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公开(公告)号：US20150292017A1
公开(公告)日：2015-10-15
申请号：US14749717
申请日：2015-06-25
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun XU , Kenton Duane JUHLIN , Rosemarie OSBORNE , Scott Michael HARTMAN
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/28
摘要： A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.
摘要翻译： 一种用于鉴定美容剂与至少一种与皮肤老化状况相关的基因之间的连接的系统。 该系统包括其上存储有多个实例和皮肤老化基因表达特征的计算机可读介质。 每个实例包括代表由化妆剂与人成纤维细胞或人角质形成细胞之间接触而产生的多个差异表达基因的标识符的有序列表。 计算设备包括用于访问存储在计算机可读介质上的多个实例和皮肤老化基因表达签名的计算机可读指令，将每个实例与皮肤老化基因表达签名进行比较，并将连接性分数分配给每个 基于比较的实例。
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公开(公告)号：US20150292018A1
公开(公告)日：2015-10-15
申请号：US14749779
申请日：2015-06-25
发明人： Robert Lloyd BINDER , Robert Scott YOUNGQUIST , Jun XU , Kenton Duane JUHLIN , Rosemarie OSBORNE , Scott Michael HARTMAN
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B50/00
摘要： A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.
摘要翻译： 一种通过鉴定化妆品和与一种或多种皮肤老化条件相关的基因之间的连接来制备护肤组合物的方法。 该方法包括访问多个实例和至少一个皮肤老化基因表达签名，将至少一个皮肤老化基因表达签名与多个实例进行比较，基于比较为每个实例分配连接性分数并结合化妆品 当与化妆剂相关联的实例的连接性得分具有负相关性时，该药剂成为皮肤护理组合物。
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