公开(公告)号：US20030163003A1

公开(公告)日：2003-08-28

申请号：US10319093

申请日：2002-12-13

Applicant: The Penn State Research Foundation

Inventor： Xumu Zhang ,  Dengming Xiao

IPC: C07C29/52 ,  C07F009/28 ,  C07F009/02 ,  C07F015/00

CPC classification number: C07C45/505 ,  B01J31/2419 ,  B01J2231/643 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2531/56 ,  B01J2531/66 ,  B01J2531/72 ,  B01J2531/74 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  C07B53/00 ,  C07C39/17 ,  C07C45/69 ,  C07C45/72 ,  C07C209/52 ,  C07D213/04 ,  C07F9/005 ,  C07F9/5027 ,  C07F9/58 ,  C07F9/60 ,  C07F9/65683 ,  C07F11/005 ,  C07F13/005 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0046 ,  C07F15/0053 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/0073 ,  C07F15/008 ,  C07F15/0086 ,  C07F15/0093 ,  C07F17/02

Abstract: Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include phospholanes, P,N ligands, N,N ligands, biphenols, and chelating phosphines. The ferrocene-based irridium (R,R)-f-binaphane complex reduces imines to the corresponding amines with 95-99.6% enantioselectivity and reduces null-substituted-null-arylenamides with 95% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation of imines, asymmetric hydride transfer reactions, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.