公开(公告)号：US20220273768A1

公开(公告)日：2022-09-01

申请号：US17747905

申请日：2022-05-18

申请人： The George Washington University ,  Johns Hopkins University, School of Medicine

发明人： David MENDELOWITZ ,  Vsevolod POLOTSKY ,  Carla FREIRE

IPC分类号： A61K38/22 ,  A61P25/04

摘要： The present disclosure generally relates to compositions and methods of treating opioid-induced respiratory depression in a subject in need thereof, the method comprising administering leptin.

公开(公告)号：US20210322510A1

公开(公告)日：2021-10-21

申请号：US16951048

申请日：2020-11-18

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： David MENDELOWITZ ,  Vivek JAIN ,  Heather JAMESON ,  Jay Shawn KIMBRO

IPC分类号： A61K38/095 ,  A61K9/00

摘要： The present disclosure provides methods for treating obstructive sleep apnea (OSA) and OSA induced cardiorespiratory diseases. The disclosure provides, inter alia, methods for treating or alleviating: OSA or OSA induced hypertension, cardiac arrhythmias, myocardial ischemia, sudden cardiac death or stroke, by administering oxytocin. The disclosure further provides methods for improving sleep satisfaction in OSA patients by administering oxytocin.

公开(公告)号：US20190076501A1

公开(公告)日：2019-03-14

申请号：US16184091

申请日：2018-11-08

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： David MENDELOWITZ ,  Vivek JAIN ,  Heather JAMESON ,  Jay Shawn KIMBRO

IPC分类号： A61K38/11 ,  A61K9/00

摘要： The present disclosure provides methods for treating obstructive sleep apnea (OSA) and OSA induced cardiorespiratory diseases. The disclosure provides, inter alia, methods for treating or alleviating: OSA or OSA induced hypertension, cardiac arrhythmias, myocardial ischemia, sudden cardiac death or stroke, by administering oxytocin. The disclosure further provides methods for improving sleep satisfaction in OSA patients by administering oxytocin.