公开(公告)号：US10039530B2

公开(公告)日：2018-08-07

申请号：US14973823

申请日：2015-12-18

申请人： The Johns Hopkins University

发明人： Russell H. Taylor ,  Iulian Iordachita ,  Jin U. Kang ,  Xuan Liu

IPC分类号： A61B17/00 ,  A61F9/007 ,  A61B19/00 ,  A61B17/34 ,  A61B17/30 ,  G01J3/26 ,  A61B90/00 ,  A61B34/20

摘要： A surgical tool system according to an embodiment of the current invention includes a surgical tool, and an interferometry system optically coupled to the surgical tool. The surgical tool includes a body section, a sensor section at least one of attached to or integral with the body section, and a surgical section at least one of attached to or integral with the sensor section at an opposing end of the sensor section from the body section. The sensor section comprises an interferometric optical sensor defining a reference distance that changes in response to at least one of a force or a torque when applied to the surgical section of the surgical tool.

公开(公告)号：US20150354939A1

公开(公告)日：2015-12-10

申请号：US14299968

申请日：2014-06-09

申请人： The Johns Hopkins University

发明人： Xuan Liu ,  Jin U. Kang

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B9/0203

摘要： An optical coherence tomography (OCT) system having magnitude and direction of motion detection has a light source, and a scanning system arranged in an optical path of the light source. The scanning system is configured to scan an illumination beam of light in a spatial pattern around each of a plurality of points of interest of an object under observation for a corresponding plurality of instants of time in which each of the plurality of points of interest are displaced from each other due to motion of at least one of the OCT system or the object under observation. The OCT system also includes an OCT detection system configured and arranged to receive at least a portion of the illumination beam of light after being at least one of reflected or scattered from said the under observation, and a signal processor configured to communicate with the OCT detection system to receive detection signals therefrom. The signal processor is configured to process the detection signals to determine both magnitude and direction of relative motion of the OCT system from a first one of the plurality of points at a first corresponding time to a second one of the plurality of points at a second corresponding time.

摘要翻译： 具有运动检测的大小和方向的光学相干断层摄影（OCT）系统具有光源和布置在光源的光路中的扫描系统。 扫描系统被配置成扫描围绕观察对象的多个感兴趣点的每一个的空间模式的照明光束，用于相应的多个时刻，其中多个感兴趣点中的每一个都被移位 由于OCT系统或观察对象中的至少一个的运动而彼此相关。 OCT系统还包括OCT检测系统，其配置和布置成在从所述下观察中反射或散射中的至少一个之后接收所述照明光束的至少一部分，以及被配置为与OCT检测通信的信号处理器 系统从其接收检测信号。 所述信号处理器被配置为处理所述检测信号以确定所述OCT系统的大小和相对运动的方向与所述多个点中的第一点在第一对应时间到所述多个点中的第二点处的第二对应点处的第二对应 时间。

公开(公告)号：US20140160462A1

公开(公告)日：2014-06-12

申请号：US13709874

申请日：2012-12-10

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Jin U. KANG ,  Xuan Liu

IPC分类号： G01P5/26

CPC分类号： G01P5/26

摘要： A system for assessing the flow of a fluid. The system can include a light source, a fiber-optic system optically coupled to the light source, which is arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system to receive the detection signals. The data processing system can be configured to use the detection signals to determine a speckle pattern corresponding to the fluid flow, wherein the speckle pattern includes a plurality of lines, and to calculate a correlation between adjacent lines perpendicular to the flow to determine at least one of a rate of the flow and a displacement of the flow.

摘要翻译： 用于评估流体流动的系统。 该系统可以包括光源，光耦合到光源的光纤系统，其被布置成提供参考光束和观察光束;光学检测系统，布置成接收来自参考光束和观察光束的组合光 并提供检测信号，以及数据处理系统，被配置为与光学检测系统通信以接收检测信号。 数据处理系统可以被配置为使用检测信号来确定与流体流动相对应的散斑图案，其中散斑图案包括多条线，并且计算垂直于流动的相邻线之间的相关性，以确定至少一个 的流量和流量的位移。

公开(公告)号：US09243887B2

公开(公告)日：2016-01-26

申请号：US13734715

申请日：2013-01-04

申请人： The Johns Hopkins University

发明人： Jin U. Kang ,  Xuan Liu

IPC分类号： G01B9/02 ,  A61B5/00

CPC分类号： G01B9/02091 ,  A61B5/0066 ,  G01B9/02044 ,  G01B9/0207 ,  G01B9/02072 ,  G01B2290/65

摘要： A lateral-distortion corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system and receive the detection signals. The data processing system can be configured to assemble an image corresponding to a scanning path by constructing a plurality of A-scans from the detection signals, determining displacement information from the plurality of A-scans, and arranging the plurality of A-scans according to the displacement information.

