

Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

Inventor： Vahid SANDOGHDAR ,  Martin BLESSING ,  Anna D. KASHKANOVA ,  Andre GEMEINHARDT

IPC: G01N15/1433 ,  G01N15/00 ,  G01N15/01 ,  G01N15/14 ,  G01N15/1434

Abstract: A method of determining nanoparticle properties of nanoparticles (2) included in a sample (1), comprising the steps of collecting sequential frames of images by employing an interferometric microscope device (110), wherein the sample (1) is illuminated with illumination light (3) from a coherent light source device (111) and the images are created by scattering light (4) from the nanoparticles (2) superimposed with non-scattered reference light, said scattering light and reference light having a wavelength larger than a cross-sectional dimension of the nanoparticles (2), tracking the nanoparticles (2) in the sequential frames of images, wherein at least one interferometric point spread function (iPSF) feature of each of the nanoparticles (2) is established and nanoparticle trajectory motion data are determined for each nanoparticle (2), comprising the nanoparticle positions in each frame, for each nanoparticle (2), calculating a nanoparticle size d from the trajectory motion data of the nanoparticle and calculating an interferometric nanoparticle contrast from the at least one iPSF feature of the nanoparticle.