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    Method For Preparing 3-Aminomethyl-3,5,5-Trimethyl Cyclohexylamine
    4.
    发明申请
    Method For Preparing 3-Aminomethyl-3,5,5-Trimethyl Cyclohexylamine 有权
    3-氨基甲基-3,5,5-三甲基环己胺的制备方法

    公开(公告)号：US20150315133A1

    公开(公告)日：2015-11-05

    申请号：US14648533

    申请日：2012-12-07

    申请人： WANHUA CHEMICAL GROUP CO., LTD. ,  WANHUA CHEMICAL (NINGBO) CO., LTD.

    发明人： Changsheng Chen ,  Jinke Jiang ,  Zhongying Chen ,  Jiaoying Cui ,  Jing Wang ,  Fuguo Li ,  Chengge Lv ,  Wenjuan Zhao ,  Yuan Li ,  Weiqi Hua

    IPC分类号： C07C253/30 ,  C07C209/52

    CPC分类号： C07C253/30 ,  C07C209/48 ,  C07C209/52 ,  C07C2101/14 ,  C07C2601/14 ,  C07C255/46 ,  C07C211/36

    摘要： The present invention provides a method for preparing 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method comprises: a) reacting 3-cyano-3,5,5-trimethyl cyclohexanone with excess primary amine as well as removing the water generated from the reaction, so that IPN is substantially converted into imine compounds; b) in the presence of an ammonolysis catalyst, mixing the product of step a) with liquid ammonia, making the imine compound perform ammonolysis reaction to generate 3-cyano-3,5,5-trimethyl cyclohexylimine and the primary amine; and c) in the presence of hydrogen and a hydrogenation catalyst, hydrogenating 3-cyano-3,5,5-trimethyl cyclohexylimine obtained in step b) to obtain 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method of the present invention avoids the generation of 3,5,5-trimethyl cyclohexanol and 3-aminomethyl-3,5,5-trimethyl cyclohexanol as the major by-products in the prior art, thereby improving the yield of 3-aminomethyl-3,5,5-trimethyl cyclohexylamine.

    摘要翻译： 本发明提供3-氨基甲基-3,5,5-三甲基环己胺的制备方法。 该方法包括：a）使3-氰基-3,5,5-三甲基环己酮与过量的伯胺反应，并除去反应产生的水，使得IPN基本上转化为亚胺化合物; b）在氨解催化剂存在下，将步骤a）的产物与液氨混合，使亚胺化合物进行氨解反应，得到3-氰基-3,5,5-三甲基环己基亚胺和伯胺; 和c）在氢气和氢化催化剂的存在下，氢化步骤b）中获得的3-氰基-3,5,5-三甲基环己基亚胺，得到3-氨基甲基-3,5,5-三甲基环己胺。 本发明的方法避免了现有技术中主要副产物3,5,5-三甲基环己醇和3-氨基甲基-3,5,5-三甲基环己醇的产生，从而提高了3-氨基甲基 -3,5,5-三甲基环己胺。

    Continuous process for the hydrogenation of 3-cyano-3,5,5-trimethyl-cyclohexylimine
    5.
    发明授权
    Continuous process for the hydrogenation of 3-cyano-3,5,5-trimethyl-cyclohexylimine 有权
    3-氰基-3,5,5-三甲基 - 环己基亚胺氢化的连续方法

    公开(公告)号：US08884063B2

    公开(公告)日：2014-11-11

    申请号：US12520575

    申请日：2007-12-19

    申请人： Martin Ernst ,  Thomas Hill ,  Piotr Makarczyk ,  Johann-Peter Melder

    发明人： Martin Ernst ,  Thomas Hill ,  Piotr Makarczyk ,  Johann-Peter Melder

    IPC分类号： C07C209/00 ,  C07C209/52 ,  C07C209/48

    CPC分类号： C07C209/48 ,  C07C209/52 ,  C07C2601/14 ,  C07C211/36

    摘要： The present invention relates to a continuous process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine by reacting a feed stream comprising 3-cyano-3,5,5-trimethylcyclohexylimine with hydrogen and ammonia over hydrogenation catalysts, wherein the basicity of the reaction mixture is increased during the reaction by bringing the reaction mixture into contact with a basic compound which is not ammonia and/or a basic catalyst after part of the 3-cyano-3,5,5-trimethylcyclohexylimine has been reacted.