摘要翻译： 横向失真校正光学相干断层扫描系统。 所述系统可以包括光学相干断层摄影传感器，光源，布置成提供参考光束和观察光束的光纤系统;光学检测系统，布置成接收来自参考光束和观察光束的组合光，并提供 检测信号，以及被配置为与光学检测系统通信并接收检测信号的数据处理系统。 数据处理系统可以被配置为通过从检测信号构造多个A扫描来组合对应于扫描路径的图像，确定来自多个A扫描的位移信息，以及根据 位移信息。

公开(公告)号：US09207062B2

公开(公告)日：2015-12-08

申请号：US13709885

申请日：2012-12-10

申请人： The Johns Hopkins University

发明人： Jin U. Kang ,  Xuan Liu

IPC分类号： G01B9/02 ,  A61B5/00

CPC分类号： G01B9/02045 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/0207 ,  G01B9/02077 ,  G01B9/02091

摘要： An axial motion distortion-corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to receive said detection signals, construct a plurality of A-scans from said detection signals, and construct one or more images from said plurality of A-scans. The data processing system can be configured to correct distortion in the images caused by net axial motion of at least one of said optical coherence tomography sensor or a target of said optical coherence tomography sensor by calculating an estimate of the net axial motion using Doppler shift, and then shifting the A-scans according to the estimate.

摘要翻译： 轴向运动失真校正光学相干断层扫描系统。 所述系统可以包括光学相干断层摄影传感器，光源，布置成提供参考光束和观察光束的光纤系统;光学检测系统，布置成接收来自参考光束和观察光束的组合光，并提供 检测信号和被配置为接收所述检测信号的数据处理系统，从所述检测信号构建多个A扫描，并从所述多个A扫描构造一个或多个图像。 数据处理系统可以被配置为通过使用多普勒频移计算净轴向运动的估计来校正由所述光学相干断层摄影传感器或所述光学相干断层摄影传感器的目标中的至少一个的净轴向运动引起的图像中的失真， 然后根据估计移动A扫描。

公开(公告)号：US20140160484A1

公开(公告)日：2014-06-12

申请号：US13709885

申请日：2012-12-10

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Jin U. KANG ,  Xuan Liu

IPC分类号： G01B9/02

CPC分类号： G01B9/02045 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/0207 ,  G01B9/02077 ,  G01B9/02091

摘要： An axial motion distortion-corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to receive said detection signals, construct a plurality of A-scans from said detection signals, and construct one or more images from said plurality of A-scans. The data processing system can be configured to correct distortion in the images caused by net axial motion of at least one of said optical coherence tomography sensor or a target of said optical coherence tomography sensor by calculating an estimate of the net axial motion using Doppler shift, and then shifting the A-scans according to the estimate.

摘要翻译： 轴向运动失真校正光学相干断层扫描系统。 所述系统可以包括光学相干断层摄影传感器，光源，布置成提供参考光束和观察光束的光纤系统;光学检测系统，布置成接收来自参考光束和观察光束的组合光，并提供 检测信号和被配置为接收所述检测信号的数据处理系统，从所述检测信号构建多个A扫描，并从所述多个A扫描构造一个或多个图像。 数据处理系统可以被配置为通过使用多普勒频移计算净轴向运动的估计来校正由所述光学相干断层摄影传感器或所述光学相干断层摄影传感器的目标中的至少一个的净轴向运动引起的图像中的失真， 然后根据估计移动A扫描。

公开(公告)号：US09506741B2

公开(公告)日：2016-11-29

申请号：US14299968

申请日：2014-06-09

申请人： The Johns Hopkins University

发明人： Xuan Liu ,  Jin U. Kang

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B9/0203

摘要： An optical coherence tomography (OCT) system having magnitude and direction of motion detection has a light source, and a scanning system arranged in an optical path of the light source. The scanning system is configured to scan an illumination beam of light in a spatial pattern around each of a plurality of points of interest of an object under observation for a corresponding plurality of instants of time in which each of the plurality of points of interest are displaced from each other due to motion of at least one of the OCT system or the object under observation. The OCT system also includes an OCT detection system configured and arranged to receive at least a portion of the illumination beam of light after being at least one of reflected or scattered from said the under observation, and a signal processor configured to communicate with the OCT detection system to receive detection signals therefrom. The signal processor is configured to process the detection signals to determine both magnitude and direction of relative motion of the OCT system from a first one of the plurality of points at a first corresponding time to a second one of the plurality of points at a second corresponding time.

