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公开(公告)号：US20230340524A1
公开(公告)日：2023-10-26
申请号：US18015042
申请日：2021-07-07
IPC分类号： C12N15/85 , A01K67/027 , C12N9/22 , C12N15/11 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/535
CPC分类号： C12N15/8509 , A01K67/027 , C12N9/22 , C12N15/11 , C07K14/52 , C07K14/5412 , C07K14/70578 , C07K14/535 , C12N2015/8536 , A01K2267/0362 , A01K2227/105 , A01K2217/07 , C12N2310/20
摘要： The present disclosure provides immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG™) mouse models that comprise an inactivated mouse Flt3 allele and, in some models, additional genetic modifications. These mouse models useful, for example, for superior engraftment of diverse hematopoietic lineages and for immune-oncology, immunology and infectious disease studies.
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公开(公告)号：US11674187B2
公开(公告)日：2023-06-13
申请号：US17253974
申请日：2019-06-28
发明人： Jacques Banchereau , Diogo Fernando Troggian Veiga , Anne Deslattes Mays , Saman Zeeshan , Anna Karolina Palucka
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Provided herein, in some embodiments, are methods, compositions, and systems for identifying alternatively spliced tumor-specific exon inclusion and exclusion events that can be used for survival prognosis.
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公开(公告)号：US20190082664A1
公开(公告)日：2019-03-21
申请号：US16131256
申请日：2018-09-14
IPC分类号： A01K67/027 , G01N33/50
摘要： The present disclosure provides, in some aspects, a humanized mouse (NSG™-SGM3), engrafted with CD34+ hematopoietic progenitor cells and human metastatic melanoma cells, which surprisingly promotes secondary metastatic colonization, modeling the interplay between human tumors and the human immune system, and thus enabling mechanistic and pre-clinical studies for the development of novel treatment strategies targeting human-specific molecular pathways controlling melanoma dissemination.
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公开(公告)号：US20230270085A1
公开(公告)日：2023-08-31
申请号：US18015043
申请日：2021-07-07
IPC分类号： A01K67/027 , C07K14/54 , C07K14/535 , C07K14/74 , C12N15/85
CPC分类号： A01K67/0275 , C07K14/5403 , C07K14/535 , C07K14/70539 , C12N15/8509 , A01K2207/15 , A01K2217/075 , A01K2227/105 , A01K2267/0362 , A01K2267/0387 , A01K2217/072
摘要： The present disclosure provides an immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG™) mouse models that comprise an inactivated mouse Flt3 allele, a nucleic acid encoding human interleukin 3 (IL3), a nucleic acid encoding human granulocyte/macrophage-stimulating factor (GM-CSF), a nucleic acid encoding human stem cell factor (SCF), and a HLA-A2/H2-D/B2M transgene encoding (i) a human B2-microglubulin (B2M) covalently linked to MHC class 1, alpha 1, and alpha2 binding domains of a human HLA-A2.1 gene and (ii) alpha3 cytoplasmic and transmembrane domains of murine H2-db.
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公开(公告)号：US20210254176A1
公开(公告)日：2021-08-19
申请号：US17253974
申请日：2019-06-28
发明人： Jacques Banchereau , Diogo Fernando Troggian Veiga , Anne Deslattes Mays , Saman Zeeshan , Anna Karolina Palucka
IPC分类号： C12Q1/6886
摘要： Provided herein, in some embodiments, are methods, compositions, and systems for identifying alternatively spliced tumor-specific exon inclusion and exclusion events that can be used for survival prognosis.
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公开(公告)号：US20210233640A1
公开(公告)日：2021-07-29
申请号：US17256256
申请日：2019-06-26
IPC分类号： G16H20/40
摘要： Methods and apparatus for identifying alternative splicing events. The method comprises receiving a dataset of percent spliced in (PSI) values for each of a plurality of biological samples, wherein the plurality of biological samples includes a first population of samples having a first characteristic and a second population of samples having a second characteristic different from the first characteristic, fitting, to the dataset, a probabilistic model to identify clusters of samples in the dataset, calculating cluster characteristics for each of the clusters, filtering the clusters based, at least in part, on the cluster characteristics to identify a subset of clusters, each of which is associated with an alternative splicing event, and storing on the at least one storage device, information associated with the identified alternative splicing events.
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公开(公告)号：US12051496B2
公开(公告)日：2024-07-30
申请号：US17256256
申请日：2019-06-26
IPC分类号： G16H20/40
CPC分类号： G16H20/40
摘要： Methods and apparatus for identifying alternative splicing events. The method comprises receiving a dataset of percent spliced in (PS I) values for each of a plurality of biological samples, wherein the plurality of biological samples includes a first population of samples having a first characteristic and a second population of samples having a second characteristic different from the first characteristic, fitting, to the dataset, a probabilistic model to identify clusters of samples in the dataset, calculating cluster characteristics for each of the clusters, filtering the clusters based, at least in part, on the cluster characteristics to identify a subset of clusters, each of which is associated with an alternative splicing event, and storing on the at least one storage device, information associated with the identified alternative splicing events.
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公开(公告)号：US20230374608A1
公开(公告)日：2023-11-23
申请号：US18302737
申请日：2023-04-18
发明人： Jacques Banchereau , Diogo Fremando Troggian Veiga , Anne Deslattes Mays , Saman Zeeshan , Anna Karolina Palucka
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Provided herein, in some embodiments, are methods, compositions, and systems for identifying alternatively spliced tumor-specific exon inclusion and exclusion events that can be used for survival prognosis.
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