    摘要翻译： 本发明涉及通过在氢化催化剂上使包含3-氰基-3,5,5-三甲基环己基亚胺的进料流与氢和氨反应制备3-氨基甲基-3,5,5-三甲基环己胺的连续方法，其中碱 反应混合物在反应过程中通过在部分3-氰基-3,5,5-三甲基环己基亚胺反应后使反应混合物与不是氨和/或碱性催化剂的碱性化合物接触而增加。

    Asymmetric imine hydrogenation processes
    8.
    发明授权
    Asymmetric imine hydrogenation processes 有权
    不对称亚胺加氢工艺

    公开(公告)号：US07816533B2

    公开(公告)日：2010-10-19

    申请号：US10596489

    申请日：2004-12-15

    申请人： Kamaluddin Abdur-Rashid

    发明人： Kamaluddin Abdur-Rashid

    IPC分类号： C07D211/08

    CPC分类号： C07C209/52 ,  C07C211/27 ,  C07C211/35

    摘要： A process for the catalytic hydrogenation or asymmetric hydrogenation of imines of Formula (I) to the corresponding amines of Formula (II) is provided in which R1 is aryl; R2 is aryl, cyclic, alkyl, alkenyl or alkynyl; and R3 is alkyl. The catalytic system includes a ruthenium complex containing (1) a diamine and (2) a diphosphine or two monodentate phosphines ligands. Such process also relates to the asymmetric hydrogenation of prochiral imines to the chiral amines using chiral ruthenium complexes bearing chiral diphosphines or chiral monodentate phosphines and chiral diamines.

    摘要翻译： 提供了将式（I）的亚胺催化氢化或不对称加氢到相应的式（II）的胺的方法，其中R 1是芳基; R2是芳基，环状，烷基，烯基或炔基; 并且R 3是烷基。 催化体系包括含有（1）二胺和（2）二膦或两个单齿膦配体的钌络合物。 这种方法还涉及使用携带手性二膦或手性单齿膦和手性二胺的手性钌络合物将前手性亚胺与手性胺的不对称氢化反应。

    Asymmetric Imine Hydrogenation Processes
    10.
    发明申请
    Asymmetric Imine Hydrogenation Processes 有权
    不对称亚胺氢化过程

    公开(公告)号：US20070293681A1

    公开(公告)日：2007-12-20

    申请号：US10596489

    申请日：2004-12-15

    申请人： Kamaluddin Abdur-Rashid

    发明人： Kamaluddin Abdur-Rashid

    IPC分类号： C07C209/26 ,  C07D207/06 ,  C07D221/00

    CPC分类号： C07C209/52 ,  C07C211/27 ,  C07C211/35

    摘要： A process for the catalytic hydrogenation or asymmetric hydrogenation of imines of Formula (I) to the corresponding amines of Formula (II) is provided in which R1 is aryl; R2 is aryl, cyclic, alkyl, alkenyl or alkynyl; and R3 is alkyl. The catalytic system includes a ruthenium complex containing (1) a diamine and (2) a diphosphine or two monodentate phosphines ligands. Such process also relates to the asymmetric hydrogenation of prochiral imines to the chiral amines using chiral ruthenium complexes bearing chiral diphosphines or chiral monodentate phosphines and chiral diamines.

    摘要翻译： 提供了式（I）的亚胺与式（II）的相应胺的催化氢化或不对称氢化的方法，其中R 1是芳基; R 2是芳基，环状，烷基，链烯基或炔基; R 3是烷基。 催化体系包括含有（1）二胺和（2）二膦或两个单齿膦配体的钌络合物。 这种方法还涉及使用携带手性二膦或手性单齿膦和手性二胺的手性钌络合物将前手性亚胺与手性胺的不对称氢化反应。