摘要翻译： 具有运动检测的大小和方向的光学相干断层摄影（OCT）系统具有光源和布置在光源的光路中的扫描系统。 扫描系统被配置成扫描围绕观察对象的多个感兴趣点的每一个的空间模式的照明光束，用于相应的多个时刻，其中多个感兴趣点中的每一个都被移位 由于OCT系统或观察对象中的至少一个的运动而彼此相关。 OCT系统还包括OCT检测系统，其配置和布置成在从所述下观察中反射或散射中的至少一个之后接收所述照明光束的至少一部分，以及被配置为与所述OCT检测通信的信号处理器 系统从其接收检测信号。 所述信号处理器被配置为处理所述检测信号以确定所述OCT系统的大小和相对运动的方向与所述多个点中的第一点在第一对应时间到所述多个点中的第二点在第二对应 时间。

公开(公告)号：US09175944B2

公开(公告)日：2015-11-03

申请号：US13709958

申请日：2012-12-10

申请人： The Johns Hopkins University

发明人： Jin U. Kang ,  Xuan Liu

IPC分类号： G01B9/02 ,  A61B3/10 ,  A61B5/00 ,  G02B6/10 ,  G02B6/06

CPC分类号： G01B9/02052 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/06 ,  G02B6/10 ,  Y10T156/108

摘要： A probe for a common path optical coherence tomography system includes a sheath having a proximal end and a distal end and defining a lumen therein, a single mode optical fiber disposed within the lumen of the sheath such that a portion of the single mode optical fiber extends beyond the distal end of the sheath. The single mode optical fiber has an end face for transmitting and receiving light. The probe also includes a layer of hardened epoxy encasing the portion of the single mode optical fiber that extends beyond the distal end of the sheath except for the end face. The single mode optical fiber has an optical axis extending along a longitudinal direction of the single mode optical fiber. The hardened epoxy is polished at a non-orthogonal angle relative to the optical axis at the end face.

摘要翻译： 用于共同路径光学相干断层摄影系统的探针包括具有近端和远端并且在其中限定内腔的护套，设置在护套的内腔内的单模光纤，使得单模光纤的一部分延伸 超出护套的远端。 单模光纤具有用于发送和接收光的端面。 该探针还包括一层硬化的环氧树脂，其包围单模光纤的除了端面之外延伸超过护套的远端的部分。 单模光纤具有沿着单模光纤的纵向延伸的光轴。 硬化的环氧树脂在端面处以相对于光轴的非正交角度抛光。

公开(公告)号：US20130188196A1

公开(公告)日：2013-07-25

申请号：US13734715

申请日：2013-01-04

申请人： The Johns Hopkins University

发明人： Jin U. Kang ,  Xuan Liu

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  A61B5/0066 ,  G01B9/02044 ,  G01B9/0207 ,  G01B9/02072 ,  G01B2290/65

摘要： A lateral-distortion corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system and receive the detection signals. The data processing system can be configured to assemble an image corresponding to a scanning path by constructing a plurality of A-scans from the detection signals, determining displacement information from the plurality of A-scans, and arranging the plurality of A-scans according to the displacement information.

摘要翻译： 横向失真校正光学相干断层扫描系统。 所述系统可以包括光学相干断层摄影传感器，光源，布置成提供参考光束和观察光束的光纤系统;光学检测系统，布置成接收来自参考光束和观察光束的组合光，并提供 检测信号，以及被配置为与光学检测系统通信并接收检测信号的数据处理系统。 数据处理系统可以被配置为通过从检测信号构造多个A扫描来组合对应于扫描路径的图像，确定来自多个A扫描的位移信息，以及根据 位移信息。

公开(公告)号：US08964170B2

公开(公告)日：2015-02-24

申请号：US13709874

申请日：2012-12-10

申请人： The Johns Hopkins University

发明人： Jin U. Kang ,  Xuan Liu

IPC分类号： G01P5/26

CPC分类号： G01P5/26

摘要： A system for assessing the flow of a fluid. The system can include a light source, a fiber-optic system optically coupled to the light source, which is arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system to receive the detection signals. The data processing system can be configured to use the detection signals to determine a speckle pattern corresponding to the fluid flow, wherein the speckle pattern includes a plurality of lines, and to calculate a correlation between adjacent lines perpendicular to the flow to determine at least one of a rate of the flow and a displacement of the flow.

摘要翻译： 用于评估流体流动的系统。 该系统可以包括光源，光耦合到光源的光纤系统，其被布置成提供参考光束和观察光束;光学检测系统，布置成接收来自参考光束和观察光束的组合光 并提供检测信号，以及数据处理系统，被配置为与光学检测系统通信以接收检测信号。 数据处理系统可以被配置为使用检测信号来确定与流体流动相对应的散斑图案，其中斑点图案包括多条线，并且计算垂直于流动的相邻线之间的相关性，以确定至少一个 的流量和流量的位移。