公开(公告)号：US20230389926A1

公开(公告)日：2023-12-07

申请号：US18249186

申请日：2021-10-14

申请人： The Johns Hopkins University

发明人： Hai-Quan Mao ,  Sami Tuffaha ,  Ahmet Hoke ,  Michael James Lan ,  Bruce Peter Enzmann ,  Anson Y. Zhou ,  Alison L. Wong ,  Erica Lee ,  Sai Pinni

IPC分类号： A61B17/11 ,  A61L27/52

CPC分类号： A61B17/1128 ,  A61B2017/00893 ,  A61L27/52

摘要： Biodegradable nanofiber conical conduits for nerve repair and methods of using same are disclosed. The biodegradable nanofiber conical conduits for nerve repair and methods provide a saturable conduit having a conical shape/geometry including a larger proximal aperture and smaller distal aperture to mechanically guide the regenerating axons across the mismatched repair and thereby prevent axonal escape and neuroma formation. The biodegradable nanofiber conical conduits for nerve repair may include, but are not limited to, a conical conduit that tapers substantially linearly; a conical conduit including a conical concave shape, a conical conduit including a conical convex shape, a conical conduit including proximal and/or distal extensions, a conical conduit including an arrangement of lateral or radial ridges for crimping action, and a conical conduit filled with hydrogel for inhibiting excessive axonal growth.

公开(公告)号：US20230181340A1

公开(公告)日：2023-06-15

申请号：US17926507

申请日：2021-05-25

申请人： The Johns Hopkins University

发明人： Connor Glass ,  Nitish V. Thakor ,  Sami Tuffaha ,  Alexis Lowe

IPC分类号： A61F2/72 ,  A61B5/389 ,  A61B5/313 ,  A61B5/00

CPC分类号： A61F2/72 ,  A61B5/389 ,  A61B5/313 ,  A61B5/0031 ,  A61F2002/705

摘要： An implantable human-machine interfacing system is disclosed that includes an implantable muscle interface device including a substrate including a first plurality of sensors and a second plurality of amplifiers that capture and amplify, respectively, electromyographic (EMG) signals arising from motor units under control of neural signals representative of volitional limb movements; and a transceiver device connected to the first plurality of sensors that wirelessly transmits signals to an external decoder that produces decoded signals that discriminate motor signals representative of movements of the motor units, wherein the substrate at least partially surrounds a muscle from which the EMG signals arise; and a receiver device that uses the decoded signals for interaction with an external system. The system includes a first plurality of electrodes and a second implantable power source that imparts electrical stimulation to the underlying tissues and sensory axons within for the purposes of sensory feedback and neuromodulation.