公开(公告)号：US11001809B2

公开(公告)日：2021-05-11

申请号：US15036235

申请日：2014-11-13

申请人： THE MCLEAN HOSPITAL CORPORATION

发明人： Kwang-Soo Kim ,  Young Cha

IPC分类号： C12N5/074 ,  C12N15/113 ,  A61K35/12

摘要： Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells, contacting the contacting the somatic or non-embryonic cells with a quantity of one or more reprogramming factors and one or more RNA molecules, and culturing the somatic or non-embryonic cells for a period of time sufficient to generate at least one induced pluripotent stem cell. Various reprogramming factors and RNA molecules for use in the methods are disclosed herein. Also disclosed are cell lines and pharmaceutical compositions generated by use of the methods.

公开(公告)号：US20240132852A1

公开(公告)日：2024-04-25

申请号：US18400671

申请日：2023-12-29

申请人： The McLean Hospital Corporation

发明人： Kwang-Soo Kim ,  Young Cha

IPC分类号： C12N5/074 ,  A61K35/12 ,  C12N15/113

CPC分类号： C12N5/0696 ,  A61K35/12 ,  C12N15/113 ,  C12N2310/141 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/65 ,  C12N2506/1307 ,  C12N2510/00 ,  C12N2799/022

摘要： Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells, contacting the contacting the somatic or non-embryonic cells with a quantity of one or more programming factors and one or more RNA molecules, and culturing the somatic or non-embryonic cells for a period of time sufficient to generate at least one induced pluripotent stem cell. Various reprogramming factors and RNA molecules for use in the methods are disclosed herein. Also disclosed are cell lines and pharmaceutical compositions generated by use of the methods.

公开(公告)号：US20210238556A1

公开(公告)日：2021-08-05

申请号：US17239059

申请日：2021-04-23

申请人： The McLean Hospital Corporation

发明人： Kwang-Soo Kim ,  Young Cha

IPC分类号： C12N5/074 ,  C12N15/113 ,  A61K35/12

摘要： Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells, contacting the contacting the somatic or non-embryonic cells with a quantity of one or more programming factors and one or more RNA molecules, and culturing the somatic or non-embryonic cells for a period of time sufficient to generate at least one induced pluripotent stem cell. Various reprogramming factors and RNA molecules for use in the methods are disclosed herein. Also disclosed are cell lines and pharmaceutical compositions generated by use of the methods.

公开(公告)号：US11898169B2

公开(公告)日：2024-02-13

申请号：US17239059

申请日：2021-04-23

申请人： The McLean Hospital Corporation

发明人： Kwang-Soo Kim ,  Young Cha

IPC分类号： C12N5/074 ,  C12N15/113 ,  A61K35/12

CPC分类号： C12N5/0696 ,  A61K35/12 ,  C12N15/113 ,  C12N2310/141 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/65 ,  C12N2506/1307 ,  C12N2510/00 ,  C12N2799/022 ,  C12N2310/141 ,  C12N2330/10

摘要： Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells, contacting the contacting the somatic or non-embryonic cells with a quantity of one or more programming factors and one or more RNA molecules, and culturing the somatic or non-embryonic cells for a period of time sufficient to generate at least one induced pluripotent stem cell. Various reprogramming factors and RNA molecules for use in the methods are disclosed herein. Also disclosed are cell lines and pharmaceutical compositions generated by use of the methods.